Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | wd40 repeat | 0.0078 | 0.0554 | 0.0554 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0554 | 0.0554 |
Onchocerca volvulus | 0.0635 | 1 | 0.5 | |
Trichomonas vaginalis | retinoblastoma binding protein, putative | 0.0078 | 0.0554 | 0.0554 |
Plasmodium falciparum | SPRY domain, putative | 0.0045 | 0 | 0.5 |
Brugia malayi | Hypothetical WD-repeat protein F21H12.1 in chromosome II | 0.0078 | 0.0554 | 0.0554 |
Loa Loa (eye worm) | WD40 repeat protein | 0.0635 | 1 | 1 |
Schistosoma mansoni | retinoblastoma binding protein | 0.0078 | 0.0554 | 0.0554 |
Trichomonas vaginalis | WD repeat domain, putative | 0.0635 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0635 | 1 | 1 |
Echinococcus multilocularis | wd40 repeat | 0.0078 | 0.0554 | 0.0554 |
Echinococcus granulosus | protein will die slowly | 0.0635 | 1 | 1 |
Echinococcus multilocularis | protein will die slowly | 0.0635 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0.0554 | 0.0554 |
Plasmodium vivax | hypothetical protein, conserved | 0.0045 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.