Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | paired box 8 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Pax transcription factor protein 2 | Get druggable targets OG5_139945 | All targets in OG5_139945 |
Onchocerca volvulus | Get druggable targets OG5_139945 | All targets in OG5_139945 | |
Loa Loa (eye worm) | pax transcription factor protein 2 | Get druggable targets OG5_139945 | All targets in OG5_139945 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0253 | 0.0402 | 0.5 |
Brugia malayi | cell division control protein 2 homolog | 0.0253 | 0.0402 | 0.0222 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0253 | 0.0402 | 0.0222 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0253 | 0.0402 | 0.0222 |
Trichomonas vaginalis | cyclins, putative | 0.0169 | 0.0185 | 0.0557 |
Echinococcus multilocularis | dual specificity serine:threonine tyrosine | 0.1078 | 0.2561 | 0.2421 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.0185 | 0.0185 |
Trichomonas vaginalis | cyclins, putative | 0.0169 | 0.0185 | 0.0557 |
Trichomonas vaginalis | cyclin B, putative | 0.0169 | 0.0185 | 0.0557 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0253 | 0.0402 | 0.1422 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0253 | 0.0402 | 0.1422 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0253 | 0.0402 | 1 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.3921 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.1078 | 0.2561 | 0.2421 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0253 | 0.0402 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0253 | 0.0402 | 0.1422 |
Schistosoma mansoni | dual specificity serine/threonine tyrosine kinase | 0.1078 | 0.2561 | 0.2421 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0253 | 0.0402 | 0.0222 |
Trichomonas vaginalis | cyclin B, putative | 0.0169 | 0.0185 | 0.0557 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0253 | 0.0402 | 1 |
Giardia lamblia | Kinase, CMGC CDK | 0.0253 | 0.0402 | 0.0916 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0253 | 0.0402 | 1 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.3921 | 1 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0253 | 0.0402 | 0.0222 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.3921 | 1 | 1 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0253 | 0.0402 | 0.0222 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.0334 | 0.0334 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.3921 | 1 | 1 |
Plasmodium falciparum | protein kinase 5 | 0.0253 | 0.0402 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0253 | 0.0402 | 0.0222 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.0185 | 0.0185 |
Schistosoma mansoni | serine/threonine protein kinase | 0.3921 | 1 | 1 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0253 | 0.0402 | 1 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0253 | 0.0402 | 0.0222 |
Loa Loa (eye worm) | TTK protein kinase | 0.1078 | 0.2561 | 0.2561 |
Trichomonas vaginalis | cyclin B, putative | 0.0169 | 0.0185 | 0.0557 |
Trichomonas vaginalis | cyclin A, putative | 0.0169 | 0.0185 | 0.0557 |
Giardia lamblia | Kinase, CMGC CDK | 0.0253 | 0.0402 | 0.0916 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0253 | 0.0402 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0253 | 0.0402 | 0.0402 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0291 | 0.0502 | 0.0502 |
Brugia malayi | Pax transcription factor protein 2 | 0.0291 | 0.0502 | 0.0323 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0253 | 0.0402 | 0.0402 |
Trichomonas vaginalis | cyclins, putative | 0.0169 | 0.0185 | 0.0557 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0253 | 0.0402 | 1 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0253 | 0.0402 | 1 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.3921 | 1 | 1 |
Echinococcus granulosus | cyclin dependent kinase | 0.0253 | 0.0402 | 0.0222 |
Echinococcus granulosus | dual specificity serine:threonine tyrosine | 0.1078 | 0.2561 | 0.2421 |
Onchocerca volvulus | 0.0291 | 0.0502 | 0.0323 | |
Trichomonas vaginalis | CAMK family protein kinase | 0.1078 | 0.2561 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1078 | 0.2561 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0253 | 0.0402 | 0.0402 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0253 | 0.0402 | 0.0222 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.3921 | 1 | 1 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0253 | 0.0402 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0169 | 0.0185 | 0.0557 |
Brugia malayi | Protein kinase domain containing protein | 0.0253 | 0.0402 | 0.0222 |
Onchocerca volvulus | Dual specificity protein kinase TTK homolog | 0.1078 | 0.2561 | 0.2421 |
Plasmodium vivax | protein kinase Crk2 | 0.0253 | 0.0402 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0253 | 0.0402 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0169 | 0.0185 | 0.0557 |
Giardia lamblia | Kinase, TTK | 0.1078 | 0.2561 | 1 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0253 | 0.0402 | 0.0222 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (functional) | = 6.6 uM | PubChem BioAssay. HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.