Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Helix-loop-helix DNA-binding domain containing protein | 0.0087 | 0.0281 | 0.0277 |
Trichomonas vaginalis | conserved hypothetical protein | 0.2298 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0177 | 0.0677 | 0.0673 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.0026 | 0.0024 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0086 | 0.0278 | 0.0274 |
Loa Loa (eye worm) | macrophage migration inhibitory factor | 0.2298 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0096 | 0.0321 | 0.0317 |
Entamoeba histolytica | macrophage migration inhibitory factor-like protein | 0.2298 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0082 | 0.0258 | 0.0283 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0037 | 0.006 | 0.066 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0037 | 0.006 | 0.0056 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.098 | 0.4208 | 0.4205 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0218 | 0.0857 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0029 | 0.0026 | 0.0299 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0029 | 0.0025 | 0.0021 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0082 | 0.0258 | 0.2166 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0075 | 0.0071 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0037 | 0.006 | 0.0063 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0082 | 0.0258 | 0.5 |
Loa Loa (eye worm) | helix-loop-helix DNA-binding domain-containing protein | 0.0087 | 0.0279 | 0.0275 |
Trypanosoma brucei | polo-like protein kinase | 0.0082 | 0.0258 | 0.5 |
Trichomonas vaginalis | set domain proteins, putative | 0.0191 | 0.0737 | 0.0654 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0148 | 0.0551 | 0.6425 |
Plasmodium vivax | macrophage migration inhibitory factor, putative | 0.2298 | 1 | 1 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.2298 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0037 | 0.006 | 0.0702 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0082 | 0.0258 | 0.0171 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0037 | 0.006 | 0.0063 |
Schistosoma mansoni | hypothetical protein | 0.0027 | 0.0019 | 0.0017 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0082 | 0.0258 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0096 | 0.0321 | 0.0317 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0037 | 0.006 | 0.066 |
Onchocerca volvulus | 0.0291 | 0.1176 | 1 | |
Echinococcus multilocularis | geminin | 0.0137 | 0.0499 | 0.5798 |
Giardia lamblia | Macrophage migration inhibitory factor | 0.2298 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0082 | 0.0258 | 0.0171 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.004 | 0.0075 | 0.0071 |
Echinococcus multilocularis | transcription factor eb | 0.0087 | 0.0281 | 0.3243 |
Loa Loa (eye worm) | glutamate receptor | 0.007 | 0.0205 | 0.0201 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0027 | 0.0019 | 0.0015 |
Onchocerca volvulus | 0.0191 | 0.0737 | 0.6259 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.2062 | 0.8961 | 1 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0082 | 0.0258 | 0.0254 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0086 | 0.0278 | 0.0306 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0168 | 0.0636 | 0.0632 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0279 | 0.0275 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0201 | 0.0784 | 0.0871 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0026 | 0.0022 |
Toxoplasma gondii | macrophage migration inhibitory factor, putative | 0.2298 | 1 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0024 | 0.0004 | 0.0045 |
Echinococcus granulosus | geminin | 0.0137 | 0.0499 | 0.5817 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0025 | 0.0021 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0177 | 0.0677 | 0.0673 |
Brugia malayi | Pax transcription factor protein 2 | 0.0291 | 0.1176 | 0.1172 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.098 | 0.4208 | 0.4205 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0161 | 0.0604 | 0.06 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0291 | 0.1176 | 0.1172 |
Plasmodium falciparum | macrophage migration inhibitory factor | 0.2298 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0137 | 0.0499 | 0.0552 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0045 | 0.0098 | 0.0094 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0082 | 0.0258 | 0.0254 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0098 | 0.0094 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0082 | 0.0258 | 0.2976 |
Brugia malayi | Protein kinase domain containing protein | 0.2062 | 0.8961 | 0.8961 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0082 | 0.0258 | 0.0233 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.2062 | 0.8961 | 0.8961 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0019 | 0.0015 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0148 | 0.0551 | 0.061 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0029 | 0.0026 | 0.0254 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0082 | 0.0258 | 0.0171 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0096 | 0.0321 | 0.0317 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0082 | 0.0258 | 0.3008 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0037 | 0.006 | 0.0702 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.0025 | 0.0023 |
Schistosoma mansoni | hypothetical protein | 0.0137 | 0.0499 | 0.0552 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0037 | 0.006 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.0857 | 0.0853 |
Echinococcus multilocularis | GPCR, family 3, C terminal | 0.0029 | 0.0025 | 0.0242 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0029 | 0.0026 | 0.0024 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0045 | 0.0098 | 0.0094 |
Echinococcus granulosus | GPCR family 3 C terminal | 0.0029 | 0.0025 | 0.0286 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.2298 | 1 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0168 | 0.0636 | 0.0632 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0218 | 0.0857 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0082 | 0.0258 | 0.0171 |
Trichomonas vaginalis | macrophage migration inhibitory factor, mif, putative | 0.2298 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0082 | 0.0258 | 0.0171 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0045 | 0.0098 | 0.0094 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0029 | 0.0025 | 0.0176 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.004 | 0.0075 | 0.0071 |
Schistosoma mansoni | kinase | 0.0044 | 0.0093 | 0.01 |
Echinococcus granulosus | transcription factor eb | 0.0087 | 0.0281 | 0.3274 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0082 | 0.0258 | 0.0171 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0037 | 0.006 | 0.0056 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0148 | 0.0551 | 0.6408 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0029 | 0.0025 | 0.0176 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.004 | 0.0075 | 0.0071 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0082 | 0.0258 | 0.0171 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AbsAC1 (functional) | > 38 uM | PubChem BioAssay. Small Molecule Inhibitors of FGF22-Mediated Excitatory Synaptogenesis & Epilepsy Measured in Biochemical System Using RT-PCR - 7012-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.