Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | carbonic anhydrase-like protein | 0.092 | 0.597 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.092 | 0.597 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.092 | 0.597 | 0.597 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0416 | 0.227 | 0.227 |
Echinococcus granulosus | carbonic anhydrase | 0.0416 | 0.227 | 0.3803 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.092 | 0.597 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.092 | 0.597 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.1469 | 1 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.092 | 0.597 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1469 | 1 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0416 | 0.227 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1469 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0416 | 0.227 | 0.227 |
Schistosoma mansoni | carbonic anhydrase | 0.0416 | 0.227 | 0.227 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0146 | 0.0283 | 0.0475 |
Loa Loa (eye worm) | hypothetical protein | 0.0416 | 0.227 | 0.3803 |
Loa Loa (eye worm) | hypothetical protein | 0.0416 | 0.227 | 0.3803 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0416 | 0.227 | 0.227 |
Leishmania major | carbonic anhydrase family protein, putative | 0.1469 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0416 | 0.227 | 0.3803 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0416 | 0.227 | 0.3803 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0416 | 0.227 | 0.3803 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.092 | 0.597 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0416 | 0.227 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.0283 | 0.0475 |
Brugia malayi | Muscleblind-like protein | 0.0146 | 0.0283 | 0.0475 |
Schistosoma mansoni | hypothetical protein | 0.0416 | 0.227 | 0.227 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0635 | 0.3879 | 0.7269 |
Echinococcus granulosus | muscleblind protein | 0.0146 | 0.0283 | 0.0475 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.092 | 0.597 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0416 | 0.227 | 0.3803 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.092 | 0.597 | 0.597 |
Echinococcus multilocularis | carbonic anhydrase | 0.0416 | 0.227 | 0.3803 |
Echinococcus multilocularis | muscleblind protein | 0.0146 | 0.0283 | 0.0475 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0635 | 0.3879 | 0.5 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0416 | 0.227 | 0.3803 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0635 | 0.3879 | 0.5 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0107 | 0 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.0416 | 0.227 | 0.3803 |
Echinococcus multilocularis | carbonic anhydrase II | 0.092 | 0.597 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0416 | 0.227 | 0.3803 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.0283 | 0.0475 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0416 | 0.227 | 0.3803 |
Loa Loa (eye worm) | hypothetical protein | 0.0416 | 0.227 | 0.3803 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.092 | 0.597 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0416 | 0.227 | 0.3803 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0834 | 0.5336 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.092 | 0.597 | 0.597 |
Echinococcus multilocularis | carbonic anhydrase | 0.0416 | 0.227 | 0.3803 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AbsAC1 (functional) | > 38 uM | PubChem BioAssay. Small Molecule Inhibitors of FGF22-Mediated Excitatory Synaptogenesis & Epilepsy Measured in Biochemical System Using RT-PCR - 7012-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.