Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0271 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0271 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0271 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0271 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0271 | 0 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0271 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0271 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0271 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0271 | 0 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0271 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0271 | 0 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.2866 | 0.9477 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0271 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0271 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0271 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0271 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0271 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0271 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0271 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0271 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0271 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0271 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0271 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0271 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0271 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0271 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0271 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0271 | 0 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0271 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2738 | 0.9011 | 0.9507 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.2866 | 0.9477 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0271 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0271 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0271 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 50 uM | Inhibition of human GAL4-DBD-fused ERRalpha-LBD transcriptional activity transfected in human 293FT cells assessed as disruption of interaction with PGC-1alpha after 24 hrs by dual luciferase reporter gene assay | ChEMBL. | 23656512 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.