Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0058 | 0.0044 | 0.0351 |
Onchocerca volvulus | 0.0096 | 0.126 | 1 | |
Onchocerca volvulus | 0.0096 | 0.126 | 1 | |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0096 | 0.126 | 0.126 |
Brugia malayi | protein-tyrosine kinase | 0.0096 | 0.126 | 0.126 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0096 | 0.126 | 0.126 |
Echinococcus granulosus | c src tyrosine kinase | 0.0096 | 0.126 | 0.126 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0096 | 0.126 | 0.126 |
Onchocerca volvulus | 0.0096 | 0.126 | 1 | |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0096 | 0.126 | 0.126 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0096 | 0.126 | 0.126 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0096 | 0.126 | 0.126 |
Brugia malayi | Protein kinase domain containing protein | 0.0096 | 0.126 | 0.126 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0096 | 0.126 | 0.126 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0096 | 0.126 | 0.126 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0097 | 0.1305 | 0.1305 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0096 | 0.126 | 0.126 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0096 | 0.126 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0096 | 0.126 | 0.126 |
Brugia malayi | hypothetical protein | 0.0096 | 0.126 | 0.126 |
Brugia malayi | SRC-1 | 0.0096 | 0.126 | 0.126 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0096 | 0.126 | 0.126 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0096 | 0.126 | 0.126 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.126 | 0.126 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.126 | 0.126 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0096 | 0.126 | 0.126 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0096 | 0.126 | 0.126 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.126 | 0.126 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0096 | 0.126 | 0.126 |
Schistosoma mansoni | protein kinase | 0.0369 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0096 | 0.126 | 0.126 |
Brugia malayi | Protein kinase domain containing protein | 0.0096 | 0.126 | 0.126 |
Loa Loa (eye worm) | TK protein kinase | 0.0096 | 0.126 | 0.126 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0096 | 0.126 | 0.126 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0096 | 0.126 | 0.126 |
Echinococcus granulosus | tyrosine kinase | 0.0096 | 0.126 | 0.126 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0096 | 0.126 | 0.126 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0096 | 0.126 | 0.126 |
Brugia malayi | Protein kinase domain containing protein | 0.0096 | 0.126 | 0.126 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0096 | 0.126 | 0.126 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0096 | 0.126 | 0.126 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0096 | 0.126 | 0.126 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0096 | 0.126 | 0.126 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0096 | 0.126 | 0.126 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.126 | 0.126 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0096 | 0.126 | 0.126 |
Onchocerca volvulus | 0.0096 | 0.126 | 1 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0096 | 0.126 | 0.126 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0096 | 0.126 | 0.126 |
Loa Loa (eye worm) | SRC-1 | 0.0096 | 0.126 | 0.126 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0096 | 0.126 | 0.126 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0096 | 0.126 | 0.126 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0096 | 0.126 | 0.126 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0096 | 0.126 | 0.126 |
Entamoeba histolytica | protein kinase, putative | 0.0058 | 0.0044 | 0.0351 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0096 | 0.126 | 0.126 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.126 | 0.126 |
Echinococcus granulosus | tyrosine kinase | 0.0096 | 0.126 | 0.126 |
Brugia malayi | Protein kinase domain containing protein | 0.0096 | 0.126 | 0.126 |
Brugia malayi | SH2 domain containing protein | 0.0096 | 0.126 | 0.126 |
Echinococcus granulosus | dual specificity mitogen activated protein | 0.0369 | 1 | 1 |
Loa Loa (eye worm) | STE/STE7/MEK7 protein kinase | 0.0369 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0096 | 0.126 | 0.126 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0096 | 0.126 | 0.126 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0096 | 0.126 | 0.126 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0096 | 0.126 | 0.126 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0096 | 0.126 | 0.126 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.126 | 0.126 |
Onchocerca volvulus | 0.0096 | 0.126 | 1 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0096 | 0.126 | 0.126 |
Loa Loa (eye worm) | STE/STE7/MEK7 protein kinase | 0.0369 | 1 | 1 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0096 | 0.126 | 0.126 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.126 | 0.126 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0096 | 0.126 | 0.126 |
Echinococcus multilocularis | tyrosine kinase | 0.0096 | 0.126 | 0.126 |
Onchocerca volvulus | 0.0096 | 0.126 | 1 | |
Brugia malayi | SH2 domain containing protein | 0.0096 | 0.126 | 0.126 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0096 | 0.126 | 0.126 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0096 | 0.126 | 0.126 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0096 | 0.126 | 0.126 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0096 | 0.126 | 0.126 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0096 | 0.126 | 0.126 |
Echinococcus multilocularis | dual specificity mitogen activated protein | 0.0369 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AbsAC40 (functional) | > 15 uM | PubChem BioAssay. HTS for the detection of C. neoformans cell lysis via adenylate kinase (AK) release Measured in Microorganism System Using Plate Reader - 2162-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.