Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | adam (A disintegrin and metalloprotease | 0.0121 | 0.1544 | 0.3388 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0092 | 0.0792 | 0.1307 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0192 | 0.3375 | 0.7338 |
Brugia malayi | ADAM-TS Spacer 1 family protein | 0.0253 | 0.4939 | 1 |
Brugia malayi | hypothetical protein | 0.0121 | 0.1544 | 0.3126 |
Echinococcus granulosus | adam 17 protease | 0.0235 | 0.4484 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0224 | 0.0224 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 0.4939 | 0.4939 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0319 | 0.0319 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0214 | 0.3935 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.0995 | 0.0995 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0134 | 0.1884 | 0.3756 |
Echinococcus multilocularis | adam | 0.0121 | 0.1544 | 0.3388 |
Brugia malayi | ADAMTS-like protease | 0.0107 | 0.1194 | 0.2417 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0134 | 0.1884 | 0.4327 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0092 | 0.0792 | 0.1135 |
Onchocerca volvulus | Papilin homolog | 0.007 | 0.0224 | 0.5 |
Brugia malayi | metalloprotease disintegrin 16 with thrombospondin type I motif | 0.0101 | 0.1029 | 0.2082 |
Echinococcus granulosus | adam | 0.0121 | 0.1544 | 0.2941 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0192 | 0.3375 | 0.8453 |
Loa Loa (eye worm) | reprolysin | 0.0073 | 0.0319 | 0.0319 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0192 | 0.3375 | 0.8453 |
Echinococcus multilocularis | adam 17 protease | 0.0214 | 0.3935 | 1 |
Brugia malayi | angiogenesis inhibito | 0.0107 | 0.1194 | 0.2417 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | > 150 uM | Agonist activity at GST-tagged human FXR LBD assessed as recruitment of biotinylated SRC-1 peptide after 30 mins by AlphaScreen assay | ChEMBL. | 23684233 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.