Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Trypanosoma cruzi | trypanothione reductase, putative | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | trypanothione reductase, putative | 492 aa | 548 aa | 21.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0202 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0202 | 1 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0026 | 0.0383 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0076 | 0.3107 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0026 | 0.0383 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0202 | 1 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0076 | 0.3107 | 0.2832 |
Brugia malayi | Thioredoxin reductase | 0.0076 | 0.3107 | 0.3107 |
Plasmodium vivax | glutathione reductase, putative | 0.0076 | 0.3107 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0202 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0202 | 1 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0026 | 0.0383 | 0.0383 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0202 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0202 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0026 | 0.0383 | 0.5 |
Treponema pallidum | NADH oxidase | 0.0026 | 0.0383 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0202 | 1 | 1 |
Brugia malayi | glutathione reductase | 0.0076 | 0.3107 | 0.3107 |
Plasmodium falciparum | thioredoxin reductase | 0.0076 | 0.3107 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0076 | 0.3107 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0076 | 0.3107 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0202 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0202 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0202 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0202 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0202 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0026 | 0.0383 | 0.5 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0026 | 0.0383 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0026 | 0.0383 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0076 | 0.3107 | 0.2832 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0202 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0202 | 1 | 1 |
Leishmania major | trypanothione reductase | 0.0076 | 0.3107 | 0.2832 |
Toxoplasma gondii | thioredoxin reductase | 0.0076 | 0.3107 | 0.2832 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0202 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0202 | 1 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0202 | 1 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0026 | 0.0383 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0076 | 0.3107 | 0.2832 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0076 | 0.3107 | 0.2832 |
Trypanosoma brucei | protein kinase, putative | 0.0202 | 1 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0202 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.4 uM | Inhibitory activity against T. cruzi trypanothione reductase | ChEMBL. | 10956223 |
IC50 (binding) | = 5.4 uM | Inhibitory activity against T. cruzi trypanothione reductase | ChEMBL. | 10956223 |
Ki (binding) | = 0.77 uM | Inhibitory activity against T. cruzi trypanothione reductase | ChEMBL. | 10956223 |
Ki (binding) | = 0.77 uM | Inhibitory activity against T. cruzi trypanothione reductase | ChEMBL. | 10956223 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.