Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0066 | 0.1317 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.0104 | 0.3002 | 0.8597 |
Echinococcus granulosus | caspase 2 | 0.0156 | 0.5336 | 0.5336 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0115 | 0.3492 | 1 |
Plasmodium falciparum | metacaspase-like protein | 0.0115 | 0.3492 | 0.5 |
Trichomonas vaginalis | Sentrin-specific protease, putative | 0.0066 | 0.1317 | 0.3772 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0189 | 0.0189 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0115 | 0.3492 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0115 | 0.3492 | 1 |
Trypanosoma brucei | Metacaspase-4 | 0.0115 | 0.3492 | 1 |
Echinococcus granulosus | traf and tnf receptor associated protein | 0.0184 | 0.6611 | 0.6611 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.026 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0115 | 0.3492 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.0024 | 0.0024 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0115 | 0.3492 | 1 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0024 | 0.0037 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.026 | 1 | 1 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0115 | 0.3492 | 1 |
Brugia malayi | Endonuclease/Exonuclease/phosphatase family protein | 0.0184 | 0.6611 | 1 |
Trypanosoma brucei | metacaspase 5, putative | 0.0115 | 0.3492 | 1 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0041 | 0.0189 | 0.0189 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0115 | 0.3492 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0024 | 0.0184 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0115 | 0.3492 | 1 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0156 | 0.5336 | 0.5336 |
Plasmodium vivax | metacaspase 1, putative | 0.0115 | 0.3492 | 0.5 |
Trypanosoma cruzi | metacaspase, putative | 0.0115 | 0.3492 | 1 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0115 | 0.3492 | 0.5482 |
Echinococcus granulosus | sentrin specific protease 8 | 0.0066 | 0.1317 | 0.1317 |
Trypanosoma cruzi | metacaspase, putative | 0.0115 | 0.3492 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0115 | 0.3492 | 1 |
Echinococcus multilocularis | caspase 8 | 0.0115 | 0.3492 | 0.3492 |
Brugia malayi | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0066 | 0.1317 | 0.1992 |
Echinococcus granulosus | caspase | 0.026 | 1 | 1 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0156 | 0.5336 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.0024 | 0.0024 |
Leishmania major | metacaspase, putative | 0.0115 | 0.3492 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0024 | 0.0184 |
Schistosoma mansoni | subfamily C14A unassigned peptidase (C14 family) | 0.0115 | 0.3492 | 0.3492 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.5336 | 0.8224 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0189 | 0.0292 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0189 | 0.0286 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0066 | 0.1317 | 0.3772 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0115 | 0.3492 | 0.5482 |
Trypanosoma cruzi | hypothetical protein | 0.0066 | 0.1317 | 0.3772 |
Plasmodium falciparum | metacaspase 1 | 0.0115 | 0.3492 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0024 | 0.0184 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0115 | 0.3492 | 1 |
Onchocerca volvulus | 0.0041 | 0.0189 | 0.0355 | |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0115 | 0.3492 | 1 |
Trypanosoma brucei | metacaspase | 0.0115 | 0.3492 | 1 |
Loa Loa (eye worm) | Ulp1 protease | 0.0066 | 0.1317 | 0.203 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0115 | 0.3492 | 1 |
Echinococcus multilocularis | traf and tnf receptor associated protein | 0.0184 | 0.6611 | 0.6611 |
Echinococcus multilocularis | caspase 2 | 0.0156 | 0.5336 | 0.5336 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0115 | 0.3492 | 1 |
Brugia malayi | mucosa associated lymphoid tissue lymphoma translocation protein 1 | 0.0115 | 0.3492 | 0.5282 |
Echinococcus multilocularis | caspase | 0.026 | 1 | 1 |
Trypanosoma cruzi | metacaspase, putative | 0.0115 | 0.3492 | 1 |
Schistosoma mansoni | family C48 unassigned peptidase (C48 family) | 0.0066 | 0.1317 | 0.1317 |
Schistosoma mansoni | hypothetical protein | 0.0104 | 0.3002 | 0.3002 |
Echinococcus granulosus | caspase 8 | 0.0115 | 0.3492 | 0.3492 |
Brugia malayi | Cell death protein 3 precursor | 0.0156 | 0.5336 | 0.807 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0024 | 0.0184 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0115 | 0.3492 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0115 | 0.3492 | 1 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.026 | 1 | 1 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0041 | 0.0189 | 0.0189 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0115 | 0.3492 | 0.5482 |
Echinococcus multilocularis | caspase 3 | 0.0145 | 0.4854 | 0.4854 |
Loa Loa (eye worm) | endonuclease/Exonuclease/phosphatase | 0.0181 | 0.6488 | 1 |
Toxoplasma gondii | endonuclease/exonuclease/phosphatase family protein | 0.0179 | 0.637 | 1 |
Trypanosoma brucei | metacaspase MCA3 | 0.0115 | 0.3492 | 1 |
Trypanosoma cruzi | metacaspase, putative | 0.0115 | 0.3492 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0115 | 0.3492 | 1 |
Echinococcus granulosus | caspase 3 | 0.0145 | 0.4854 | 0.4854 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0066 | 0.1317 | 0.3772 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0115 | 0.3492 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.3492 | 0.5383 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0024 | 0.0024 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0066 | 0.1317 | 0.3772 |
Echinococcus multilocularis | sentrin specific protease 8 | 0.0066 | 0.1317 | 0.1317 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.0024 | 0.0024 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0115 | 0.3492 | 1 |
Trypanosoma brucei | metacaspase MCA2 | 0.0115 | 0.3492 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.