Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | carbonic anhydrase | 0.1892 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1033 | 0.2 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1033 | 0.2 | 0.5 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1892 | 1 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1033 | 0.2 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1033 | 0.2 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.1033 | 0.2 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0818 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0818 | 0 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1033 | 0.2 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.1074 | 0.2381 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1033 | 0.2 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1033 | 0.2 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1033 | 0.2 | 0.5 |
Leishmania major | carbonic anhydrase family protein, putative | 0.1892 | 1 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1892 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.