Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | histone arginine methyltransferase PRMT4/CARM1 | 0.0582 | 1 | 0.5 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0389 | 0.5353 | 0.5353 |
Echinococcus multilocularis | histone arginine methyltransferase CARMER | 0.0582 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.0766 | 0.0766 |
Entamoeba histolytica | arginine N-methyltransferase protein, putative | 0.0167 | 0 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0389 | 0.5353 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0389 | 0.5353 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0167 | 0 | 0.5 |
Loa Loa (eye worm) | Carm1-pending protein | 0.0582 | 1 | 1 |
Echinococcus granulosus | histone arginine methyltransferase CARMER | 0.0582 | 1 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0389 | 0.5353 | 1 |
Schistosoma mansoni | protein arginine n-methyltransferase | 0.0582 | 1 | 0.5 |
Onchocerca volvulus | 0.0479 | 0.7533 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0389 | 0.5353 | 0.5353 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 125.8925 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.