Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | isocitrate dehydrogenase 1 (NADP+), soluble | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ecdysone induced protein 78C | 0.0242 | 0.0496 | 0.0496 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0242 | 0.0496 | 0.1703 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0242 | 0.0496 | 0.1703 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0242 | 0.0496 | 0.1703 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0242 | 0.0496 | 0.0572 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0242 | 0.0496 | 0.1703 |
Loa Loa (eye worm) | hypothetical protein | 0.0562 | 0.2912 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.0496 | 0.1703 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.1325 | 0.8673 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.0496 | 0.1703 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.0496 | 0.1703 |
Schistosoma mansoni | thyroid hormone receptor | 0.0242 | 0.0496 | 0.0496 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0242 | 0.0496 | 0.1703 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0562 | 0.2912 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0242 | 0.0496 | 0.0496 |
Brugia malayi | nuclear hormone receptor | 0.0242 | 0.0496 | 0.1703 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0242 | 0.0496 | 0.0496 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0242 | 0.0496 | 0.1703 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0242 | 0.0496 | 0.1703 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0242 | 0.0496 | 0.0572 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0242 | 0.0496 | 0.0496 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0242 | 0.0496 | 0.1703 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0242 | 0.0496 | 0.1703 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0242 | 0.0496 | 0.0496 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0242 | 0.0496 | 0.0572 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.0496 | 0.1703 |
Schistosoma mansoni | thyroid hormone receptor | 0.0242 | 0.0496 | 0.0496 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0242 | 0.0496 | 0.1703 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0242 | 0.0496 | 0.0496 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0242 | 0.0496 | 0.0572 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0242 | 0.0496 | 0.0572 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0242 | 0.0496 | 0.1703 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0242 | 0.0496 | 0.1703 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0242 | 0.0496 | 0.1703 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.0496 | 0.1703 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0242 | 0.0496 | 0.0496 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0242 | 0.0496 | 0.0496 |
Echinococcus granulosus | FTZ F1 alpha | 0.0242 | 0.0496 | 0.0496 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0242 | 0.0496 | 0.1703 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0242 | 0.0496 | 0.0572 |
Brugia malayi | ecdysteroid receptor | 0.0562 | 0.2912 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0242 | 0.0496 | 0.0572 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0242 | 0.0496 | 0.0496 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0242 | 0.0496 | 0.1703 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.0496 | 0.1703 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0242 | 0.0496 | 0.1703 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0242 | 0.0496 | 0.1703 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0242 | 0.0496 | 0.0496 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0242 | 0.0496 | 0.1703 |
Brugia malayi | nuclear receptor NHR-88 | 0.0242 | 0.0496 | 0.1703 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0242 | 0.0496 | 0.1703 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.0496 | 0.1703 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0242 | 0.0496 | 0.1703 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0242 | 0.0496 | 0.1703 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0242 | 0.0496 | 0.0496 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0242 | 0.0496 | 0.0496 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0242 | 0.0496 | 0.1703 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0242 | 0.0496 | 0.0496 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0242 | 0.0496 | 0.0572 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0242 | 0.0496 | 0.0496 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.1501 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0242 | 0.0496 | 0.0572 |
Brugia malayi | steroid hormone receptor | 0.0242 | 0.0496 | 0.1703 |
Schistosoma mansoni | coup transcription factor | 0.0242 | 0.0496 | 0.0496 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0242 | 0.0496 | 0.1703 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0242 | 0.0496 | 0.1703 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0242 | 0.0496 | 0.0496 |
Schistosoma mansoni | nuclear hormone receptor | 0.0242 | 0.0496 | 0.0496 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 12.9953 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.