Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1585 | 0.1547 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0311 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1585 | 0.1547 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.1585 | 0.1547 |
Onchocerca volvulus | 0.0267 | 0.8437 | 1 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1585 | 0.1547 |
Schistosoma mansoni | glutaminase | 0.0308 | 0.9916 | 0.9915 |
Loa Loa (eye worm) | TK/EPH protein kinase | 0.0152 | 0.4304 | 0.4279 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0311 | 1 | 1 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.015 | 0.422 | 0.4194 |
Echinococcus granulosus | ephrin type A receptor 4 A | 0.0133 | 0.3609 | 0.3609 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.1585 | 0.1547 |
Echinococcus multilocularis | 0.0046 | 0.0487 | 0.0444 | |
Leishmania major | 0.0311 | 1 | 0.5 | |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.1585 | 0.1585 |
Trichomonas vaginalis | glutaminase, putative | 0.0308 | 0.9916 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0049 | 0.0587 | 0.0545 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.015 | 0.422 | 0.4194 |
Schistosoma mansoni | tyrosine kinase | 0.015 | 0.422 | 0.4194 |
Schistosoma mansoni | tyrosine kinase | 0.0049 | 0.0587 | 0.0545 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0081 | 0.175 | 0.1713 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.015 | 0.422 | 0.4194 |
Loa Loa (eye worm) | glutaminase 2 | 0.0308 | 0.9916 | 0.9915 |
Brugia malayi | RNA binding protein | 0.0076 | 0.1585 | 0.1547 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0053 | 0.0746 | 0.0705 |
Echinococcus granulosus | insulin receptor | 0.0049 | 0.0587 | 0.0587 |
Brugia malayi | ephrin receptor 1 precursor | 0.0058 | 0.0906 | 0.0865 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0311 | 1 | 1 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0311 | 1 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.015 | 0.422 | 0.422 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0053 | 0.0746 | 0.0746 |
Schistosoma mansoni | tyrosine kinase | 0.0079 | 0.1672 | 0.1635 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1585 | 0.1547 |
Plasmodium vivax | SET domain protein, putative | 0.0034 | 0.0045 | 0.5 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0081 | 0.175 | 0.175 |
Schistosoma mansoni | tyrosine kinase | 0.0081 | 0.175 | 0.1713 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.3067 | 0.3036 |
Loa Loa (eye worm) | glutaminase | 0.0308 | 0.9916 | 0.9915 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.1585 | 0.1547 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.1585 | 0.1547 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0081 | 0.175 | 0.175 |
Brugia malayi | glutaminase DH11.1 | 0.0308 | 0.9916 | 0.9915 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0311 | 1 | 1 |
Onchocerca volvulus | 0.0118 | 0.3067 | 0.3601 | |
Schistosoma mansoni | tyrosine kinase | 0.0081 | 0.175 | 0.1713 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0311 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0079 | 0.1672 | 0.1635 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0049 | 0.0587 | 0.0545 |
Echinococcus multilocularis | ephrin type A receptor 4 A | 0.0133 | 0.3609 | 0.3581 |
Schistosoma mansoni | tyrosine kinase | 0.0079 | 0.1672 | 0.1635 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0311 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1585 | 0.1547 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0235 | 0.7271 | 0.7259 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0988 | 0.0948 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.1585 | 0.1547 |
Brugia malayi | Pre-SET motif family protein | 0.0235 | 0.7271 | 0.7259 |
Mycobacterium ulcerans | glutaminase | 0.0308 | 0.9916 | 0.5 |
Echinococcus multilocularis | insulin receptor | 0.0049 | 0.0587 | 0.0545 |
Toxoplasma gondii | sedoheptulose-1,7-bisphosphatase | 0.0115 | 0.2987 | 0.2955 |
Toxoplasma gondii | fructose-bisphospatase I | 0.0115 | 0.2987 | 0.2955 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0034 | 0.0045 | 0.0045 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.1585 | 0.1547 |
Schistosoma mansoni | tyrosine kinase | 0.0049 | 0.0587 | 0.0545 |
Schistosoma mansoni | ephrin receptor | 0.012 | 0.3144 | 0.3113 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0311 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.