Detailed view for EHI_159560

Basic information

TDR Targets ID: 805531
Entamoeba histolytica, cyclin C, putative
Source Database / ID:  AmoebaDB  

pI: 7.3252 | Length (AA): 255 | MW (Da): 29649 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00134   Cyclin, N-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016592   Srb-mediator complex  
GO:0016538   cyclin-dependent protein kinase regulator activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
7 253 5xs2 (B) 2 262 23.00 0 0.99 1.26993 -0.43
9 255 5xs2 (B) 4 254 27.00 0 0.99 1.26493 -0.48
24 253 1jkw (A) 48 279 20.00 0 1 1.08026 -0.08
61 209 5efq (B) 60 223 25.00 0.00014 0.9 0.836614 -0.23

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Trophozoite, Rahman HM-1 IMSS Trophozoite. Hon CC
Show/Hide expression data references
  • Hon CC Transcriptomics of virulent and avirulent strains

Orthologs

Ortholog group members (OG5_129826)

Species Accession Gene Product
Arabidopsis thaliana AT5G48640   cyclin-C1-1
Arabidopsis thaliana AT5G48630   cyclin-C1-2
Brugia malayi Bm1_15435   Cyclin C
Candida albicans CaO19.7355   RNA polymerase II holoenzyme cyclin-like subunit
Caenorhabditis elegans CELE_H14E04.5   Protein CIC-1
Dictyostelium discoideum DDB_G0274139   hypothetical protein
Drosophila melanogaster Dmel_CG7281   Cyclin C
Entamoeba histolytica EHI_159560   cyclin C, putative
Homo sapiens ENSG00000112237   cyclin C
Loa Loa (eye worm) LOAG_03129   cyclin C
Mus musculus ENSMUSG00000028252   cyclin C
Oryza sativa 9272663   Os09g0504400
Saccharomyces cerevisiae YNL025C   Ssn8p
Schistosoma japonicum Sjp_0302660   ko:K00960 DNA-directed RNA polymerase [EC2.7.7.6], putative
Schistosoma mansoni Smp_088250   g1/s-specific cyclin C
Schmidtea mediterranea mk4.000373.12   CyclinC-like protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens cyclin C Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0751 0.3733 1
0.0867 0.2761 1
0.0122 0.3541 1
0.0105 0.4899 1
0.0124 0.4799 0.5
0.118 0.4264 0.5
0.1205 0.2908 1
0.0435 0.4996 1
0.0411 0.4082 1
0.0751 0.3733 1
0.0908 0.3003 1
0.0839 0.2867 1
0.0734 0.2775 1
0.118 0.4264 0.5
0.04 0.2659 1
0.0328 0.4993 1
0.0768 0.2732 1
0.064 0.4983 1
0.0318 0.498 1
0.0980999 0.395232 1
0.0755 0.3051 1
0.0747 0.2742 1
0.012 0.256 0.5
0.0624 0.3372 1
0.0549507 0.474538 1
0.117 0.4299 0.5
0.0212 0.4625 1
0.0314 0.4986 1
0.0547 0.4978 1
0.0898 0.2996 1
0.0803 0.5009 1
0.0875 0.353 1
0.0124 0.4799 0.5
0.0658 0.4986 1
0.0980999 0.395232 1
0.056 0.498 1
0.0793 0.4972 1
0.0898 0.2996 1
0.0799 0.4978 1
0.0106 0.4451 1
0.0232 0.4042 1
0.0980999 0.395232 1
0.0103 0.3608 1
0.01 0.4683 1
0.1321 0.4321 0.5
0.1343 0.5013 0.5
0.0434 0.4983 1
0.0102 0.3595 1
0.0867 0.2761 1
0.1306 0.4979 0.5
0.0124 0.4899 1
0.0888 0.3169 1
0.012 0.256 0.5
0.0566 0.4112 0.5
0.0124 0.4799 0.5
0.1205 0.2908 1
0.0803 0.5009 1
0.0124 0.3875 1
0.0867 0.2761 1
0.0429 0.4996 1
0.0124 0.4799 0.5
0.0321 0.2828 1
0.0124 0.4799 0.5
0.0628 0.4984 1
0.0888 0.3169 1
0.0867 0.2761 1
0.0132 0.4086 1
0.0323 0.4979 1
0.0206 0.5004 1
0.0347 0.4023 1
0.0556 0.4949 1
0.0406 0.4885 0.5
0.0211 0.2688 1
0.0205 0.2651 1
0.0328 0.4993 1
0.0108 0.3762 0.5
0.0547 0.4978 1
0.0556 0.3357 1
0.0898 0.2782 1
0.0238 0.4678 0.5
0.055 0.3257 0.5
0.0793 0.4972 1
0.0317 0.4984 1
0.0323 0.4953 0.5
0.0434 0.4983 1
0.0722 0.2551 1
0.0888 0.3169 1
0.0223 0.4944 1
0.0202 0.2604 1
0.0112 0.4471 1
0.0323 0.4979 1
0.1321 0.4321 0.5
0.0735 0.4825 1
0.012 0.4324 1
0.0206 0.5004 1
0.0648 0.2697 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier EHI_159560 (Entamoeba histolytica), cyclin C, putative
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