Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.0023 | 0.0017 |
Onchocerca volvulus | 0.0717 | 0.0638 | 0.0219 | |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.0717 | 0.0638 | 0.0633 |
Loa Loa (eye worm) | hypothetical protein | 0.0717 | 0.0638 | 0.0633 |
Onchocerca volvulus | 0.0717 | 0.0638 | 0.0219 | |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0052 | 0.0024 | 0.0378 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0026 | 0 | 0.5 |
Toxoplasma gondii | protease inhibitor PI2 | 0.0489 | 0.0428 | 0.6682 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0105 | 0.0074 | 0.1022 |
Loa Loa (eye worm) | hypothetical protein | 1.0851 | 1 | 1 |
Echinococcus multilocularis | expressed protein | 0.0489 | 0.0428 | 0.6343 |
Loa Loa (eye worm) | hypothetical protein | 0.0717 | 0.0638 | 0.0633 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0753 | 0.0672 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0131 | 0.0097 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0489 | 0.0428 | 0.0423 |
Loa Loa (eye worm) | hypothetical protein | 0.0717 | 0.0638 | 0.0633 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0052 | 0.0024 | 0.0279 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0753 | 0.0672 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0023 | 0.0256 |
Echinococcus multilocularis | agrin | 0.0489 | 0.0428 | 0.6343 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0105 | 0.0074 | 0.1022 |
Schistosoma mansoni | hypothetical protein | 0.0336 | 0.0287 | 0.4219 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0118 | 0.0085 | 0.8342 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.0038 | 0.0482 |
Trypanosoma cruzi | MFS transporter, putative | 0.0717 | 0.0638 | 1 |
Brugia malayi | Kazal-type serine protease inhibitor domain containing protein | 0.0489 | 0.0428 | 0.0423 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0131 | 0.0097 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0052 | 0.0024 | 0.0019 |
Plasmodium falciparum | thioredoxin reductase | 0.0052 | 0.0024 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0753 | 0.0672 | 1 |
Schistosoma mansoni | follistatin | 0.0489 | 0.0428 | 0.6343 |
Loa Loa (eye worm) | hypothetical protein | 0.0489 | 0.0428 | 0.0423 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0066 | 0.0038 | 0.0508 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0023 | 0.0256 |
Onchocerca volvulus | 0.0717 | 0.0638 | 0.0219 | |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.0038 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0052 | 0.0024 | 0.0019 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.0717 | 0.0638 | 0.0633 |
Echinococcus granulosus | Solute carrier organic anion transporter family | 0.0717 | 0.0638 | 0.9492 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0066 | 0.0038 | 0.0482 |
Toxoplasma gondii | Kazal-type serine protease inhibitor domain-containing protein | 0.0489 | 0.0428 | 0.6682 |
Onchocerca volvulus | 0.0717 | 0.0638 | 0.0219 | |
Plasmodium falciparum | glutathione reductase | 0.0052 | 0.0024 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0074 | 0.0068 |
Loa Loa (eye worm) | kazal-type serine protease inhibitor domain-containing protein | 0.0489 | 0.0428 | 0.0423 |
Toxoplasma gondii | Kazal-type serine protease inhibitor domain-containing protein | 0.0489 | 0.0428 | 0.6682 |
Echinococcus multilocularis | follistatin | 0.0489 | 0.0428 | 0.6343 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0105 | 0.0074 | 0.1022 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.0038 | 0.5 |
Brugia malayi | secreted modular calcium-binding protein 1 | 0.0489 | 0.0428 | 0.0423 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0023 | 0.0256 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0052 | 0.0024 | 1 |
Toxoplasma gondii | Kazal-type serine protease inhibitor domain-containing protein | 0.0489 | 0.0428 | 0.6682 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0052 | 0.0024 | 0.0279 |
Onchocerca volvulus | Putative organic anion transporter | 0.0717 | 0.0638 | 0.0219 |
Toxoplasma gondii | Kazal-type serine protease inhibitor domain-containing protein | 0.0489 | 0.0428 | 0.6682 |
Loa Loa (eye worm) | sodium-independent organic anion transporter | 0.0717 | 0.0638 | 0.0633 |
Loa Loa (eye worm) | hypothetical protein | 0.0717 | 0.0638 | 0.0633 |
Leishmania major | trypanothione reductase | 0.0052 | 0.0024 | 0.6402 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0131 | 0.0097 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0131 | 0.0097 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0052 | 0.0024 | 0.0294 |
Brugia malayi | SPARC precursor | 0.0489 | 0.0428 | 0.0423 |
Echinococcus granulosus | snurportin 1 | 0.0336 | 0.0287 | 0.4219 |
Schistosoma mansoni | organic anion transporter | 0.0717 | 0.0638 | 0.9492 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0118 | 0.0085 | 0.8342 |
Entamoeba histolytica | hypothetical protein | 0.0026 | 0 | 0.5 |
Onchocerca volvulus | 0.0717 | 0.0638 | 0.0219 | |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0066 | 0.0038 | 1 |
Brugia malayi | Kazal-type serine protease inhibitor domain containing protein | 0.0489 | 0.0428 | 0.0423 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0118 | 0.0085 | 0.8342 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.0038 | 0.5 |
Echinococcus granulosus | follistatin | 0.0489 | 0.0428 | 0.6343 |
Brugia malayi | hypothetical protein | 0.0717 | 0.0638 | 0.0633 |
Brugia malayi | RNA, U transporter 1 | 0.0089 | 0.0059 | 0.0054 |
Echinococcus granulosus | agrin | 0.0489 | 0.0428 | 0.6343 |
Echinococcus multilocularis | Solute carrier organic anion transporter family | 0.0717 | 0.0638 | 0.9492 |
Echinococcus multilocularis | organic anion transporting polypeptide 30B | 0.0717 | 0.0638 | 0.9492 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0336 | 0.0287 | 0.0281 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.0023 | 0.0017 |
Loa Loa (eye worm) | agrin synaptic family protein | 0.0489 | 0.0428 | 0.0423 |
Onchocerca volvulus | Putative organic anion transporter | 1.0851 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0023 | 0.0256 |
Echinococcus granulosus | organic anion transporting polypeptide 30B | 0.0717 | 0.0638 | 0.9492 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0118 | 0.0085 | 0.8342 |
Brugia malayi | Kazal-type serine protease inhibitor domain containing protein | 0.0489 | 0.0428 | 0.0423 |
Loa Loa (eye worm) | hypothetical protein | 0.0717 | 0.0638 | 0.0633 |
Onchocerca volvulus | Putative organic anion transporter | 0.0717 | 0.0638 | 0.0219 |
Loa Loa (eye worm) | hypothetical protein | 0.0489 | 0.0428 | 0.0423 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0026 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0118 | 0.0085 | 0.8342 |
Trypanosoma brucei | trypanothione reductase | 0.0052 | 0.0024 | 1 |
Schistosoma mansoni | agrin | 0.0489 | 0.0428 | 0.6343 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0105 | 0.0074 | 0.1022 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0074 | 0.0068 |
Brugia malayi | Kazal-type serine protease inhibitor domain containing protein | 0.0489 | 0.0428 | 0.0423 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.0717 | 0.0638 | 0.0633 |
Trichomonas vaginalis | importin beta-1, putative | 0.0026 | 0 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.0038 | 0.0482 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0023 | 0.0256 |
Loa Loa (eye worm) | hypothetical protein | 0.0489 | 0.0428 | 0.0423 |
Echinococcus multilocularis | snurportin 1 | 0.0336 | 0.0287 | 0.4219 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0066 | 0.0038 | 0.0482 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0023 | 0.0256 |
Schistosoma mansoni | organic anion transporter | 0.0717 | 0.0638 | 0.9492 |
Plasmodium vivax | glutathione reductase, putative | 0.0052 | 0.0024 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0066 | 0.0038 | 0.185 |
Toxoplasma gondii | transporter, major facilitator family protein | 0.0717 | 0.0638 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0717 | 0.0638 | 0.0633 |
Loa Loa (eye worm) | glutathione reductase | 0.0052 | 0.0024 | 0.0019 |
Brugia malayi | glutathione reductase | 0.0052 | 0.0024 | 0.0019 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0023 | 0.0256 |
Brugia malayi | hypothetical protein | 0.0717 | 0.0638 | 0.0633 |
Mycobacterium tuberculosis | Probable reductase | 0.0118 | 0.0085 | 0.8342 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0105 | 0.0074 | 0.1022 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0 % | Inhibition of LTB4 biosynthesis by porcine leukocytes at LTA4 hydrolase level at a concentration of 2*10e-5 M | ChEMBL. | 1324315 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.