Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0304 | 0.3013 | 0.5109 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0252 | 0.1958 | 0.5 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.032 | 0.3354 | 0.4282 |
Plasmodium falciparum | phd finger protein, putative | 0.0157 | 0 | 0.5 |
Giardia lamblia | PHD finger protein 15 | 0.0157 | 0 | 0.5 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0445 | 0.5898 | 0.5898 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.032 | 0.3354 | 0.5687 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0252 | 0.1958 | 0.1958 |
Echinococcus granulosus | jumonji domain containing protein | 0.0218 | 0.1261 | 0.1261 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0218 | 0.1261 | 0.1261 |
Echinococcus multilocularis | neuropeptide receptor | 0.0533 | 0.7722 | 0.7722 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.032 | 0.3354 | 0.4282 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.032 | 0.3354 | 0.3354 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0533 | 0.7722 | 0.7722 |
Onchocerca volvulus | Alhambra homolog | 0.0157 | 0 | 0.5 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0157 | 0 | 0.5 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0252 | 0.1958 | 0.1958 |
Plasmodium vivax | hypothetical protein, conserved | 0.0157 | 0 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0324 | 0.3427 | 0.5811 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0252 | 0.1958 | 0.5 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.032 | 0.3354 | 0.3354 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0252 | 0.1958 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 0.5898 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0645 | 1 | 1 |
Brugia malayi | jmjC domain containing protein | 0.032 | 0.3354 | 0.3354 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0157 | 0 | 0.5 |
Schistosoma mansoni | jumonji domain containing protein | 0.0539 | 0.7833 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0645 | 1 | 1 |
Schistosoma mansoni | neuropeptide receptor | 0.0533 | 0.7722 | 0.9858 |
Echinococcus granulosus | neuropeptide receptor | 0.0533 | 0.7722 | 0.7722 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.823 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.813 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.76 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.737 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.736 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.733 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.664 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.