Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0377 | 0.8867 | 0.8867 |
Echinococcus granulosus | histone arginine methyltransferase CARMER | 0.0415 | 1 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0377 | 0.8867 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0377 | 0.8867 | 1 |
Toxoplasma gondii | histone arginine methyltransferase PRMT4/CARM1 | 0.0415 | 1 | 0.5 |
Loa Loa (eye worm) | Carm1-pending protein | 0.0415 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0085 | 0 | 0.5 |
Onchocerca volvulus | 0.0361 | 0.8385 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0377 | 0.8867 | 0.8867 |
Entamoeba histolytica | arginine N-methyltransferase protein, putative | 0.0085 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.328 | 0.328 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0377 | 0.8867 | 0.5 |
Schistosoma mansoni | protein arginine n-methyltransferase | 0.0415 | 1 | 0.5 |
Echinococcus multilocularis | histone arginine methyltransferase CARMER | 0.0415 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 29.0929 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.