Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0103 | 0.0524 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0073 | 0.0328 | 0.0328 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0053 | 0.0199 | 0.0199 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0067 | 0.0289 | 0.2776 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0289 | 0.0289 |
Plasmodium falciparum | macrophage migration inhibitory factor | 0.1583 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0084 | 0.04 | 0.04 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1583 | 1 | 1 |
Echinococcus granulosus | twitchin | 0.0067 | 0.0292 | 0.2876 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0103 | 0.0524 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0289 | 0.0289 |
Giardia lamblia | Macrophage migration inhibitory factor | 0.1583 | 1 | 1 |
Entamoeba histolytica | macrophage migration inhibitory factor-like protein | 0.1583 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0067 | 0.0289 | 0.0289 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0289 | 0.0289 |
Echinococcus multilocularis | Immunoglobulin | 0.0067 | 0.0289 | 0.2776 |
Toxoplasma gondii | macrophage migration inhibitory factor, putative | 0.1583 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0095 | 0.0473 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0289 | 0.0289 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0041 | 0.0124 | 0.0124 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0067 | 0.0289 | 0.0289 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.1583 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0053 | 0.0199 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.007 | 0.0312 | 0.3498 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0289 | 0.0289 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0524 | 0.0524 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0289 | 0.0289 |
Loa Loa (eye worm) | macrophage migration inhibitory factor | 0.1583 | 1 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.0067 | 0.0289 | 0.2776 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0067 | 0.0289 | 0.472 |
Onchocerca volvulus | 0.0053 | 0.0199 | 0.5 | |
Echinococcus granulosus | roundabout 2 | 0.0067 | 0.0289 | 0.2776 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0675 | 0.4187 | 0.4187 |
Echinococcus granulosus | Immunoglobulin | 0.0067 | 0.0289 | 0.2776 |
Schistosoma mansoni | nephrin | 0.0067 | 0.0289 | 0.472 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.007 | 0.0312 | 0.3498 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0289 | 0.0289 |
Echinococcus granulosus | neuroglian | 0.0067 | 0.0289 | 0.2776 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0073 | 0.0328 | 0.0328 |
Echinococcus multilocularis | Immunoglobulin | 0.0067 | 0.0289 | 0.2776 |
Schistosoma mansoni | cell adhesion molecule | 0.0067 | 0.0289 | 0.472 |
Echinococcus multilocularis | neuroglian | 0.0067 | 0.0289 | 0.2776 |
Trichomonas vaginalis | macrophage migration inhibitory factor, mif, putative | 0.1583 | 1 | 1 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0084 | 0.04 | 0.04 |
Loa Loa (eye worm) | glutamate receptor | 0.0033 | 0.0074 | 0.0074 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0053 | 0.0199 | 0.0199 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0067 | 0.0289 | 0.2776 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0067 | 0.0289 | 0.0289 |
Echinococcus granulosus | defective proboscis extension response | 0.0067 | 0.0289 | 0.2776 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0289 | 0.0289 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.0053 | 0.0199 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.007 | 0.0312 | 0.5392 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0067 | 0.0289 | 0.472 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0076 | 0.0349 | 0.0349 |
Schistosoma mansoni | glycogen synthase kinase 3-related (gsk3) (cmgc group III) | 0.0053 | 0.0199 | 0.2134 |
Schistosoma mansoni | vesicular amine transporter | 0.0067 | 0.0289 | 0.472 |
Brugia malayi | intracellular kinase | 0.0053 | 0.0199 | 0.0199 |
Plasmodium vivax | macrophage migration inhibitory factor, putative | 0.1583 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0289 | 0.0289 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0675 | 0.4187 | 0.4187 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.1583 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.