Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0369 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0144 | 0.3809 | 0.3809 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0144 | 0.3809 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0369 | 1 | 1 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0144 | 0.3809 | 1 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0144 | 0.3809 | 1 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0144 | 0.3809 | 0.3809 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0144 | 0.3809 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0144 | 0.3809 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0369 | 1 | 1 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0369 | 1 | 0.5 |
Onchocerca volvulus | Mitochondrial Rho GTPase homolog | 0.0006 | 0 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0144 | 0.3809 | 1 |
Echinococcus granulosus | leucine rich repeat serine:threonine protein | 0.0135 | 0.3546 | 0.931 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0144 | 0.3809 | 1 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0369 | 1 | 1 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0369 | 1 | 1 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0369 | 1 | 1 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0369 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0144 | 0.3809 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0144 | 0.3809 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0369 | 1 | 0.5 |
Leishmania major | dihydroorotate dehydrogenase | 0.0369 | 1 | 1 |
Loa Loa (eye worm) | TKL/LRRK protein kinase | 0.0134 | 0.3521 | 1 |
Echinococcus multilocularis | leucine rich repeat serine:threonine protein | 0.0134 | 0.3521 | 0.9245 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0369 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0144 | 0.3809 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0369 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0134 | 0.3521 | 0.3521 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0144 | 0.3809 | 1 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0369 | 1 | 1 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0369 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.