Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | STE group serine/threonine-protein kinase, putative | 0.0046 | 0.001 | 0.0388 |
Trypanosoma cruzi | STE/STE20 serine/threonine-protein kinase, putative | 0.0058 | 0.0249 | 1 |
Trypanosoma brucei | STE20-like serine/threonine-protein kinase 1, putative | 0.0058 | 0.0249 | 0.5 |
Onchocerca volvulus | 0.0128 | 0.1552 | 1 | |
Leishmania major | protein kinase, putative | 0.0046 | 0.001 | 0.0388 |
Echinococcus multilocularis | myosin iiia | 0.0058 | 0.0249 | 0.0648 |
Mycobacterium ulcerans | putative regulatory protein | 0.0128 | 0.1552 | 0.5 |
Loa Loa (eye worm) | TKL/LRRK protein kinase | 0.0066 | 0.0388 | 0.0388 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0046 | 0.001 | 0.0388 |
Echinococcus multilocularis | serine:threonine protein kinase 3 | 0.0251 | 0.3843 | 1 |
Entamoeba histolytica | serine/threonine-protein kinase 3, putative | 0.0058 | 0.0249 | 0.5 |
Mycobacterium leprae | Possible regulatory protein | 0.0045 | 0 | 0.5 |
Chlamydia trachomatis | two component regulatory system sensor histidine kinase | 0.0045 | 0 | 0.5 |
Brugia malayi | bHLH-PAS transcription factor | 0.0128 | 0.1552 | 0.121 |
Brugia malayi | hypoxia-induced factor 1 | 0.0537 | 0.916 | 0.9126 |
Schistosoma mansoni | ste20-related kinase | 0.0194 | 0.2764 | 1 |
Loa Loa (eye worm) | STE/STE20/MST protein kinase | 0.0251 | 0.3843 | 0.3843 |
Echinococcus granulosus | serine:threonine protein kinase 3 | 0.0251 | 0.3843 | 1 |
Echinococcus granulosus | leucine rich repeat serine:threonine protein | 0.0066 | 0.0397 | 0.1032 |
Trypanosoma cruzi | STE group serine/threonine-protein kinase, putative | 0.0046 | 0.001 | 0.0388 |
Echinococcus multilocularis | leucine rich repeat serine:threonine protein | 0.0066 | 0.0388 | 0.1011 |
Brugia malayi | PAS domain containing protein | 0.0173 | 0.2391 | 0.2084 |
Echinococcus granulosus | single minded 2 | 0.0128 | 0.1552 | 0.4037 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0128 | 0.1552 | 0.4037 |
Giardia lamblia | Kinase, STE STE20 | 0.0058 | 0.0249 | 0.5 |
Trypanosoma cruzi | STE/STE20 serine/threonine-protein kinase, putative | 0.0058 | 0.0249 | 1 |
Brugia malayi | STE20-like kinase MST | 0.0251 | 0.3843 | 0.3594 |
Entamoeba histolytica | serine/threonine protein kinase STE20, putative | 0.0058 | 0.0249 | 0.5 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0537 | 0.916 | 0.916 |
Trichomonas vaginalis | STE family protein kinase | 0.0058 | 0.0249 | 1 |
Leishmania major | protein kinase, putative | 0.0058 | 0.0249 | 1 |
Leishmania major | protein kinase, putative | 0.0046 | 0.001 | 0.0388 |
Loa Loa (eye worm) | hypothetical protein | 0.0582 | 1 | 1 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0046 | 0.001 | 0.0388 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.