Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Peroxidasin homolog | 0.007 | 0.2517 | 1 |
Schistosoma mansoni | peroxidasin | 0.007 | 0.2517 | 0.3565 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0064 | 0.2243 | 0.3176 |
Echinococcus multilocularis | peroxidasin | 0.007 | 0.2517 | 0.3565 |
Echinococcus granulosus | geminin | 0.0177 | 0.706 | 1 |
Onchocerca volvulus | 0.007 | 0.2517 | 1 | |
Brugia malayi | Animal haem peroxidase family protein | 0.007 | 0.2517 | 0.2517 |
Brugia malayi | Peroxidasin | 0.007 | 0.2517 | 0.2517 |
Onchocerca volvulus | 0.007 | 0.2517 | 1 | |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 0.2243 | 0.3176 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.007 | 0.2517 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0064 | 0.2243 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.007 | 0.2517 | 0.2517 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.2517 | 0.2517 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.2243 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.007 | 0.2517 | 0.2517 |
Brugia malayi | Animal haem peroxidase family protein | 0.007 | 0.2517 | 0.2517 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.2517 | 0.2517 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.2517 | 0.2517 |
Loa Loa (eye worm) | animal heme peroxidase | 0.007 | 0.2517 | 0.2517 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0014 | 0.0155 | 0.5 |
Loa Loa (eye worm) | POT family protein | 0.0124 | 0.48 | 0.48 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.2517 | 0.2517 |
Onchocerca volvulus | 0.007 | 0.2517 | 1 | |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0064 | 0.2243 | 0.3176 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.2517 | 0.2517 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0247 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.2517 | 0.2517 |
Brugia malayi | Animal haem peroxidase family protein | 0.007 | 0.2517 | 0.2517 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 0.2243 | 0.3176 |
Onchocerca volvulus | Peroxidase homolog | 0.007 | 0.2517 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.007 | 0.2517 | 0.2517 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.2517 | 0.2517 |
Onchocerca volvulus | Peroxidase homolog | 0.007 | 0.2517 | 1 |
Echinococcus multilocularis | geminin | 0.0177 | 0.706 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.706 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.007 | 0.2517 | 0.2517 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.2517 | 0.2517 |
Onchocerca volvulus | Peroxidasin homolog | 0.007 | 0.2517 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.706 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.007 | 0.2517 | 0.2517 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.2517 | 0.2517 |
Schistosoma mansoni | peroxidasin | 0.007 | 0.2517 | 0.3565 |
Brugia malayi | POT family protein | 0.0124 | 0.48 | 0.48 |
Brugia malayi | hypothetical protein | 0.007 | 0.2517 | 0.2517 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.2517 | 0.2517 |
Brugia malayi | Animal haem peroxidase family protein | 0.007 | 0.2517 | 0.2517 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.2517 | 0.2517 |
Onchocerca volvulus | Dual oxidase homolog | 0.007 | 0.2517 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.2243 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.2517 | 0.2517 |
Loa Loa (eye worm) | animal heme peroxidase | 0.007 | 0.2517 | 0.2517 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0064 | 0.2243 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.007 | 0.2517 | 0.3565 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.2517 | 0.2517 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.2517 | 0.2517 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0064 | 0.2243 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0014 | 0.0155 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.2243 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Log 1/C (functional) | = 5.14 | Tested for 50% protection of MT-4 cells from HIV infection | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.