Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.2003 | 0.3002 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.2003 | 0.3002 | 0.3002 |
Echinococcus granulosus | carbonic anhydrase II | 0.2003 | 0.3002 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.2003 | 0.3002 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.2003 | 0.3002 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2003 | 0.3002 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.2003 | 0.3002 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.4728 | 1 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0834 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.2045 | 0.311 | 0.5 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.4728 | 1 | 0.5 |
Leishmania major | carbonic anhydrase family protein, putative | 0.4728 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.4728 | 1 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.2003 | 0.3002 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.2003 | 0.3002 | 0.3002 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.2003 | 0.3002 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0834 | 0 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2003 | 0.3002 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.2684 | 0.475 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.2045 | 0.311 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.