Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | aldehyde dehydrogenase | 0.0065 | 0.014 | 0.014 |
Schistosoma mansoni | hypothetical protein | 0.0293 | 0.2537 | 0.2537 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0065 | 0.014 | 0.0062 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0293 | 0.2537 | 0.2479 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0293 | 0.2537 | 0.2537 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0065 | 0.014 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.1003 | 1 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0063 | 0.0118 | 0.0118 |
Brugia malayi | hypothetical protein | 0.0293 | 0.2537 | 0.2537 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.014 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0252 | 0.2105 | 0.2091 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0065 | 0.014 | 0.5 |
Schistosoma mansoni | inhibitor of apoptosis (iap) domain family member | 0.1003 | 1 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0063 | 0.0118 | 0.0118 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.2537 | 0.2524 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0065 | 0.014 | 0.0062 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0063 | 0.0118 | 0.0041 |
Onchocerca volvulus | 0.1003 | 1 | 1 | |
Onchocerca volvulus | 0.0293 | 0.2537 | 0.2537 | |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0063 | 0.0118 | 0.0041 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.014 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1003 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.0018 | 0.0018 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0252 | 0.2105 | 0.2043 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0065 | 0.014 | 0.5 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0293 | 0.2537 | 0.2479 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0734 | 0.7179 | 0.7179 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0063 | 0.0118 | 0.0041 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.1003 | 1 | 1 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0734 | 0.7179 | 0.7157 |
Loa Loa (eye worm) | hypothetical protein | 0.1003 | 1 | 1 |
Echinococcus granulosus | inhibitor of apoptosis protein | 0.1003 | 1 | 1 |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.1003 | 1 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0059 | 0.0078 | 0.0078 |
Schistosoma mansoni | inhibitor of apoptosis protein | 0.1003 | 1 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0063 | 0.0118 | 0.0118 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0127 | 0.0796 | 0.0779 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0063 | 0.0118 | 0.0118 |
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.1003 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0127 | 0.0796 | 0.0779 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0063 | 0.0118 | 0.01 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0734 | 0.7179 | 0.7157 |
Brugia malayi | Cell death protein 3 precursor | 0.0293 | 0.2537 | 0.2537 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0293 | 0.2537 | 0.2537 |
Onchocerca volvulus | Deterin homolog | 0.1003 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0127 | 0.0796 | 0.0796 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0063 | 0.0118 | 0.0041 |
Echinococcus granulosus | caspase 2 | 0.0293 | 0.2537 | 0.2479 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.0018 | 0.0018 |
Echinococcus multilocularis | caspase 2 | 0.0293 | 0.2537 | 0.2479 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0252 | 0.2105 | 0.2043 |
Echinococcus multilocularis | inhibitor of apoptosis protein | 0.1003 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0065 | 0.014 | 0.014 |
Brugia malayi | jmjC domain containing protein | 0.0063 | 0.0118 | 0.0118 |
Brugia malayi | hypothetical protein | 0.0252 | 0.2105 | 0.2105 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.014 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.2537 | 0.2524 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Acceptor activity (binding) | = 50.9 | Electron acceptor activity on bovine milk xanthine oxidase using xanthine as reducing substrate | ChEMBL. | 15163191 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.