Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hypothetical protein, conserved | 0.0015 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0029 | 0.0039 | 0.0039 |
Trypanosoma brucei | btb/poz domain containing protein, putative | 0.0015 | 0 | 0.5 |
Trypanosoma cruzi | btb/poz domain containing protein, putative | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0352 | 0.0999 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily D | 0.0029 | 0.0039 | 0.0039 |
Echinococcus multilocularis | potassium voltage gated channel subfamily D | 0.0029 | 0.0039 | 0.0039 |
Echinococcus multilocularis | solute carrier family 28 | 0.3387 | 1 | 1 |
Plasmodium vivax | K+ channel tetramerisation domain containing protein | 0.0015 | 0 | 0.5 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0029 | 0.0039 | 0.0039 |
Echinococcus granulosus | potassium voltage gated channel subfamily C | 0.0029 | 0.0039 | 0.0039 |
Trypanosoma brucei | btb/poz domain containing protein, putative | 0.0015 | 0 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0029 | 0.0039 | 0.0039 |
Brugia malayi | Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog | 0.0029 | 0.0039 | 0.0394 |
Trypanosoma brucei | potassium voltage-gated channel, putative | 0.0015 | 0 | 0.5 |
Onchocerca volvulus | 0.0015 | 0 | 0.5 | |
Echinococcus granulosus | potassium voltage gated channel subfamily A | 0.0352 | 0.0999 | 0.0999 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0015 | 0 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily A | 0.0337 | 0.0953 | 0.0953 |
Plasmodium vivax | kelch protein K13, putative | 0.0015 | 0 | 0.5 |
Trypanosoma brucei | BTB/POZ domain/Regulator of chromosome condensation (RCC1) repeat, putative | 0.0015 | 0 | 0.5 |
Trypanosoma cruzi | btb/poz domain containing protein, putative | 0.0015 | 0 | 0.5 |
Trypanosoma cruzi | potassium voltage-gated channel, putative | 0.0015 | 0 | 0.5 |
Trypanosoma cruzi | btb/poz domain containing protein, putative | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0029 | 0.0039 | 0.0394 |
Echinococcus granulosus | Potassium voltage gated channel protein Shaw | 0.0029 | 0.0039 | 0.0039 |
Echinococcus multilocularis | shaker cognate | 0.0029 | 0.0039 | 0.0039 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0352 | 0.0999 | 1 |
Toxoplasma gondii | kelch repeat and K+ channel tetramerisation domain containing protein | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0029 | 0.0039 | 0.0394 |
Loa Loa (eye worm) | voltage-gated potassium channel | 0.0029 | 0.0039 | 0.0394 |
Trypanosoma brucei | btb/poz domain containing protein, putative | 0.0015 | 0 | 0.5 |
Trypanosoma cruzi | potassium voltage-gated channel | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | vesicular amine transporter | 0.0029 | 0.0039 | 0.0394 |
Leishmania major | hypothetical protein, conserved | 0.0015 | 0 | 0.5 |
Echinococcus multilocularis | sodium:nucleoside cotransporter 2 | 0.2209 | 0.6506 | 0.6506 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0029 | 0.0039 | 0.0394 |
Trypanosoma cruzi | btb/poz domain containing protein, putative | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | voltage gated potassium channel | 0.0029 | 0.0039 | 0.0039 |
Toxoplasma gondii | K+ channel tetramerisation domain-containing protein | 0.0015 | 0 | 0.5 |
Trypanosoma cruzi | btb/poz domain containing protein, putative | 0.0015 | 0 | 0.5 |
Trypanosoma brucei | btb/poz domain containing protein, putative | 0.0015 | 0 | 0.5 |
Echinococcus multilocularis | concentrative Na+ nucleoside cotransporter | 0.3387 | 1 | 1 |
Echinococcus multilocularis | transfer RNA-Gly | 0.0029 | 0.0039 | 0.0039 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0029 | 0.0039 | 0.0394 |
Trypanosoma cruzi | btb/poz domain containing protein, putative | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | Na+ dependent nucleoside transporter | 0.3387 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0352 | 0.0999 | 1 |
Leishmania major | potassium voltage-gated channel, putative | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | concentrative Na nucleoside cotransporter | 0.3387 | 1 | 1 |
Onchocerca volvulus | 0.0015 | 0 | 0.5 | |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0352 | 0.0999 | 0.0999 |
Echinococcus granulosus | potassium voltage gated channel subfamily D | 0.0029 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0039 | 0.0394 |
Echinococcus granulosus | shaker cognate | 0.0029 | 0.0039 | 0.0039 |
Echinococcus multilocularis | potassium voltage gated channel subfamily C | 0.0029 | 0.0039 | 0.0039 |
Brugia malayi | Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit | 0.0352 | 0.0999 | 1 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0029 | 0.0039 | 0.0039 |
Onchocerca volvulus | 0.0015 | 0 | 0.5 | |
Onchocerca volvulus | 0.0015 | 0 | 0.5 | |
Schistosoma mansoni | voltage-gated potassium channel | 0.0029 | 0.0039 | 0.0394 |
Leishmania major | hypothetical protein, conserved | 0.0015 | 0 | 0.5 |
Onchocerca volvulus | 0.0015 | 0 | 0.5 | |
Trypanosoma brucei | potassium voltage-gated channel, putative | 0.0015 | 0 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit | 0.0029 | 0.0039 | 0.0394 |
Echinococcus granulosus | potassium voltage gated channel subfamily D | 0.0029 | 0.0039 | 0.0039 |
Plasmodium falciparum | kelch protein K13 | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0352 | 0.0999 | 0.0999 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0029 | 0.0039 | 0.0039 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0029 | 0.0039 | 0.0394 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AbsAC1 (functional) | = 18.36 uM | PubChem BioAssay. Small Molecule Inhibitors of FGF22-Mediated Excitatory Synaptogenesis & Epilepsy Measured in Biochemical System Using RT-PCR - 7012-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.