Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0058 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0108 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0058 | 0.5371 |
Echinococcus multilocularis | solute carrier family 28 | 0.3843 | 1 | 1 |
Echinococcus granulosus | concentrative Na nucleoside cotransporter | 0.3843 | 1 | 1 |
Echinococcus granulosus | Na+ dependent nucleoside transporter | 0.3843 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0108 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0108 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0108 | 1 |
Echinococcus multilocularis | sodium:nucleoside cotransporter 2 | 0.2506 | 0.6505 | 0.6505 |
Echinococcus multilocularis | concentrative Na+ nucleoside cotransporter | 0.3843 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0058 | 0.5371 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 23.1093 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.