Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | MAP kinase sur-1 | 0.3493 | 0.619 | 0.6424 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0422 | 0.0374 | 0.0374 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.3493 | 0.619 | 0.619 |
Schistosoma mansoni | serine/threonine protein kinase | 0.5504 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.3493 | 0.619 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0422 | 0.0374 | 0.0376 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.3493 | 0.619 | 0.619 |
Trypanosoma brucei | protein kinase, putative | 0.3493 | 0.619 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0422 | 0.0374 | 0.0374 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.3493 | 0.619 | 0.619 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0422 | 0.0374 | 0.0374 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.3493 | 0.619 | 0.6222 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0422 | 0.0374 | 0.0374 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0422 | 0.0374 | 0.0374 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.3493 | 0.619 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.3493 | 0.619 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.3493 | 0.619 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.3493 | 0.619 | 0.5 |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.5504 | 1 | 1 |
Loa Loa (eye worm) | raf kinase | 0.5477 | 0.9949 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.3493 | 0.619 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.3493 | 0.619 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0422 | 0.0374 | 0.0374 |
Trichomonas vaginalis | CMGC family protein kinase | 0.3493 | 0.619 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.3493 | 0.619 | 1 |
Brugia malayi | P38 map kinase family protein 2 | 0.0422 | 0.0374 | 0.0388 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.3493 | 0.619 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.3493 | 0.619 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.3493 | 0.619 | 0.619 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.3493 | 0.619 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.3493 | 0.619 | 0.619 |
Brugia malayi | Raf kinase | 0.5312 | 0.9636 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.3493 | 0.619 | 0.5 |
Loa Loa (eye worm) | TKL/RAF/RAF protein kinase | 0.312 | 0.5485 | 0.5513 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Inhibition of human BuChE using butyrylthiocholine iodide as substrate incubated for 20 mins prior to substrate addition measured for 1 hr by Ellman's method | ChEMBL. | 23719283 |
IC50 (binding) | > 100 uM | Inhibition of human AchE using acetylthiocholine iodide as substrate incubated for 20 mins prior to substrate addition measured for 1 hr by Ellman's method | ChEMBL. | 23719283 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.