Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | neuroendocrine convertase 2 | 0.01 | 0.1952 | 0.1795 |
Echinococcus multilocularis | sodium coupled monocarboxylate transporter 1 | 0.0042 | 0.033 | 0.0141 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.0042 | 0.033 | 0.0141 |
Echinococcus multilocularis | 0.0128 | 0.2752 | 0.261 | |
Brugia malayi | endoprotease bli-4 precursor | 0.0159 | 0.362 | 0.3402 |
Loa Loa (eye worm) | endoprotease bli-4 | 0.0159 | 0.362 | 0.3496 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.0384 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0187 | 0.443 | 0.443 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.0384 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0187 | 0.443 | 0.443 |
Schistosoma mansoni | furin-1 (S08 family) | 0.0069 | 0.1084 | 0.1084 |
Schistosoma mansoni | inositol transporter | 0.0042 | 0.033 | 0.033 |
Echinococcus granulosus | solute carrier family 5 | 0.0042 | 0.033 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 1 | 1 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0037 | 0.0192 | 0.1032 |
Echinococcus multilocularis | solute carrier family 5 | 0.0042 | 0.033 | 0.0141 |
Echinococcus granulosus | proprotein convertase subtilisin:kexin type 5 | 0.0096 | 0.186 | 0.1701 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0037 | 0.0192 | 0.1032 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0096 | 0.186 | 1 |
Echinococcus granulosus | sodium coupled monocarboxylate transporter 1 | 0.0042 | 0.033 | 0.0141 |
Schistosoma mansoni | high-affinity choline transporter | 0.0384 | 1 | 1 |
Onchocerca volvulus | 0.0042 | 0.033 | 0.5 | |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0037 | 0.0192 | 0.1032 |
Echinococcus multilocularis | proprotein convertase subtilisin:kexin type 5 | 0.0096 | 0.186 | 0.1701 |
Echinococcus granulosus | furin | 0.0159 | 0.362 | 0.3496 |
Echinococcus granulosus | sodium:glucose cotransporter | 0.0042 | 0.033 | 0.0141 |
Echinococcus multilocularis | neuroendocrine convertase 2 | 0.01 | 0.1952 | 0.1795 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0037 | 0.0192 | 0.1032 |
Schistosoma mansoni | sodium/solute symporter | 0.0042 | 0.033 | 0.033 |
Echinococcus multilocularis | geminin | 0.0187 | 0.443 | 0.4321 |
Schistosoma mansoni | subfamily S8B non-peptidase homologue (S08 family) | 0.0037 | 0.0192 | 0.0192 |
Brugia malayi | proprotein convertase 2 | 0.01 | 0.1952 | 0.1677 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0037 | 0.0192 | 0.1032 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.362 | 0.3496 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.0042 | 0.033 | 0.0141 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.0042 | 0.033 | 0.0141 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0096 | 0.186 | 1 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.0042 | 0.033 | 0.0141 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0037 | 0.0192 | 0.1032 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.0042 | 0.033 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.033 | 0.0141 |
Schistosoma mansoni | subfamily S8B unassigned peptidase (S08 family) | 0.0159 | 0.362 | 0.362 |
Giardia lamblia | High cysteine membrane protein Group 2 | 0.0059 | 0.08 | 1 |
Brugia malayi | celfurPC protein | 0.0128 | 0.2752 | 0.2504 |
Schistosoma mansoni | inositol transporter | 0.0042 | 0.033 | 0.033 |
Brugia malayi | neuroendocrine convertase 1 precursor | 0.01 | 0.1952 | 0.1677 |
Echinococcus granulosus | geminin | 0.0187 | 0.443 | 0.4321 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0892 | 0.0714 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AbsAC1 (functional) | = 16.7 uM | PubChem BioAssay. Small Molecule Inhibitors of FGF22-Mediated Excitatory Synaptogenesis & Epilepsy Measured in Biochemical System Using RT-PCR - 7012-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.