Detailed view for LOAG_04195

Basic information

TDR Targets ID: 946511
Loa Loa (eye worm), POT family protein
Source Database / ID:  KEGG  

pI: 6.5501 | Length (AA): 673 | MW (Da): 74728 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 11

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00854   POT family

Gene Ontology

Mouse over links to read term descriptions.
GO:1902600   GO:proton transmembrane transport  

GO:0071916   GO:dipeptide transmembrane transporter activity  

GO:0042938   dipeptide transport  
GO:0022857   transmembrane transporter activity  
GO:0015252   hydrogen ion channel activity  
GO:0016020   membrane  
GO:0005215   transporter activity  
GO:0055085   transmembrane transport  
GO:0006857   oligopeptide transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
15 372 4uvm (A) 10 395 39.00 0 1 0.715246 0.98
16 394 6ei3 (A) 16 425 38.00 0 0.96 0.74945 0.71
237 292 3tqt (A) 2 55 43.00 0.59 0.07 0.33351 1.48

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126717)

Species Accession Gene Product
Arabidopsis thaliana AT1G72140   putative peptide/nitrate transporter
Arabidopsis thaliana AT1G22570   putative peptide/nitrate transporter
Arabidopsis thaliana AT3G53960   probable peptide/nitrate transporter
Arabidopsis thaliana AT1G72125   putative peptide/nitrate transporter
Arabidopsis thaliana AT1G22550   putative peptide/nitrate transporter
Arabidopsis thaliana AT1G72120   putative peptide/nitrate transporter
Arabidopsis thaliana AT1G72130   putative peptide/nitrate transporter
Arabidopsis thaliana AT2G02040   peptide transporter PTR2
Arabidopsis thaliana AT3G54140   peptide transporter PTR1
Arabidopsis thaliana AT2G37900   putative peptide/nitrate transporter
Arabidopsis thaliana AT2G02020   peptide transporter 4
Arabidopsis thaliana AT1G62200   putative peptide/nitrate transporter
Arabidopsis thaliana AT5G01180   peptide transporter PTR5
Arabidopsis thaliana AT1G22540   probable peptide/nitrate transporter
Brugia malayi Bm1_47870   POT family protein
Candida albicans CaO19.6937   second version of peptide transport protein more similar to S. cerevisiae PTR2
Candida albicans CaO19.14199   second version of peptide transport protein more similar to S. cerevisiae PTR2
Caenorhabditis elegans CELE_F56F4.5   Protein PEPT-3
Caenorhabditis elegans CELE_C06G8.2   Protein PEPT-2
Caenorhabditis elegans CELE_K04E7.2   Protein PEPT-1
Dictyostelium discoideum DDB_G0272550   hypothetical protein
Dictyostelium discoideum DDB_G0267874   hypothetical protein
Dictyostelium discoideum DDB_G0272468   hypothetical protein
Drosophila melanogaster Dmel_CG2930   CG2930 gene product from transcript CG2930-RF
Drosophila melanogaster Dmel_CG44402   CG44402 gene product from transcript CG44402-RD
Escherichia coli b3496   dipeptide and tripeptide permease B
Escherichia coli b0709   dipeptide and tripeptide permease D
Escherichia coli b1634   dipeptide and tripeptide permease A
Homo sapiens ENSG00000088386   solute carrier family 15 (oligopeptide transporter), member 1
Homo sapiens ENSG00000163406   solute carrier family 15 (oligopeptide transporter), member 2
Homo sapiens ENSG00000139370   solute carrier family 15 (oligopeptide transporter), member 4
Loa Loa (eye worm) LOAG_04195   POT family protein
Mus musculus ENSMUSG00000025557   solute carrier family 15 (oligopeptide transporter), member 1
Mus musculus ENSMUSG00000022899   solute carrier family 15 (H+/peptide transporter), member 2
Mus musculus ENSMUSG00000029416   solute carrier family 15, member 4
Oryza sativa 4324943   Os01g0871500
Oryza sativa 9268299   Os01g0386600
Oryza sativa 4332183   Os03g0235900
Oryza sativa 4333931   Os03g0719900
Oryza sativa 4324944   Os01g0871600
Oryza sativa 4342165   Os07g0100600
Oryza sativa 4325456   Os01g0142800
Oryza sativa 4332182   Os03g0235700
Oryza sativa 4334618   Os03g0823500
Oryza sativa 4325015   Os01g0902800
Oryza sativa 4347968   Os10g0111300
Oryza sativa 4325014   Os01g0902700
Oryza sativa 4332178   Os03g0235300
Saccharomyces cerevisiae YKR093W   Ptr2p
Schmidtea mediterranea mk4.006926.00  
Schmidtea mediterranea mk4.001091.06  
Schmidtea mediterranea mk4.009754.00   Solute carrier family 15 member 5
Schmidtea mediterranea mk4.000778.00  
Schmidtea mediterranea mk4.003908.00  
Schmidtea mediterranea mk4.007063.01  
Schmidtea mediterranea mk4.004437.01  
Schmidtea mediterranea mk4.000778.02  
Schmidtea mediterranea mk4.002936.01  
Schmidtea mediterranea mk4.000778.01  
Schmidtea mediterranea mk4.090268.00  
Schmidtea mediterranea mk4.024637.00   Solute carrier family 15 member 5

Essentiality

LOAG_04195 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b0709 Escherichia coli non-essential goodall
b1634 Escherichia coli non-essential goodall
b3496 Escherichia coli non-essential goodall
CELE_K04E7.2 Caenorhabditis elegans larval arrest wormbase
CELE_K04E7.2 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus Oligopeptide transporter, kidney isoform Compounds References
Homo sapiens solute carrier family 15 (oligopeptide transporter), member 2 Compounds References
Homo sapiens solute carrier family 15 (oligopeptide transporter), member 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0199 0.2755 0.2577
0.0164 0.2563 0.6391
0.0204 0.2611 0.3267
0.0088 0.2863 0.2863
0.0263 0.3092 0.423
0.0129 1 1
0.0084 0.3111 0.3111
0.0085 0.5 0.5
0.021 0.2916 0.6803
0.0083 0.283 0.283
0.0082 0.274 0.241
0.0124 0.48 0.48
0.0047 0.3124 0.3124
0.0079 0.2611 0.3905
0.0079 0.7304 0.7304
0.0126 0.3463 0.5072
0.0308 0.4395 0.39
0.0216 0.3182 0.5219
0.0085 0.2855 0.2855
0.0079 0.2611 0.3905
0.0039 0.3281 0
0.0252 0.3068 0.2396
0.0123 1 1
0.0202 0.2753 0.4541
0.0216 0.3182 0.5219
0.0202 0.2753 0.4541
0.0125 0.5 0.5
0.008 1 1
0.0218 0.8014 0.8014
0.0085 0.2955 0.286
0.0085 0.5 0.5
0.0088 0.5 0.5
0.0308 0.3637 0.47
0.0179 0.6194 0.4618
0.0124 0.5188 0.5153
0.0216 0.3182 0.5219
0.0049 0.3148 0.2936
0.0049 0.3148 0.2936
0.0099 0.5 0.5
0.0207 1 1
0.008 0.2747 0.2736
0.004 0.4276 0.7415
0.0169 0.7418 0.7418
0.0039 0.3281 0
0.0254 0.3723 0.3723
0.0168 0.5873 0.5873
0.0119 1 1
0.0201 0.3273 0.3248

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier LOAG_04195 (Loa Loa (eye worm)), POT family protein
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