Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | leucine-rich repeat kinase 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | leucine rich repeat serine:threonine protein | Get druggable targets OG5_131478 | All targets in OG5_131478 |
Echinococcus granulosus | leucine rich repeat serine:threonine protein | Get druggable targets OG5_131478 | All targets in OG5_131478 |
Brugia malayi | Protein kinase domain containing protein | Get druggable targets OG5_131478 | All targets in OG5_131478 |
Loa Loa (eye worm) | TKL/LRRK protein kinase | Get druggable targets OG5_131478 | All targets in OG5_131478 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0036 | 0.0444 | 0.5 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0444 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0164 | 0.9532 | 0.9532 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0444 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0444 | 0.5 |
Loa Loa (eye worm) | TKL/LRRK protein kinase | 0.007 | 0.2859 | 0.2999 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0444 | 0.5 |
Echinococcus granulosus | leucine rich repeat serine:threonine protein | 0.0071 | 0.2893 | 0.2893 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0036 | 0.0444 | 0.5 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0036 | 0.0444 | 0.0466 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0036 | 0.0444 | 0.0444 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0444 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0141 | 0.7906 | 0.7906 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0444 | 0.5 |
Trypanosoma brucei | glucosidase, putative | 0.0036 | 0.0444 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0164 | 0.9532 | 0.9532 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0444 | 0.5 |
Onchocerca volvulus | 0.0095 | 0.4608 | 1 | |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0444 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 1 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0444 | 0.5 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0036 | 0.0444 | 0.5 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0036 | 0.0444 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 1 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0036 | 0.0444 | 0.0466 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0444 | 0.5 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0036 | 0.0444 | 0.0444 |
Echinococcus multilocularis | geminin | 0.0171 | 1 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0164 | 0.9532 | 0.9532 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0164 | 0.9532 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0164 | 0.9532 | 1 |
Echinococcus multilocularis | leucine rich repeat serine:threonine protein | 0.007 | 0.2859 | 0.2859 |
Schistosoma mansoni | alpha-glucosidase | 0.0141 | 0.7906 | 0.7906 |
Brugia malayi | Protein kinase domain containing protein | 0.007 | 0.2859 | 0.2999 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0036 | 0.0444 | 0.5 |
Schistosoma mansoni | alpha glucosidase | 0.0036 | 0.0444 | 0.0444 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.