Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0255 | 0.0471 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0255 | 0.0471 | 0.1764 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0255 | 0.0471 | 0.5 |
Schistosoma mansoni | amine oxidase | 0.0255 | 0.0471 | 0.5 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0255 | 0.0471 | 0.1764 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.0471 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.0471 | 0.5 |
Giardia lamblia | Telomerase catalytic subunit | 0.1267 | 0.267 | 0.5 |
Brugia malayi | Telomerase reverse transcriptase | 0.3371 | 0.7246 | 1 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.3371 | 0.7245 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.1267 | 0.267 | 1 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0255 | 0.0471 | 0.5 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.1267 | 0.267 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0255 | 0.0471 | 0.1764 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.3627 | 0.7801 | 1 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.1267 | 0.267 | 1 |
Leishmania major | telomerase reverse transcriptase, putative | 0.1267 | 0.267 | 1 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0255 | 0.0471 | 0.5 |
Mycobacterium ulcerans | oxidoreductase | 0.0255 | 0.0471 | 0.0604 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.3627 | 0.7801 | 1 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0255 | 0.0471 | 0.1764 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.0471 | 0.5 |
Treponema pallidum | DNA polymerase I (polA) | 0.0055 | 0.0034 | 0.5 |
Mycobacterium ulcerans | monoamine oxidase | 0.0255 | 0.0471 | 0.0604 |
Echinococcus multilocularis | 0.0255 | 0.0471 | 0.5 | |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0255 | 0.0471 | 0.1764 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0255 | 0.0471 | 0.0604 |
Wolbachia endosymbiont of Brugia malayi | DNA polymerase I | 0.0055 | 0.0034 | 0.5 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0255 | 0.0471 | 0.5 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0255 | 0.0471 | 0.1764 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.1267 | 0.267 | 1 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0255 | 0.0471 | 0.1764 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0255 | 0.0471 | 0.1764 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0255 | 0.0471 | 1 |
Leishmania major | UDP-galactopyranose mutase | 0.0255 | 0.0471 | 0.1764 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.0471 | 0.5 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0255 | 0.0471 | 0.065 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.1267 | 0.267 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0255 | 0.0471 | 0.065 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.0471 | 0.5 |
Mycobacterium ulcerans | DNA polymerase I | 0.0055 | 0.0034 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.0471 | 0.5 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.1267 | 0.267 | 1 |
Mycobacterium tuberculosis | Probable DNA polymerase I PolA | 0.0055 | 0.0034 | 0.0047 |
Mycobacterium ulcerans | dehydrogenase | 0.0255 | 0.0471 | 0.0604 |
Schistosoma mansoni | amine oxidase | 0.0255 | 0.0471 | 0.5 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0255 | 0.0471 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0255 | 0.0471 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0255 | 0.0471 | 0.1764 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.