Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.2422 | 0.5 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.2422 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.2422 | 0.5 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.2422 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.2422 | 0.5 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.2422 | 0.5 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.2422 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.2422 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.2422 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2422 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2422 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2422 | 0.5 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.2422 | 0.5 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.2422 | 0.5 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.2422 | 0.5 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.2422 | 0.5 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2422 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2422 | 0.5 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.2422 | 0.5 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.2422 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | < 25 % | Inhibition of full length PI3Kalpha (unknown origin) assessed as reduction in PIP3 formation at 100 uM using PIP2 as substrate after 45 mins by fluorescence polarization assay relative to control | LITERATURE. | 28129991 |
Inhibition (binding) | < 25 % | Inhibition of wild type PI3K p110alpha/p85alpha niSH2 (unknown origin) expressed in baculovirus infected sf9 cells assessed as reduction in PIP3 formation at 100 uM using PIP2 as substrate after 45 mins by fluorescence polarization assay relative to control | LITERATURE. | 28129991 |
Log A (functional) | = 0.94 | Activity expressed by taste potency (taste intensity relative to sucrose on a mole/mole basis) | ChEMBL. | 7365747 |
Log A (functional) | = 0.94 | Activity expressed by taste potency (taste intensity relative to sucrose on a mole/mole basis) | ChEMBL. | 7365747 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.