Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | synuclein, alpha (non A4 component of amyloid precursor) | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein, conserved | 0.1466 | 0.1702 | 1 |
Chlamydia trachomatis | hypothetical protein | 0.1466 | 0.1702 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.1466 | 0.1702 | 1 |
Schistosoma mansoni | biotin-protein ligase | 0.1466 | 0.1702 | 1 |
Giardia lamblia | Hypothetical protein | 0.1075 | 0.0755 | 0.5 |
Plasmodium falciparum | biotin--acetyl-CoA-carboxylase, putative | 0.1075 | 0.0755 | 0.5 |
Echinococcus granulosus | N terminal of biotin protein ligase | 0.1466 | 0.1702 | 1 |
Trypanosoma brucei | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.1075 | 0.0755 | 0.5 |
Mycobacterium ulcerans | bifunctional protein BirA | 0.4581 | 0.9245 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.1466 | 0.1702 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.1466 | 0.1702 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.1466 | 0.1702 | 1 |
Treponema pallidum | biotin--acetyl-CoA-carboxylase ligase | 0.4893 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.1466 | 0.1702 | 1 |
Wolbachia endosymbiont of Brugia malayi | biotin-(acetyl-CoA carboxylase) ligase | 0.1075 | 0.0755 | 0.5 |
Leishmania major | biotin/lipoate protein ligase-like protein | 0.1075 | 0.0755 | 0.5 |
Trypanosoma cruzi | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.1075 | 0.0755 | 0.5 |
Mycobacterium leprae | POSSIBLE BIFUNCTIONAL PROTEIN BirA: BIOTIN OPERON REPRESSOR + BIOTIN--[ACETYL-COA-CARBOXYLASE] SYNTHETASE (BIOTIN--PROTEIN LIGAS | 0.0763 | 0 | 0.5 |
Loa Loa (eye worm) | biotin protein ligase 1 | 0.1075 | 0.0755 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.1466 | 0.1702 | 1 |
Brugia malayi | biotin--acetyl-CoA-carboxylase ligase family protein | 0.1075 | 0.0755 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.1466 | 0.1702 | 1 |
Echinococcus multilocularis | N terminal of biotin protein ligase | 0.1466 | 0.1702 | 1 |
Trypanosoma cruzi | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.1075 | 0.0755 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.1466 | 0.1702 | 1 |
Plasmodium vivax | biotin--[acetyl-CoA-carboxylase] synthetase, putative | 0.1075 | 0.0755 | 0.5 |
Plasmodium falciparum | biotin protein ligase, putative | 0.1075 | 0.0755 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.6234 uM | PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.