Detailed view for OVOC5737

Basic information

TDR Targets ID: 986938
Onchocerca volvulus, Mitochondrial Rho GTPase homolog
Source Database / ID:  Wormbase Parasite  

pI: 8.803 | Length (AA): 59 | MW (Da): 7082 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00071  
PF08355  
PF08356  
PF08477  
PF13405  

Gene Ontology

Mouse over links to read term descriptions.
GO:0047497   mitochondrion transport along microtubule  
GO:0031307   integral to mitochondrial outer membrane  
GO:0019725   cellular homeostasis  
GO:0006184   GTP catabolic process  
GO:0016020   membrane  
GO:0005741   mitochondrial outer membrane  
GO:0005622   intracellular  
GO:0005509   calcium ion binding  
GO:0003924   GTPase activity  
GO:0005525   GTP binding  
GO:0015031   protein transport  
GO:0007264   small GTPase mediated signal transduction  
GO:0007165   signal transduction  

Metabolic Pathways

Mitophagy - animal (KEGG)
Apoptosis - fly (KEGG)

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
15 201 1wf3 (A) 3 187 19.00 0 1 0.557319 -0.81
15 176 1r2q (A) 16 174 27.00 0.00012 1 0.660824 -0.96
20 184 2ocb (A) 8 173 24.00 0.0019 1 0.724563 -1.45
21 137 3q72 (A) 93 206 35.00 0.35 0.89 0.0467341 1.26
197 599 4c0k (A) 206 609 46.00 0 1 1.23555 -0.7
199 599 5ksz (A) 182 581 47.00 0 1 1.27209 -0.97
315 383 3ox6 (E) 16 87 20.00 0 0.89 0.443905 -1.4

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128473)

Species Accession Gene Product
Arabidopsis thaliana AT3G05310   MIRO-related GTP-ase 3
Arabidopsis thaliana AT5G27540   MIRO-related GTP-ase 1
Arabidopsis thaliana AT3G63150   MIRO-related GTP-ase 2
Brugia malayi Bm1_35005   EF hand family protein
Candida albicans CaO19.13437   has ATP/GTP and calcium binding site domains
Candida albicans CaO19.6016   has ATP/GTP and calcium binding site domains
Caenorhabditis elegans CELE_K08F11.5   Protein MIRO-1
Dictyostelium discoideum DDB_G0267830   Ras-related GTPase
Drosophila melanogaster Dmel_CG5410   Mitochondrial Rho
Echinococcus granulosus EgrG_000177500   mitochondrial Rho GTPase 1
Echinococcus multilocularis EmuJ_000177500   mitochondrial Rho GTPase 1
Homo sapiens ENSG00000140983   ras homolog family member T2
Homo sapiens ENSG00000126858   ras homolog family member T1
Loa Loa (eye worm) LOAG_10162   EF hand family protein
Loa Loa (eye worm) LOAG_13940   hypothetical protein
Mus musculus ENSMUSG00000017686   ras homolog gene family, member T1
Mus musculus ENSMUSG00000025733   ras homolog gene family, member T2
Oryza sativa 4334534   Os03g0810600
Oryza sativa 4327503   Os01g0843300
Onchocerca volvulus OVOC5737   Mitochondrial Rho GTPase homolog
Saccharomyces cerevisiae YAL048C   ERMES complex Ca(2+)-binding regulatory GTPase GEM1
Schistosoma japonicum Sjp_0204750   ko:K07870 Ras homolog gene family, member T1, putative
Schistosoma mansoni Smp_149440   rac-GTP binding protein
Schmidtea mediterranea mk4.001886.06   Mitochondrial Rho GTPase
Schmidtea mediterranea mk4.002206.02   Mitochondrial Rho GTPase
Schmidtea mediterranea mk4.001886.07   Mitochondrial Rho GTPase
Schmidtea mediterranea mk4.006482.00   Mitochondrial Rho GTPase
Schmidtea mediterranea mk4.001886.05   Mitochondrial Rho GTPase

Essentiality

OVOC5737 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_K08F11.5 Caenorhabditis elegans larval lethal wormbase
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

No enough druggable targets predicted through repurposing network model to make a plot

Putative Drugs List

Compound Raw Global Species
0.0016 0.2966 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC5737 (Onchocerca volvulus), Mitochondrial Rho GTPase homolog
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