TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 366.477 | Formula: C21H22N2O2S
H donors: 1 H acceptors: 2 LogP: 3.3 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COCc1cccc(c1)c1csc(n1)C(c1ccccc1)(NC(=O)C)C
InChi: 1S/C21H22N2O2S/c1-15(24)23-21(2,18-10-5-4-6-11-18)20-22-19(14-26-20)17-9-7-8-16(12-17)13-25-3/h4-12,14H,13H2,1-3H3,(H,23,24)
InChiKey: OQTRJGWQATXXIE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0034	0.0224	0.0377
Schistosoma mansoni	serine/threonine protein kinase	0.0587	0.5953	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Echinococcus granulosus	GPCR family 2	0.0033	0.0215	0.036
Echinococcus multilocularis	g protein coupled receptor	0.0034	0.0224	0.0377
Schistosoma mansoni	neuropeptide receptor	0.0034	0.0224	0.0377
Echinococcus granulosus	neuropeptide Y receptor	0.0034	0.0224	0.0377
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0034	0.0224	0.0377
Echinococcus granulosus	neuropeptide FF receptor 2	0.0034	0.0224	0.0377
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0092	0.0824	0.107
Schistosoma mansoni	amine GPCR	0.0034	0.0224	0.0377
Brugia malayi	hypothetical protein	0.0034	0.0224	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Echinococcus granulosus	rhodopsin orphan GPCR	0.0034	0.0224	0.0377
Brugia malayi	hypothetical protein	0.0034	0.0224	0.0224
Echinococcus granulosus	g protein coupled receptor	0.0034	0.0224	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Loa Loa (eye worm)	STE/STE20/TAO protein kinase	0.0587	0.5953	0.7732
Echinococcus multilocularis	inhibitor of apoptosis protein	0.0054	0.043	0.0723
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.0096	0.5
Echinococcus granulosus	serine:threonine protein kinase TAO1	0.0587	0.5953	1
Echinococcus multilocularis	allatostatin A receptor	0.0034	0.0224	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0092	0.0824	0.1384
Loa Loa (eye worm)	G-protein coupled receptor	0.0034	0.0224	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Schistosoma mansoni	opsin-like receptor	0.0034	0.0224	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0032	0.021	0.0273
Entamoeba histolytica	hypothetical protein	0.0072	0.0616	1
Loa Loa (eye worm)	hypothetical protein	0.0283	0.2812	0.3652
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Brugia malayi	G protein-coupled receptor	0.0034	0.0224	0.0224
Onchocerca volvulus		0.0034	0.0224	0.1166
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0034	0.0224	0.0377
Echinococcus granulosus	7tm_1 domain containing protein	0.0034	0.0224	0.0377
Brugia malayi	hypothetical protein	0.0034	0.0224	0.0224
Echinococcus multilocularis	serine:threonine protein kinase TAO1	0.0587	0.5953	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0049	0.0387	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0175	0.0227
Schistosoma mansoni	transient receptor potential channel	0.0063	0.0529	0.0889
Echinococcus granulosus	fmrfamide receptor	0.0034	0.0224	0.0377
Echinococcus granulosus	rhodopsin orphan GPCR	0.0034	0.0224	0.0377
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0092	0.0824	0.1384
Echinococcus multilocularis	neuropeptide receptor	0.0034	0.0224	0.0377
Echinococcus granulosus	baculoviral IAP repeat containing protein	0.0054	0.043	0.0723
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0034	0.0224	0.0377
Echinococcus granulosus	rhodopsin orphan GPCR	0.0034	0.0224	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Schistosoma mansoni	tar DNA-binding protein	0.0131	0.1235	0.2075
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Schistosoma mansoni	hypothetical protein	0.0033	0.0215	0.036
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.0824	0.1384
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0494	0.0829
Entamoeba histolytica	hypothetical protein	0.0023	0.0118	0.0432
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.0224	0.0377
Schistosoma mansoni	transient receptor potential channel	0.0063	0.0529	0.0889
Loa Loa (eye worm)	hypothetical protein	0.0284	0.2822	0.3665
Echinococcus multilocularis	neuropeptide Y receptor	0.0034	0.0224	0.0377
Echinococcus multilocularis	sex peptide receptor	0.0034	0.0224	0.0377
Echinococcus multilocularis	neuropeptides capa receptor	0.0034	0.0224	0.0377
Schistosoma mansoni	hypothetical protein	0.0033	0.0215	0.036
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Schistosoma mansoni	hypothetical protein	0.0034	0.0224	0.0377
Schistosoma mansoni	amine GPCR	0.0034	0.0224	0.0377
Brugia malayi	larval opioid receptor	0.0034	0.0224	0.0224
Entamoeba histolytica	hypothetical protein	0.0072	0.0616	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0033	0.0215	0.036
Echinococcus granulosus	short transient receptor potential channel 6	0.0063	0.0529	0.0889
Echinococcus multilocularis	neuropeptide receptor A26	0.0034	0.0224	0.0377
Brugia malayi	AKH receptor	0.0034	0.0224	0.0224
Brugia malayi	hypothetical protein	0.0049	0.0387	0.0387
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0118	1
Brugia malayi	hypothetical protein	0.0034	0.0224	0.0224
Onchocerca volvulus		0.0034	0.0224	0.1166
Brugia malayi	Dopamine receptor	0.0034	0.0224	0.0224
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0034	0.0224	0.0377
Schistosoma mansoni	neuropeptide f receptor 76f	0.0034	0.0224	0.0377
Brugia malayi	hypothetical protein	0.0072	0.0616	0.0616
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0034	0.0224	0.0291
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0034	0.0224	0.0377
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0033	0.0215	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0387	0.0503
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0034	0.0224	0.0377
Echinococcus granulosus	biogenic amine 5HT receptor	0.0283	0.2812	0.4723
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0494	0.5
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0034	0.0224	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0386	0.3874	0.5032
Schistosoma mansoni	hypothetical protein	0.0054	0.043	0.0723
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.0224	0.0377
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.0224	0.0377
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0092	0.0824	0.1384
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.0224	0.0377
Leishmania major	hypothetical protein, conserved	0.0049	0.0387	0.0383
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0494	0.0829
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0034	0.0224	0.0377
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.0224	0.0377
Schistosoma mansoni	inhibitor of apoptosis protein	0.0054	0.043	0.0723
Brugia malayi	RNA, U transporter 1	0.0082	0.0728	0.0728
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0034	0.0224	0.0377
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0034	0.0224	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0864	0.1122
Brugia malayi	Serine/threonine-protein kinase SULU	0.0587	0.5953	0.5953
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0034	0.0224	0.0224
Schistosoma mansoni	tar DNA-binding protein	0.0131	0.1235	0.2075
Brugia malayi	sulfakinin receptor protein	0.0034	0.0224	0.0224
Echinococcus multilocularis	tar DNA binding protein	0.0131	0.1235	0.2075
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Echinococcus multilocularis	snurportin 1	0.0309	0.3078	0.5171
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Schistosoma mansoni	hypothetical protein	0.0033	0.0215	0.036
Loa Loa (eye worm)	neuropeptide F receptor	0.0034	0.0224	0.0291
Entamoeba histolytica	hypothetical protein	0.0072	0.0616	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0034	0.0224	0.0224
Onchocerca volvulus		0.0034	0.0224	0.1166
Schistosoma mansoni	biogenic amine receptor	0.0034	0.0224	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0243	0.0315
Brugia malayi	hypothetical protein	0.0034	0.0224	0.0224
Schistosoma mansoni	growth hormone secretagogue receptor	0.0034	0.0224	0.0377
Brugia malayi	Importin beta-1 subunit	0.0029	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Onchocerca volvulus		0.0034	0.0224	0.1166
Onchocerca volvulus		0.0034	0.0224	0.1166
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0022	0.0105	0.0176
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0034	0.0224	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0034	0.0224	0.0377
Echinococcus granulosus	tm gpcr rhodopsin	0.0034	0.0224	0.0377
Echinococcus granulosus	g protein coupled receptor	0.0034	0.0224	0.0377
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0755	0.7699	0.7699
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.0175	0.0294
Brugia malayi	hypothetical protein	0.0034	0.0224	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.006	0.0494	0.5
Leishmania major	C-8 sterol isomerase-like protein	0.0755	0.7699	1
Echinococcus multilocularis	short transient receptor potential channel 6	0.0063	0.0529	0.0889
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0034	0.0224	0.0377
Echinococcus multilocularis	g protein coupled receptor	0.0034	0.0224	0.0377
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0034	0.0224	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Echinococcus granulosus	neuropeptides capa receptor	0.0034	0.0224	0.0377
Brugia malayi	RNA recognition motif domain containing protein	0.0131	0.1235	0.1235
Echinococcus granulosus	orexin receptor type 2	0.0034	0.0224	0.0377
Echinococcus granulosus	importin subunit beta 1	0.0029	0.0175	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.006	0.0494	0.0829
Echinococcus multilocularis	transient receptor potential ion channel A	0.0092	0.0831	0.1396
Echinococcus multilocularis	serotonin receptor	0.0283	0.2812	0.4723
Onchocerca volvulus		0.0034	0.0224	0.1166
Onchocerca volvulus		0.0034	0.0224	0.1166
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0034	0.0224	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0034	0.0224	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0054	0.043	0.0559
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0104	0.0948	0.0948
Schistosoma mansoni	neuropeptide receptor	0.0034	0.0224	0.0377
Echinococcus multilocularis	dro:myosuppressin receptor	0.0034	0.0224	0.0377
Brugia malayi	RNA binding protein	0.0131	0.1235	0.1235
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0092	0.0824	0.0824
Brugia malayi	Inhibitor of Apoptosis domain containing protein	0.0054	0.043	0.043
Brugia malayi	latrophilin 2 splice variant baaae	0.0071	0.0609	0.0609
Schistosoma mansoni	transient receptor potential channel 4	0.0095	0.0864	0.1452
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0034	0.0224	0.0377
Schistosoma mansoni	transcription factor LCR-F1	0.0072	0.0616	0.1035
Brugia malayi	RE15519p	0.0034	0.0224	0.0224
Echinococcus multilocularis	short transient receptor potential channel 6	0.0063	0.0529	0.0889
Brugia malayi	Inhibitor of Apoptosis domain containing protein	0.0054	0.043	0.043
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0118	0.003
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Onchocerca volvulus		0.0034	0.0224	0.1166
Brugia malayi	putative neuropeptide receptor NPR1	0.0034	0.0224	0.0224
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.0224	0.0377
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0034	0.0224	0.0291
Schistosoma mansoni	adenoreceptor	0.0034	0.0224	0.0377
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.0224	0.0377
Onchocerca volvulus		0.0054	0.043	0.2238
Schistosoma mansoni	neuropeptide receptor	0.0034	0.0224	0.0377
Echinococcus granulosus	short transient receptor potential channel 6	0.0063	0.0529	0.0889
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0034	0.0224	0.0377
Brugia malayi	GnHR receptor homolog	0.0034	0.0224	0.0224
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.0224	0.0377
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0072	0.0616	0.1035
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Schistosoma mansoni	neuropeptide F-like receptor	0.0034	0.0224	0.0377
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0034	0.0224	0.0377
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0034	0.0224	0.0377
Schistosoma mansoni	tar DNA-binding protein	0.0131	0.1235	0.2075
Brugia malayi	hypothetical protein	0.0034	0.0224	0.0224
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0034	0.0224	0.0377
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0034	0.0224	0.1166
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.0224	0.0377
Onchocerca volvulus		0.0034	0.0224	0.1166
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Brugia malayi	G-protein coupled receptor	0.0034	0.0224	0.0224
Echinococcus multilocularis	neuropeptides capa receptor	0.0034	0.0224	0.0377
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0034	0.0224	0.0377
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0118	0.003
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0104	0.0948	0.0948
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0036	0.0243	0.0408
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0033	0.0215	0.036
Trypanosoma cruzi	PAB1-binding protein , putative	0.0049	0.0387	0.0383
Schistosoma mansoni	hypothetical protein	0.0072	0.0616	0.1035
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.0824	0.1384
Echinococcus granulosus	snurportin 1	0.0309	0.3078	0.5171
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0131	0.1235	0.1605
Echinococcus granulosus	rhodopsin orphan GPCR	0.0034	0.0224	0.0377
Schistosoma mansoni	inhibitor of apoptosis (iap) domain family member	0.0054	0.043	0.0723
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Schistosoma mansoni	opsin-like receptor	0.0034	0.0224	0.0377
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0034	0.0224	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.0224	0.0377
Echinococcus granulosus	neuropeptide receptor	0.0034	0.0224	0.0377
Echinococcus multilocularis	baculoviral IAP repeat containing protein	0.0054	0.043	0.0723
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0096	0.0161
Onchocerca volvulus		0.0034	0.0224	0.1166
Echinococcus granulosus	neuropeptide receptor A26	0.0034	0.0224	0.0377
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0034	0.0224	0.0377
Echinococcus granulosus	rhodopsin orphan GPCR	0.0034	0.0224	0.0377
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0755	0.7699	1
Echinococcus granulosus	neuropeptide receptor	0.0034	0.0224	0.0377
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0175	0.0104
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.0224	0.0377
Echinococcus granulosus	tar DNA binding protein	0.0131	0.1235	0.2075
Echinococcus granulosus	tm gpcr rhodopsin	0.0034	0.0224	0.0377
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0033	0.0215	0.036
Schistosoma mansoni	myosin xvIII	0.0034	0.0224	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Schistosoma mansoni	biogenic amine receptor	0.0034	0.0224	0.0377
Echinococcus granulosus	neuropeptide Y receptor	0.0034	0.0224	0.0377
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0034	0.0224	0.0377
Echinococcus multilocularis	g protein coupled receptor	0.0034	0.0224	0.0377
Brugia malayi	neuropeptide F receptor	0.0034	0.0224	0.0224
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0034	0.0224	0.0377
Schistosoma mansoni	hypothetical protein	0.0034	0.0224	0.0377
Brugia malayi	Dopamine receptor protein 2	0.0034	0.0224	0.0224
Brugia malayi	putative neuropeptide receptor	0.0034	0.0224	0.0224
Echinococcus granulosus	transient receptor potential gamma protein	0.0095	0.0864	0.1452
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0096	0.0124
Brugia malayi	Melatonin receptor type 1A	0.0034	0.0224	0.0224
Echinococcus granulosus	allatostatin A receptor	0.0034	0.0224	0.0377
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0104	0.0948	0.1232
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Schistosoma mansoni	hypothetical protein	0.0071	0.0609	0.1022
Plasmodium falciparum	ataxin-2 like protein, putative	0.0049	0.0387	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0034	0.0224	0.0377
Brugia malayi	hypothetical protein	0.0032	0.0206	0.0206
Brugia malayi	neuropeptide F receptor	0.0034	0.0224	0.0224
Toxoplasma gondii	LsmAD domain-containing protein	0.0049	0.0387	0.7325
Brugia malayi	Transient-receptor-potential like protein	0.0036	0.0243	0.0243
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.006	0.0494	0.0523
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.0224	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Schistosoma mansoni	hypothetical protein	0.0309	0.3078	0.5171
Echinococcus granulosus	neuropeptides capa receptor	0.0034	0.0224	0.0377
Echinococcus multilocularis	fmrfamide receptor	0.0034	0.0224	0.0377
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0034	0.0224	0.0377
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.0175	0.1991
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.0224	0.0377
Echinococcus multilocularis	neuropeptide receptor	0.0034	0.0224	0.0377
Schistosoma mansoni	hypothetical protein	0.0034	0.0224	0.0377
Schistosoma mansoni	ran	0.0021	0.0096	0.0161
Schistosoma mansoni	hypothetical protein	0.0033	0.0215	0.036
Loa Loa (eye worm)	neuropeptide F receptor	0.0034	0.0224	0.0291
Onchocerca volvulus		0.0034	0.0224	0.1166
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Brugia malayi	G-protein coupled receptor	0.0034	0.0224	0.0224
Onchocerca volvulus		0.0034	0.0224	0.1166
Echinococcus multilocularis	neuropeptide s receptor	0.0034	0.0224	0.0377
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0034	0.0224	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Entamoeba histolytica	hypothetical protein	0.0072	0.0616	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.006	0.0494	0.0829
Echinococcus granulosus	neuropeptide s receptor	0.0034	0.0224	0.0377
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0034	0.0224	0.0377
Echinococcus granulosus	7TM GPCR rhodopsin	0.0034	0.0224	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0175	0.0104
Onchocerca volvulus		0.0034	0.0224	0.1166
Brugia malayi	Latrophilin receptor protein 2	0.0033	0.0215	0.0215
Schistosoma mansoni	importin beta-1	0.0029	0.0175	0.0294
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0034	0.0224	0.1166
Schistosoma mansoni	biogenic amine receptor	0.0034	0.0224	0.0377
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0034	0.0224	0.0377
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0034	0.0224	0.0377
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0034	0.0224	0.0377
Echinococcus granulosus	g protein coupled receptor	0.0034	0.0224	0.0377
Echinococcus granulosus	rhodopsin orphan GPCR	0.0034	0.0224	0.0377
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0283	0.2812	0.4723
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0022	0.0105	0.0176
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0118	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0034	0.0224	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0948	0.1232
Plasmodium falciparum	ataxin-2 like protein, putative	0.0049	0.0387	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.0824	0.1384
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0096	0.0161
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0033	0.0215	0.0279
Toxoplasma gondii	aldehyde dehydrogenase	0.006	0.0494	1
Brugia malayi	hypothetical protein	0.0587	0.5953	0.5953
Schistosoma mansoni	neuropeptide F-like receptor	0.0034	0.0224	0.0377
Brugia malayi	N-terminal motif family protein	0.0198	0.1922	0.1922
Brugia malayi	Serotonin receptor	0.0034	0.0224	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Trypanosoma cruzi	PAB1-binding protein , putative	0.0049	0.0387	0.0383
Plasmodium vivax	importin-beta 2, putative	0.0029	0.0175	0.2717
Echinococcus multilocularis	serotonin receptor	0.0283	0.2812	0.4723
Echinococcus granulosus	serotonin receptor	0.0034	0.0224	0.0377
Schistosoma mansoni	tar DNA-binding protein	0.0131	0.1235	0.2075
Loa Loa (eye worm)	hypothetical protein	0.0054	0.043	0.0559
Brugia malayi	follicle stimulating hormone receptor	0.0034	0.0224	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0198	0.1922	0.2497
Schistosoma mansoni	transient receptor potential channel	0.0095	0.0864	0.1452
Brugia malayi	hypothetical protein	0.0034	0.0224	0.0224
Echinococcus granulosus	TRP transient receptor potential channel	0.0036	0.0243	0.0408
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0034	0.0224	0.0377
Echinococcus granulosus	rhodopsin orphan GPCR	0.0034	0.0224	0.0377
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0755	0.7699	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0034	0.0224	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0755	0.7699	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.0224	0.0377
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0198	0.1922	1
Echinococcus multilocularis	orexin receptor type 2	0.0034	0.0224	0.0377
Loa Loa (eye worm)	G-protein coupled receptor	0.0034	0.0224	0.0291
Echinococcus multilocularis	neuropeptide Y receptor	0.0034	0.0224	0.0377
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0034	0.0224	0.0224
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0034	0.0224	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Onchocerca volvulus		0.0034	0.0224	0.1166
Schistosoma mansoni	amine GPCR	0.0034	0.0224	0.0377
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0309	0.3078	0.3998
Schistosoma mansoni	amine GPCR	0.0034	0.0224	0.0377
Schistosoma mansoni	tar DNA-binding protein	0.0131	0.1235	0.2075
Schistosoma mansoni	amine GPCR	0.0034	0.0224	0.0377
Echinococcus granulosus	biogenic amine 5HT receptor	0.0034	0.0224	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0034	0.0224	0.0291
Brugia malayi	hypothetical protein	0.0034	0.0224	0.0224
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0494	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.0224	0.0377
Trypanosoma brucei	PAB1-binding protein , putative	0.0049	0.0387	0.0383
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0034	0.0224	0.0377
Onchocerca volvulus		0.0034	0.0224	0.1166
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0034	0.0224	0.0377
Loa Loa (eye worm)	hypothetical protein	0.006	0.0496	0.0645
Loa Loa (eye worm)	melatonin receptor type 1A	0.0034	0.0224	0.0291
Echinococcus multilocularis	fmrfamide receptor	0.0034	0.0224	0.0377
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0072	0.0616	0.1035
Echinococcus multilocularis	G protein coupled receptor 139	0.0034	0.0224	0.0377
Brugia malayi	G protein-coupled receptor F59B2.13	0.0034	0.0224	0.0224
Echinococcus granulosus	inhibitor of apoptosis protein	0.0054	0.043	0.0723
Echinococcus granulosus	G protein coupled receptor 139	0.0034	0.0224	0.0377
Echinococcus multilocularis	transient receptor potential gamma protein	0.0095	0.0864	0.1452
Echinococcus granulosus	g-protein coupled receptor	0.0034	0.0224	0.0377
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0118	1
Brugia malayi	hypothetical protein	0.0034	0.0224	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Onchocerca volvulus	Deterin homolog	0.0054	0.043	0.2238
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0215	0.0279
Loa Loa (eye worm)	TYRA-2 protein	0.0034	0.0224	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Schistosoma mansoni	hypothetical protein	0.0034	0.0224	0.0377
Schistosoma mansoni	ran	0.0021	0.0096	0.0161
Brugia malayi	ORL1-like opioid receptor	0.0034	0.0224	0.0224
Schistosoma mansoni	hypothetical protein	0.0022	0.0105	0.0176
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0034	0.0224	0.0377
Echinococcus granulosus	hypothetical protein	0.0034	0.0224	0.0377
Brugia malayi	TAR-binding protein	0.0131	0.1235	0.1235
Plasmodium falciparum	importin beta, putative	0.0029	0.0175	0.2717
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0034	0.0224	0.0377
Loa Loa (eye worm)	RNA binding protein	0.0131	0.1235	0.1605
Onchocerca volvulus		0.0034	0.0224	0.1166
Schistosoma mansoni	opsin-like receptor	0.0034	0.0224	0.0377
Echinococcus granulosus	dro:myosuppressin receptor	0.0034	0.0224	0.0377
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0034	0.0224	0.0377
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0096	0.0096
Schistosoma mansoni	histamine h1 receptor	0.0034	0.0224	0.0377
Brugia malayi	Dopamine receptor protein 1	0.0034	0.0224	0.0224
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0034	0.0224	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Echinococcus granulosus	transient receptor potential ion channel A	0.0092	0.0831	0.1396
Loa Loa (eye worm)	TAR-binding protein	0.0131	0.1235	0.1605
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0609	0.0791
Echinococcus granulosus	somatostatin receptor	0.0034	0.0224	0.0377
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0494	0.5
Schistosoma mansoni	neuropeptide receptor	0.0034	0.0224	0.0377
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0033	0.0215	0.036
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0034	0.0224	0.0377
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.0224	0.0377
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.0224	0.0377
Echinococcus multilocularis	GPCR, family 2	0.0033	0.0215	0.036
Echinococcus granulosus	sex peptide receptor	0.0034	0.0224	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0291
Onchocerca volvulus		0.0034	0.0224	0.1166
Echinococcus multilocularis	g-protein coupled receptor	0.0034	0.0224	0.0377
Echinococcus granulosus	tm gpcr rhodopsin	0.0034	0.0224	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0283	0.2812	0.3652
Echinococcus multilocularis	somatostatin receptor	0.0034	0.0224	0.0377
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0092	0.0824	0.1384

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	35.4813 uM	PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2354407

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1756935