Detailed information for compound 1756683

Basic information

Technical information
  • TDR Targets ID: 1756683
  • Name: 1-(2-methoxyphenyl)-3-(1-pyridin-2-ylethylide neamino)thiourea
  • MW: 300.379 | Formula: C15H16N4OS
  • H donors: 2 H acceptors: 1 LogP: 2.62 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1NC(=S)N/N=C(/c1ccccn1)\C
  • InChi: 1S/C15H16N4OS/c1-11(12-7-5-6-10-16-12)18-19-15(21)17-13-8-3-4-9-14(13)20-2/h3-10H,1-2H3,(H2,17,19,21)/b18-11+
  • InChiKey: PHYCOZLZEUMCBU-WOJGMQOQSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(2-methoxyphenyl)-3-[1-(2-pyridyl)ethylideneamino]thiourea
  • NCI60_023789
  • NSC668297
  • (1E)-1-(2-Pyridinyl)ethanone N-(2-methoxyphenyl)thiosemicarbazone
  • 2-acetylpyridine 4-[2-Methoxyphenyl]-3-thiosemicarbazone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0036 0.0037
Entamoeba histolytica hexokinase 2 0.0096 0.0168 1
Trypanosoma brucei hexokinase 0.0096 0.0168 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Onchocerca volvulus 0.0048 0.0036 0.2169
Schistosoma mansoni histamine h1 receptor 0.0048 0.0036 0.0127
Onchocerca volvulus 0.0048 0.0036 0.2169
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.0036 0.0037
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0048 0.0036 0.0036
Onchocerca volvulus 0.0048 0.0036 0.2169
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0301 0.2637
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0036 0.0037
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0048 0.0036 0.0127
Onchocerca volvulus 0.0048 0.0036 0.2169
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0036 0.0037
Echinococcus granulosus sex peptide receptor 0.0048 0.0036 0.0036
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.0036 0.0037
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Brugia malayi hypothetical protein 0.0048 0.0036 0.0055
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0048 0.0036 0.0055
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.1074 0.2867 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0048 0.0036 0.0036
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.006 0.0061
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.0262 0.8342
Onchocerca volvulus 0.0048 0.0036 0.2169
Onchocerca volvulus 0.0048 0.0036 0.2169
Schistosoma mansoni neuropeptide receptor 0.0048 0.0036 0.0127
Brugia malayi Dopamine receptor protein 1 0.0448 0.114 0.1708
Echinococcus granulosus neuropeptide Y receptor 0.0048 0.0036 0.0036
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0048 0.0036 0.0037
Schistosoma mansoni hypothetical protein 0.0048 0.0036 0.0127
Schistosoma mansoni hypothetical protein 0.0048 0.0036 0.0127
Brugia malayi Serotonin receptor 0.0048 0.0036 0.0055
Schistosoma mansoni neuropeptide receptor 0.0048 0.0036 0.0127
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0048 0.0036 0.0127
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0048 0.0036 0.032
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0048 0.0036 0.032
Onchocerca volvulus 0.0048 0.0036 0.2169
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0048 0.0036 0.0037
Schistosoma mansoni opsin-like receptor 0.0048 0.0036 0.0127
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0048 0.0036 0.0037
Onchocerca volvulus 0.0048 0.0036 0.2169
Brugia malayi G protein-coupled receptor F59B2.13 0.0048 0.0036 0.0055
Brugia malayi Melatonin receptor type 1A 0.0048 0.0036 0.0055
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Plasmodium falciparum glutathione reductase 0.0057 0.006 0.0211
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.0036 0.0037
Brugia malayi hypothetical protein 0.0043 0.0023 0.0034
Brugia malayi neuropeptide F receptor 0.0048 0.0036 0.0055
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0036 0.0127
Brugia malayi putative neuropeptide receptor NPR1 0.0048 0.0036 0.0055
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Schistosoma mansoni hypothetical protein 0.0205 0.0468 0.1631
Brugia malayi Thioredoxin reductase 0.0057 0.006 0.009
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0036 0.0127
Echinococcus granulosus alpha 1A adrenergic receptor 0.0048 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Loa Loa (eye worm) hypothetical protein 0.006 0.0069 0.0609
Brugia malayi jmjC domain containing protein 0.0115 0.0221 0.0331
Loa Loa (eye worm) hexokinase 0.006 0.0069 0.0608
Onchocerca volvulus 0.006 0.0069 0.4122
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.002 0.0071
Brugia malayi Dopamine receptor protein 2 0.0048 0.0036 0.0055
Loa Loa (eye worm) neuropeptide F receptor 0.0048 0.0036 0.032
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.0262 0.8342
Echinococcus granulosus g protein coupled receptor 0.0048 0.0036 0.0036
Entamoeba histolytica hexokinase 1 0.0096 0.0168 1
Loa Loa (eye worm) hypothetical protein 0.0448 0.114 1
Brugia malayi larval opioid receptor 0.0048 0.0036 0.0055
Echinococcus multilocularis serotonin receptor 0.0048 0.0036 0.0037
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0036 0.0037
Toxoplasma gondii thioredoxin reductase 0.0057 0.006 0.0211
Brugia malayi putative neuropeptide receptor 0.0048 0.0036 0.0055
Loa Loa (eye worm) hexokinase 0.0096 0.0168 0.1476
Echinococcus granulosus G protein coupled receptor 139 0.0048 0.0036 0.0036
Schistosoma mansoni biogenic amine (5HT) receptor 0.0048 0.0036 0.0127
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0048 0.0036 0.0055
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Schistosoma mansoni adenoreceptor 0.0048 0.0036 0.0127
Echinococcus multilocularis g protein coupled receptor 0.0048 0.0036 0.0037
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0048 0.0036 0.032
Schistosoma mansoni hypothetical protein 0.0048 0.0036 0.0127
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.0036 0.0036
Echinococcus granulosus neuropeptide receptor 0.0048 0.0036 0.0036
Echinococcus granulosus hexokinase 0.0096 0.0168 0.0168
Plasmodium falciparum thioredoxin reductase 0.0057 0.006 0.0211
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.006 0.006
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0036 0.0036
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0036 0.0037
Brugia malayi MH2 domain containing protein 0.0144 0.0301 0.045
Brugia malayi sulfakinin receptor protein 0.0048 0.0036 0.0055
Echinococcus multilocularis hexokinase 0.0096 0.0168 0.0171
Schistosoma mansoni hypothetical protein 0.0048 0.0036 0.0127
Treponema pallidum hexokinase (hxk) 0.0096 0.0168 0.5
Echinococcus granulosus hexokinase 0.0096 0.0168 0.0168
Onchocerca volvulus 0.0048 0.0036 0.2169
Brugia malayi GnHR receptor homolog 0.0048 0.0036 0.0055
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.006 0.0211
Echinococcus multilocularis neuropeptides capa receptor 0.0048 0.0036 0.0037
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0048 0.0036 0.2169
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0048 0.0036 0.0127
Brugia malayi Tachykinin-like peptides receptor 99D 0.0048 0.0036 0.0055
Echinococcus granulosus fmrfamide receptor 0.0048 0.0036 0.0036
Loa Loa (eye worm) hexokinase 0.0096 0.0168 0.1476
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.0036 0.0127
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0048 0.0036 0.0037
Echinococcus multilocularis g-protein coupled receptor 0.0048 0.0036 0.0037
Brugia malayi hypothetical protein 0.0048 0.0036 0.0055
Schistosoma mansoni amine GPCR 0.0048 0.0036 0.0127
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0048 0.0036 0.0055
Schistosoma mansoni amine GPCR 0.0048 0.0036 0.0127
Onchocerca volvulus 0.0048 0.0036 0.2169
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0408 0.1028 0.3584
Loa Loa (eye worm) glutathione reductase 0.0057 0.006 0.053
Onchocerca volvulus 0.0096 0.0168 1
Echinococcus multilocularis orexin receptor type 2 0.0048 0.0036 0.0037
Onchocerca volvulus 0.0048 0.0036 0.2169
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.0302 1
Brugia malayi hypothetical protein 0.0048 0.0036 0.0055
Brugia malayi neuropeptide F receptor 0.0048 0.0036 0.0055
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0103 0.0907
Echinococcus granulosus biogenic amine 5HT receptor 0.0048 0.0036 0.0036
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.0302 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0048 0.0036 0.0036
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0036 0.0127
Echinococcus granulosus neuropeptide Y receptor 0.0048 0.0036 0.0036
Echinococcus multilocularis geminin 0.0205 0.0468 0.0474
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Trypanosoma brucei hexokinase, putative 0.0096 0.0168 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.0302 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0048 0.0036 0.0037
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0048 0.0036 0.0037
Schistosoma mansoni alpha-1 adrenergic receptor 0.0048 0.0036 0.0127
Leishmania major hexokinase, putative 0.0096 0.0168 1
Brugia malayi hypothetical protein 0.0048 0.0036 0.0055
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Echinococcus granulosus neuropeptides capa receptor 0.0048 0.0036 0.0036
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0408 0.1028 0.3584
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0036 0.0036
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0023 0.0079
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.0221 0.0221
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0048 0.0036 0.0036
Echinococcus granulosus g protein coupled receptor 0.0048 0.0036 0.0036
Brugia malayi G-protein coupled receptor 0.0048 0.0036 0.0055
Loa Loa (eye worm) neuropeptide F receptor 0.0048 0.0036 0.032
Onchocerca volvulus 0.0048 0.0036 0.2169
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0048 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0043 0.0023 0.0079
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.1074 0.2867 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0036 0.0127
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.002 0.002
Schistosoma mansoni myosin xvIII 0.0048 0.0036 0.0127
Giardia lamblia Dipeptidyl-peptidase I precursor 0.1074 0.2867 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0036 0.0036
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.002 0.0071
Echinococcus multilocularis neuropeptide receptor 0.0048 0.0036 0.0037
Toxoplasma gondii cathepsin CPC1 0.1074 0.2867 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0036 0.0127
Onchocerca volvulus 0.0096 0.0168 1
Onchocerca volvulus 0.0048 0.0036 0.2169
Echinococcus granulosus neuropeptide FF receptor 2 0.0048 0.0036 0.0036
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.0262 0.8342
Echinococcus granulosus neuropeptides capa receptor 0.0048 0.0036 0.0036
Echinococcus multilocularis hexokinase type 2 0.0096 0.0168 0.0171
Schistosoma mansoni neuropeptide receptor 0.0048 0.0036 0.0127
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0667 0.1743 0.5
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.0262 0.8342
Brugia malayi Hexokinase family protein 0.0096 0.0168 0.0252
Schistosoma mansoni growth hormone secretagogue receptor 0.0048 0.0036 0.0127
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Echinococcus multilocularis serotonin receptor 0.0048 0.0036 0.0037
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0038 0.0038
Echinococcus granulosus neuropeptide receptor 0.0048 0.0036 0.0036
Trypanosoma cruzi hexokinase, putative 0.0096 0.0168 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Echinococcus multilocularis neuropeptide Y receptor 0.0048 0.0036 0.0037
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0038 0.0039
Echinococcus granulosus orexin receptor type 2 0.0048 0.0036 0.0036
Schistosoma mansoni neuropeptide f receptor 76f 0.0048 0.0036 0.0127
Schistosoma mansoni opsin-like receptor 0.0048 0.0036 0.0127
Echinococcus multilocularis dro:myosuppressin receptor 0.0048 0.0036 0.0037
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0036 0.0127
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Brugia malayi hexokinase 0.0096 0.0168 0.0252
Brugia malayi hypothetical protein 0.0048 0.0036 0.0055
Echinococcus granulosus allatostatin A receptor 0.0048 0.0036 0.0036
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.1074 0.2867 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Mycobacterium tuberculosis Probable reductase 0.013 0.0262 0.8342
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0048 0.0036 0.0036
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.002 0.0021
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0048 0.0036 0.032
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0036 0.0036
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0048 0.0036 0.0127
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0036 0.0036
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.0262 0.8342
Echinococcus multilocularis hexokinase 0.0096 0.0168 0.0171
Brugia malayi hypothetical protein 0.0048 0.0036 0.0055
Echinococcus granulosus hexokinase type 2 0.0096 0.0168 0.0168
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0048 0.0036 0.0055
Loa Loa (eye worm) TYRA-2 protein 0.0048 0.0036 0.032
Echinococcus multilocularis neuropeptide Y receptor 0.0048 0.0036 0.0037
Echinococcus granulosus g protein coupled receptor 0.0048 0.0036 0.0036
Giardia lamblia Encystation-specific protease 0.0408 0.1028 0.3584
Onchocerca volvulus 0.0096 0.0168 1
Leishmania major hexokinase, putative 0.0096 0.0168 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0048 0.0036 0.0037
Brugia malayi AKH receptor 0.0048 0.0036 0.0055
Toxoplasma gondii cathepsin CPC2 0.0408 0.1028 0.3584
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Echinococcus granulosus g-protein coupled receptor 0.0048 0.0036 0.0036
Trypanosoma cruzi hexokinase, putative 0.0096 0.0168 1
Echinococcus granulosus serotonin receptor 0.0048 0.0036 0.0036
Onchocerca volvulus 0.0048 0.0036 0.2169
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.0036 0.0127
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Onchocerca volvulus Neuropeptide F receptor homolog 0.0048 0.0036 0.2169
Brugia malayi Serotonin receptor 0.2455 0.6679 1
Echinococcus multilocularis hexokinase 0.0096 0.0168 0.0171
Echinococcus multilocularis G-protein coupled receptor, putative 0.0048 0.0036 0.0037
Echinococcus multilocularis neuropeptides capa receptor 0.0048 0.0036 0.0037
Onchocerca volvulus Hexokinase homolog 0.006 0.0069 0.4122
Brugia malayi hypothetical protein 0.0048 0.0036 0.0055
Schistosoma mansoni jumonji domain containing protein 0.0092 0.0156 0.0543
Brugia malayi ORL1-like opioid receptor 0.0048 0.0036 0.0055
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0036 0.0036
Schistosoma mansoni biogenic amine receptor 0.0048 0.0036 0.0127
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0408 0.1028 0.3584
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0036 0.0127
Echinococcus multilocularis fmrfamide receptor 0.0048 0.0036 0.0037
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0023 0.0023
Echinococcus multilocularis fmrfamide receptor 0.0048 0.0036 0.0037
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Loa Loa (eye worm) G-protein coupled receptor 0.0048 0.0036 0.032
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0048 0.0036 0.0127
Schistosoma mansoni amine GPCR 0.0048 0.0036 0.0127
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.1074 0.2867 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.002 0.0179
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.006 0.053
Echinococcus multilocularis g protein coupled receptor 0.0048 0.0036 0.0037
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Echinococcus multilocularis allatostatin A receptor 0.0048 0.0036 0.0037
Echinococcus multilocularis g protein coupled receptor 0.0048 0.0036 0.0037
Brugia malayi glutathione reductase 0.0057 0.006 0.009
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.1074 0.2867 1
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0408 0.1028 0.3584
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Echinococcus multilocularis neuropeptide receptor A26 0.0048 0.0036 0.0037
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.0221 0.0224
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Echinococcus granulosus geminin 0.0205 0.0468 0.0468
Echinococcus granulosus 7TM GPCR rhodopsin 0.0048 0.0036 0.0036
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0048 0.0036 0.0037
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0048 0.0036 0.0127
Echinococcus granulosus peptide allatostatin:somatostatin 0.0048 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0036 0.0127
Echinococcus granulosus tachykinin peptides receptor 99D 0.0048 0.0036 0.0036
Echinococcus granulosus hexokinase 0.0096 0.0168 0.0168
Schistosoma mansoni biogenic amine receptor 0.0048 0.0036 0.0127
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0036 0.0037
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0048 0.0036 0.0127
Schistosoma mansoni amine GPCR 0.0048 0.0036 0.0127
Onchocerca volvulus 0.0048 0.0036 0.2169
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0048 0.0036 0.0037
Onchocerca volvulus 0.0048 0.0036 0.2169
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Echinococcus granulosus neuropeptide receptor A26 0.0048 0.0036 0.0036
Echinococcus granulosus neuropeptide s receptor 0.0048 0.0036 0.0036
Schistosoma mansoni neuropeptide F-like receptor 0.0048 0.0036 0.0127
Brugia malayi RE15519p 0.0048 0.0036 0.0055
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0048 0.0036 0.0127
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0048 0.0036 0.0127
Echinococcus multilocularis somatostatin receptor 0.0048 0.0036 0.0037
Brugia malayi hypothetical protein 0.0048 0.0036 0.0055
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0048 0.0036 0.0037
Schistosoma mansoni hypothetical protein 0.0205 0.0468 0.1631
Trypanosoma brucei hexokinase 0.0096 0.0168 1
Toxoplasma gondii hexokinase 0.0096 0.0168 0.0587
Echinococcus multilocularis sex peptide receptor 0.0048 0.0036 0.0037
Plasmodium falciparum hexokinase 0.0096 0.0168 0.0587
Loa Loa (eye worm) hypothetical protein 0.0066 0.0084 0.0736
Brugia malayi follicle stimulating hormone receptor 0.0048 0.0036 0.0055
Schistosoma mansoni amine GPCR 0.0048 0.0036 0.0127
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0036 0.0037
Schistosoma mansoni biogenic amine receptor 0.0048 0.0036 0.0127
Brugia malayi hypothetical protein 0.0048 0.0036 0.0055
Loa Loa (eye worm) melatonin receptor type 1A 0.0048 0.0036 0.032
Echinococcus granulosus dro:myosuppressin receptor 0.0048 0.0036 0.0036
Echinococcus multilocularis G protein coupled receptor 139 0.0048 0.0036 0.0037
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Brugia malayi jmjC domain containing protein 0.0043 0.002 0.0031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0036 0.0127
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.0036 0.0127
Echinococcus multilocularis neuropeptide FF receptor 2 0.0048 0.0036 0.0037
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0301 0.2637
Plasmodium vivax glutathione reductase, putative 0.0057 0.006 0.0211
Echinococcus granulosus 7tm_1 domain containing protein 0.0048 0.0036 0.0036
Schistosoma mansoni opsin-like receptor 0.0048 0.0036 0.0127
Toxoplasma gondii preprocathepsin c precursor, putative 0.1074 0.2867 1
Plasmodium vivax hexokinase, putative 0.0096 0.0168 0.0587
Brugia malayi Dopamine receptor 0.0048 0.0036 0.0055
Brugia malayi G protein-coupled receptor 0.0048 0.0036 0.0055
Loa Loa (eye worm) hexokinase type II 0.0096 0.0168 0.1476
Schistosoma mansoni neuropeptide receptor 0.0048 0.0036 0.0127
Echinococcus multilocularis conserved hypothetical protein 0.361 0.9866 1
Schistosoma mansoni neuropeptide F-like receptor 0.0048 0.0036 0.0127
Onchocerca volvulus 0.0048 0.0036 0.2169
Schistosoma mansoni hexokinase 0.0096 0.0168 0.0587
Loa Loa (eye worm) G-protein coupled receptor 0.0048 0.0036 0.032
Echinococcus multilocularis neuropeptide s receptor 0.0048 0.0036 0.0037
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0048 0.0036 0.032
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Brugia malayi Hexokinase family protein 0.006 0.0069 0.0104
Schistosoma mansoni biogenic amine (5HT) receptor 0.0048 0.0036 0.0127
Brugia malayi G-protein coupled receptor 0.0048 0.0036 0.0055
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0036 0.0037
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0048 0.0036 0.0037
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0048 0.0036 0.0127
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0048 0.0036 0.0036
Echinococcus multilocularis neuropeptide receptor 0.0048 0.0036 0.0037
Brugia malayi hypothetical protein 0.0048 0.0036 0.0055
Echinococcus granulosus somatostatin receptor 0.0048 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0048 0.0036 0.0055
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.0302 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.032

Activities

Activity type Activity value Assay description Source Reference
MST (functional) = 0.1 day Antimalarial activity against Plasmodium berghei KBG 173 infected in ICR/HA Swiss mouse assessed as increase in mean survival time at 40 mg/kg, sc administered 72 hrs post infection ChEMBL. 376848

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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