TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 312.321 | Formula: C20H12N2O2
H donors: 1 H acceptors: 2 LogP: 4.4 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: O=c1oc2ccccc2cc1c1nc2c([nH]1)cc1c(c2)cccc1
InChi: 1S/C20H12N2O2/c23-20-15(9-14-7-3-4-8-18(14)24-20)19-21-16-10-12-5-1-2-6-13(12)11-17(16)22-19/h1-11H,(H,21,22)
InChiKey: PSDFEUWSFAFMEJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0097	0.0874	1
Schistosoma mansoni	hypothetical protein	0.0019	0.0071	0.0185
Brugia malayi	AMP-binding enzyme family protein	0.0029	0.017	0.0461
Entamoeba histolytica	cyclin, putative	0.0231	0.226	1
Echinococcus granulosus	cyclins	0.0119	0.1108	0.2895
Toxoplasma gondii	LsmAD domain-containing protein	0.0029	0.0174	0.1279
Echinococcus multilocularis	sterol regulatory element binding protein	0.0051	0.0401	0.0401
Entamoeba histolytica	hypothetical protein	0.0043	0.0323	0.0733
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0053	0.0418	0.1134
Schistosoma mansoni	cyclins	0.0119	0.1108	0.2895
Entamoeba histolytica	cyclin C, putative	0.0029	0.0172	0.0009
Schistosoma mansoni	cyclin B3	0.0369	0.3688	0.9634
Schistosoma mansoni	cyclin l	0.0029	0.0172	0.0449
Entamoeba histolytica	cell division protein kinase 2, putative	0.0097	0.0874	0.337
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0418	0.1093
Loa Loa (eye worm)	cyclin domain-containing protein	0.0369	0.3688	1
Echinococcus granulosus	GPCR family 2	0.0019	0.0071	0.0185
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0071	0.0071
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0299	0.0812
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0174	0.0469
Plasmodium falciparum	cyclin	0.0119	0.1108	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0174	0.099
Echinococcus granulosus	cyclin k	0.0029	0.0172	0.0449
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0029	0.0172	0.0466
Mycobacterium ulcerans	hypothetical protein	0.0029	0.017	1
Echinococcus multilocularis	cyclin G2	0.0029	0.0172	0.0172
Trichomonas vaginalis	cyclins, putative	0.0231	0.226	1
Schistosoma mansoni	Cyclin fold protein	0.0029	0.0172	0.0449
Echinococcus granulosus	cyclins	0.0119	0.1108	0.2895
Brugia malayi	isocitrate dehydrogenase	0.0019	0.0071	0.0193
Plasmodium vivax	hypothetical protein, conserved	0.0029	0.0172	0.1253
Echinococcus multilocularis	protein patched	0.0051	0.0401	0.0401
Toxoplasma gondii	cyclin, N-terminal domain-containing protein	0.0029	0.0172	0.1253
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0174	0.0469
Toxoplasma gondii	cyclin 4, putative	0.0029	0.0172	0.1253
Onchocerca volvulus	Cyclin L homolog	0.0029	0.0172	0.076
Trichomonas vaginalis	cyclins, putative	0.0231	0.226	1
Echinococcus multilocularis	cyclins	0.0119	0.1108	0.1108
Entamoeba histolytica	cyclin, domain containing protein	0.0029	0.0172	0.0009
Trichomonas vaginalis	cyclins, putative	0.0119	0.1108	0.4486
Entamoeba histolytica	cyclin, putative	0.0119	0.1108	0.4491
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0029	0.017	1
Trypanosoma cruzi	cyclin, putative	0.0231	0.226	1
Schistosoma mansoni	hypothetical protein	0.0049	0.0382	0.0999
Trichomonas vaginalis	CMGC family protein kinase	0.0097	0.0874	0.3364
Echinococcus multilocularis	cyclin G2	0.0029	0.0172	0.0172
Brugia malayi	Niemann-Pick C1 protein precursor	0.0119	0.1103	0.2991
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0013	0.0008	0.0008
Trichomonas vaginalis	cyclin B, putative	0.0119	0.1108	0.4486
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0097	0.0874	0.2284
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.0369	0.3688	0.9634
Plasmodium falciparum	acyl-CoA synthetase	0.0021	0.0095	0.0231
Entamoeba histolytica	hypothetical protein	0.0029	0.0172	0.0009
Echinococcus multilocularis	Niemann Pick C1 protein	0.0119	0.1103	0.1103
Loa Loa (eye worm)	hypothetical protein	0.0029	0.017	0.0461
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0231	0.226	0.6127
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0097	0.0874	0.2371
Mycobacterium ulcerans	acyl-CoA synthetase	0.0029	0.017	1
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0021	0.0095	0.5
Trichomonas vaginalis	cyclin B3, putative	0.0119	0.1108	0.4486
Trypanosoma brucei	mitotic cyclin	0.0029	0.0172	0.046
Echinococcus granulosus	cyclin B	0.0231	0.226	0.5903
Trypanosoma brucei	cdc2-related kinase 1	0.0097	0.0874	0.367
Schistosoma mansoni	hypothetical protein	0.0013	0.0008	0.0022
Echinococcus multilocularis	Cyclin L1	0.0029	0.0172	0.0172
Trypanosoma brucei	cyclin dependent kinase-binding protein, putative	0.0029	0.0172	0.046
Echinococcus granulosus	cyclin G2	0.0029	0.0172	0.0449
Echinococcus multilocularis	cyclin B3 1	0.0119	0.1108	0.1108
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0029	0.0172	0.0466
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0071	0.0071
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.0418	0.1093
Trypanosoma cruzi	cyclin 9, putative	0.0029	0.0172	0.046
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0097	0.0874	0.367
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.002	0.0083	0.1199
Schistosoma mansoni	cyclin G	0.0029	0.0172	0.0449
Trichomonas vaginalis	cyclin D, putative	0.0119	0.1108	0.4486
Brugia malayi	cell division control protein 2 homolog	0.0097	0.0874	0.2371
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.0323	0.0844
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0029	0.017	0.5
Plasmodium vivax	acyl-CoA synthetase, putative	0.0021	0.0095	0.0298
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.0418	0.1093
Echinococcus granulosus	cyclins	0.0119	0.1108	0.2895
Entamoeba histolytica	hypothetical protein	0.0043	0.0323	0.0733
Loa Loa (eye worm)	hypothetical protein	0.0231	0.226	0.6127
Leishmania major	4-coumarate:coa ligase-like protein	0.0029	0.017	0.0451
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.02	0.1938	0.8576
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0095	0.0258
Trypanosoma brucei	mitotic cyclin 6	0.0231	0.226	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0172	0.0466
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0369	0.3688	1
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0121	0.1122	0.2931
Echinococcus multilocularis	cyclins	0.0119	0.1108	0.1108
Echinococcus multilocularis	cyclin dependent kinase 5	0.0097	0.0874	0.0874
Schistosoma mansoni	cyclin G2	0.0029	0.0172	0.0449
Mycobacterium ulcerans	acyl-CoA synthetase	0.0029	0.017	1
Echinococcus granulosus	cyclin y	0.0029	0.0172	0.0449
Echinococcus granulosus	expressed conserved protein	0.0112	0.1029	0.2687
Giardia lamblia	Kinase, CMGC CDK	0.0097	0.0874	0.3364
Onchocerca volvulus	Protein CNPPD1 homolog	0.0029	0.0172	0.076
Brugia malayi	AMP-binding enzyme family protein	0.0029	0.017	0.0461
Loa Loa (eye worm)	cyclin domain-containing protein	0.0029	0.0172	0.0466
Leishmania major	mitotic cyclin, putative	0.0029	0.0172	0.046
Trichomonas vaginalis	conserved hypothetical protein	0.0119	0.1108	0.4486
Echinococcus multilocularis	expressed conserved protein	0.0112	0.1029	0.1029
Echinococcus multilocularis	geminin	0.0382	0.3829	0.3829
Echinococcus multilocularis	cyclin	0.0029	0.0172	0.0172
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.002	0.0083	0.1199
Schistosoma mansoni	hypothetical protein	0.0382	0.3829	1
Plasmodium vivax	cyclin homologue, putative	0.0029	0.0172	0.1253
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0051	0.0401	0.1088
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0095	0.0258
Schistosoma mansoni	hypothetical protein	0.0049	0.0382	0.0999
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.0418	0.0418
Schistosoma mansoni	hypothetical protein	0.0049	0.0382	0.0999
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0029	0.017	1
Entamoeba histolytica	cyclin, domain containing protein	0.0029	0.0172	0.0009
Loa Loa (eye worm)	cyclin fold protein 1 variant b	0.0029	0.0172	0.0466
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0418	0.1093
Echinococcus multilocularis	oligomeric golgi complex subunit 3	0.0029	0.0172	0.0172
Echinococcus granulosus	sterol regulatory element binding protein	0.0051	0.0401	0.1048
Schistosoma mansoni	hypothetical protein	0.0049	0.0382	0.0999
Trichomonas vaginalis	cyclin B, putative	0.0231	0.226	1
Echinococcus granulosus	cyclins	0.0119	0.1108	0.2895
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1103	0.2991
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0029	0.0172	0.0449
Schistosoma mansoni	hypothetical protein	0.0019	0.0071	0.0185
Trichomonas vaginalis	cyclins, putative	0.0231	0.226	1
Onchocerca volvulus		0.0029	0.0172	0.076
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0071	0.0192
Trypanosoma cruzi	mitotic cyclin, putative	0.0029	0.0172	0.046
Loa Loa (eye worm)	cyclin C	0.0029	0.0172	0.0466
Onchocerca volvulus		0.0231	0.226	1
Leishmania major	mitotic cyclin, putative	0.0029	0.0172	0.046
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0172	0.0466
Giardia lamblia	Hypothetical protein	0.0119	0.1108	0.4486
Echinococcus granulosus	cyclin	0.0029	0.0172	0.0449
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0071	0.0071
Echinococcus multilocularis	cyclins	0.0119	0.1108	0.1108
Plasmodium vivax	cyclin dependent kinase binding protein, putative	0.0029	0.0172	0.1253
Echinococcus multilocularis	cyclin dependent kinase 1	0.0097	0.0874	0.0874
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0029	0.0172	0.0466
Echinococcus multilocularis	cyclin A3 4	0.0029	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0095	0.0258
Toxoplasma gondii	hypothetical protein	0.0091	0.0811	0.9206
Loa Loa (eye worm)	hypothetical protein	0.006	0.0496	0.1346
Echinococcus multilocularis	cyclins	0.0119	0.1108	0.1108
Trichomonas vaginalis	CMGC family protein kinase	0.0097	0.0874	0.3364
Echinococcus granulosus	cyclins	0.0119	0.1108	0.2895
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0029	0.0172	0.0466
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0029	0.0172	0.097
Trichomonas vaginalis	CMGC family protein kinase	0.0097	0.0874	0.3364
Echinococcus granulosus	muscleblind protein	0.018	0.1739	0.4543
Trichomonas vaginalis	cyclin D, putative	0.0119	0.1108	0.4486
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0119	0.1103	0.4466
Brugia malayi	Muscleblind-like protein	0.018	0.1739	0.4715
Brugia malayi	hypothetical protein	0.0029	0.0172	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0029	0.017	0.0461
Loa Loa (eye worm)	hypothetical protein	0.018	0.1739	0.4715
Echinococcus multilocularis	cyclin dependent kinase	0.0097	0.0874	0.0874
Echinococcus multilocularis	cyclin y	0.0029	0.0172	0.0172
Trypanosoma brucei	cyclin 9	0.0029	0.0172	0.046
Trypanosoma brucei	PAB1-binding protein , putative	0.0029	0.0174	0.0469
Schistosoma mansoni	g1/s-specific cyclin C	0.0029	0.0172	0.0449
Loa Loa (eye worm)	cyclin domain-containing protein	0.0029	0.0172	0.0466
Mycobacterium ulcerans	acyl-CoA synthetase	0.0029	0.017	1
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0097	0.0874	0.2371
Leishmania major	cyclin	0.0231	0.226	1
Loa Loa (eye worm)	hypothetical protein	0.0231	0.226	0.6127
Entamoeba histolytica	cyclin family protein	0.0119	0.1108	0.4491
Giardia lamblia	Cyclin A	0.0119	0.1108	0.4486
Schistosoma mansoni	serine/threonine protein kinase	0.0097	0.0874	0.2284
Loa Loa (eye worm)	hypothetical protein	0.018	0.1739	0.4715
Brugia malayi	Protein kinase domain containing protein	0.0097	0.0874	0.2371
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0029	0.017	1
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0029	0.0172	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0095	0.0258
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0496	0.1346
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0053	0.0418	0.1134
Echinococcus multilocularis	cyclin k	0.0029	0.0172	0.0172
Loa Loa (eye worm)	cyclin domain-containing protein	0.0029	0.0172	0.0466
Echinococcus multilocularis	isocitrate dehydrogenase	0.0019	0.0071	0.0071
Echinococcus multilocularis	cyclin B	0.0231	0.226	0.226
Toxoplasma gondii	hypothetical protein	0.0029	0.0172	0.1253
Schistosoma mansoni	hypothetical protein	0.0382	0.3829	1
Entamoeba histolytica	hypothetical protein	0.0043	0.0323	0.0733
Plasmodium falciparum	protein kinase 5	0.0097	0.0874	0.7743
Trypanosoma cruzi	cdc2-related kinase 1	0.0097	0.0874	0.367
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0071	0.0185
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0029	0.017	1
Trypanosoma cruzi	cdc2-related kinase 1	0.0097	0.0874	0.367
Echinococcus multilocularis	cyclins	0.0119	0.1108	0.1108
Echinococcus granulosus	Protein patched homolog 1	0.0051	0.0401	0.1048
Echinococcus multilocularis	muscleblind protein	0.018	0.1739	0.1739
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.002	0.0083	0.1199
Brugia malayi	hypothetical protein	0.0029	0.0174	0.0471
Trichomonas vaginalis	cyclins, putative	0.014	0.1323	0.5514
Brugia malayi	hypothetical protein	0.0019	0.0067	0.0183
Toxoplasma gondii	cyclin domain protein, cyclin H family protein	0.0029	0.0172	0.1253
Trypanosoma brucei	cyclin 3	0.0029	0.0172	0.046
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0029	0.0172	0.0466
Brugia malayi	hypothetical protein	0.0029	0.0172	0.0466
Echinococcus multilocularis	cyclin t1	0.0029	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0071	0.0192
Loa Loa (eye worm)	CYL-1 protein	0.0029	0.0172	0.0466
Plasmodium falciparum	cyclin dependent kinase binding protein, putative	0.0029	0.0172	0.097
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0029	0.017	0.5
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0019	0.0071	0.0071
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0029	0.017	1
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.0323	0.0844
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0095	0.0258
Plasmodium vivax	protein kinase Crk2	0.0097	0.0874	1
Leishmania major	hypothetical protein, conserved	0.0029	0.0174	0.0469
Loa Loa (eye worm)	cyclin domain-containing protein	0.0029	0.0172	0.0466
Brugia malayi	cyclin fold protein 1 variant b	0.0029	0.0172	0.0466
Echinococcus multilocularis	cyclin y	0.0029	0.0172	0.0172
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0029	0.0172	0.0466
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0019	0.0071	0.0193
Schistosoma mansoni	cyclin k	0.0029	0.0172	0.0449
Trypanosoma cruzi	cyclin 6, putative	0.0231	0.226	1
Brugia malayi	CHE-14 protein	0.0051	0.0401	0.1088
Echinococcus multilocularis	G1:S specific cyclin D1	0.0029	0.0172	0.0172
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0418	0.1093
Trypanosoma cruzi	cdc2-related kinase 3	0.0097	0.0874	0.367
Echinococcus multilocularis	cyclins	0.0119	0.1108	0.1108
Echinococcus granulosus	G1:S specific cyclin D1	0.0029	0.0172	0.0449
Echinococcus multilocularis	protein dispatched 1	0.0058	0.0476	0.0476
Trichomonas vaginalis	cyclin B, putative	0.0231	0.226	1
Echinococcus granulosus	cyclin G2	0.0029	0.0172	0.0449
Echinococcus granulosus	cyclin dependent kinase 5	0.0097	0.0874	0.2284
Trichomonas vaginalis	cyclin B, putative	0.0231	0.226	1
Entamoeba histolytica	cyclin family protein	0.0119	0.1108	0.4491
Trypanosoma cruzi	cdc2-related kinase 3	0.0097	0.0874	0.367
Echinococcus multilocularis	muscleblind protein 1	0.018	0.1739	0.1739
Schistosoma mansoni	hypothetical protein	0.0019	0.0071	0.0185
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0013	0.0008	0.0022
Giardia lamblia	G2/mitotic-specific cyclin B	0.0231	0.226	1
Echinococcus multilocularis	cdk5 and abl1 enzyme substrate 1	0.0029	0.0172	0.0172
Echinococcus granulosus	cdk5 and abl1 enzyme substrate 1	0.0029	0.0172	0.0449
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.0323	0.0323
Entamoeba histolytica	hypothetical protein	0.0043	0.0323	0.0733
Schistosoma mansoni	patched 1	0.0051	0.0401	0.1048
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1025	0.278
Echinococcus granulosus	Niemann Pick C1 protein	0.0119	0.1103	0.2882
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0174	0.099
Trypanosoma cruzi	cyclin, putative	0.0231	0.226	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0496	0.1346
Leishmania major	4-coumarate:coa ligase-like protein	0.0029	0.017	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0401	0.1088
Trypanosoma cruzi	mitotic cyclin, putative	0.0029	0.0172	0.046
Plasmodium vivax	ataxin-2 like protein, putative	0.0029	0.0174	0.1279
Onchocerca volvulus	Cyclin L homolog	0.0029	0.0172	0.076
Onchocerca volvulus		0.0029	0.017	0.0752
Trichomonas vaginalis	cyclins, putative	0.0231	0.226	1
Brugia malayi	AMP-binding enzyme family protein	0.0029	0.017	0.0461
Trichomonas vaginalis	conserved hypothetical protein	0.0051	0.0401	0.11
Echinococcus granulosus	geminin	0.0382	0.3829	1
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.0369	0.3688	0.3688
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0071	0.0192
Trypanosoma cruzi	hypothetical protein, conserved	0.0029	0.0172	0.046
Trypanosoma brucei	cdc2-related kinase 3	0.0097	0.0874	0.367
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0071	0.0071
Echinococcus granulosus	cyclin t1	0.0029	0.0172	0.0449
Echinococcus multilocularis	Niemann Pick C1 protein	0.017	0.1631	0.1631
Giardia lamblia	Kinase, CMGC CDK	0.0097	0.0874	0.3364
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0231	0.226	0.6127
Brugia malayi	N-terminal motif family protein	0.02	0.1938	0.5255
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0071	0.0071
Schistosoma mansoni	cyclin B	0.0231	0.226	0.5903
Echinococcus multilocularis	cyclin dependent kinase 1	0.0097	0.0874	0.0874
Echinococcus granulosus	Niemann Pick C1 protein	0.017	0.1631	0.426
Loa Loa (eye worm)	cyclin domain-containing protein	0.0029	0.0172	0.0466
Echinococcus granulosus	cyclin dependent kinase 1	0.0097	0.0874	0.2284
Echinococcus granulosus	cyclin b3	0.0119	0.1108	0.2895
Loa Loa (eye worm)	cyclin domain-containing protein	0.0029	0.0172	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0029	0.017	0.0461
Schistosoma mansoni	hypothetical protein	0.0043	0.0323	0.0844
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0097	0.0874	0.2371
Schistosoma mansoni	hypothetical protein	0.0019	0.0071	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0062	0.052	0.141
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0071	0.0192
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0097	0.0874	0.367
Toxoplasma gondii	cyclin dependent kinase binding protein	0.0029	0.0172	0.1253
Schistosoma mansoni	serine/threonine protein kinase	0.0097	0.0874	0.2284
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.002	0.0083	0.1199
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0029	0.017	1
Brugia malayi	hypothetical protein	0.0043	0.0323	0.0876
Schistosoma mansoni	hypothetical protein	0.0029	0.0172	0.0449
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.02	0.1938	0.5255
Echinococcus granulosus	cyclin A3 4	0.0029	0.0172	0.0449
Schistosoma mansoni	cyclin d	0.0029	0.0172	0.0449
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0019	0.0071	0.0186
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0496	0.1346
Trichomonas vaginalis	cyclin A, putative	0.0231	0.226	1
Brugia malayi	Cyclin C	0.0029	0.0172	0.0466
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0231	0.226	1
Echinococcus granulosus	Cyclin L1	0.0029	0.0172	0.0449
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0021	0.0095	0.2422
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.0418	0.0418
Plasmodium falciparum	cyclin 1	0.0029	0.0172	0.097
Entamoeba histolytica	cell division protein kinase 2, putative	0.0097	0.0874	0.337
Schistosoma mansoni	hypothetical protein	0.0041	0.0299	0.0782
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0071	0.0185
Echinococcus multilocularis	cyclins	0.0119	0.1108	0.1108
Trichomonas vaginalis	cyclin B, putative	0.0231	0.226	1
Schistosoma mansoni	hypothetical protein	0.0029	0.0172	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0174	0.0471
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0864	0.2342
Brugia malayi	Isocitrate dehydrogenase	0.0019	0.0071	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0299	0.0812
Echinococcus granulosus	oligomeric golgi complex subunit 3	0.0029	0.0172	0.0449
Leishmania major	4-coumarate:coa ligase-like protein	0.0029	0.017	0.0451
Echinococcus granulosus	cyclins	0.0029	0.0172	0.0449
Echinococcus granulosus	cyclin y	0.0029	0.0172	0.0449
Echinococcus granulosus	cyclin dependent kinase	0.0097	0.0874	0.2284
Echinococcus multilocularis	cyclin b3	0.0119	0.1108	0.1108
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0231	0.226	1
Echinococcus granulosus	cyclin B3 1	0.0119	0.1108	0.2895
Plasmodium vivax	cyclin 4, putative	0.0029	0.0172	0.1253
Leishmania major	cyclin 9, putative	0.0029	0.0172	0.046
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0019	0.0071	0.0186

Activities

Activity type	Activity value	Assay description	Source	Reference
CC50 (ADMET)	= 135 uM	Cytostatic activity against human Huh5-2 cells after 3 days by MTS method	ChEMBL.	23501114

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2375852

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1761982