Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | paired box 8 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Onchocerca volvulus | Get druggable targets OG5_139945 | All targets in OG5_139945 | |
Brugia malayi | Pax transcription factor protein 2 | Get druggable targets OG5_139945 | All targets in OG5_139945 |
Loa Loa (eye worm) | pax transcription factor protein 2 | Get druggable targets OG5_139945 | All targets in OG5_139945 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.1005 | 0.1434 | 0.3428 |
Trichomonas vaginalis | conserved hypothetical protein | 0.2279 | 0.3993 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.2374 | 0.4184 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.1005 | 0.1434 | 0.3428 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2374 | 0.4184 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.2374 | 0.4184 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.2374 | 0.4184 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.2374 | 0.4184 | 0.5 |
Onchocerca volvulus | 0.0291 | 0 | 0.5 | |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.2374 | 0.4184 | 0.321 |
Mycobacterium ulcerans | carbonic anhydrase | 0.5271 | 1 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.2374 | 0.4184 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1005 | 0.1434 | 0.3428 |
Leishmania major | carbonic anhydrase family protein, putative | 0.5271 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1005 | 0.1434 | 0.3428 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1005 | 0.1434 | 0.3428 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1005 | 0.1434 | 0.3428 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.5271 | 1 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.1005 | 0.1434 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.2374 | 0.4184 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.5271 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1005 | 0.1434 | 0.3428 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.2374 | 0.4184 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.1005 | 0.1434 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2374 | 0.4184 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1005 | 0.1434 | 0.3428 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1005 | 0.1434 | 0.3428 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.2374 | 0.4184 | 0.321 |
Trichomonas vaginalis | conserved hypothetical protein | 0.2279 | 0.3993 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.2992 | 0.5423 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (functional) | = 8.98 uM | PubChem BioAssay. HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.