Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | adenosine A2a receptor | 412 aa | 336 aa | 22.3 % |
Brugia malayi | hypothetical protein | adenosine A1 receptor | 326 aa | 305 aa | 21.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0429 | 1 | 1 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0253 | 0.2852 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0421 | 0.9706 | 0.9706 |
Giardia lamblia | Hypothetical protein | 0.0253 | 0.2852 | 0.5 |
Onchocerca volvulus | 0.0429 | 1 | 0.5 | |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0429 | 1 | 1 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0429 | 1 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0421 | 0.9706 | 0.9706 |
Loa Loa (eye worm) | hypothetical protein | 0.0421 | 0.9706 | 0.9604 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.0429 | 1 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0429 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0429 | 1 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0429 | 1 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.0421 | 0.9706 | 0.9706 |
Giardia lamblia | Hypothetical protein | 0.0253 | 0.2852 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0421 | 0.9706 | 0.9706 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0253 | 0.2852 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0253 | 0.2852 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antiparkinsonian activity in mouse assessed as reversal of haloperidol-induced catalepsy at 3 mg/kg, po after 1 hr | ChEMBL. | 23522563 | |
Ki (functional) | = 4.7 nM | Antagonist activity at human adenosine A2a receptor expressed in CHOK1 cells assessed as inhibition of NECA/forskolin-induced cAMP accumulation incubated for 15 mins prior to NECA/forskolin challenge measured after 5.5 to 6 hrs by beta-galactosidase reporter gene assay | ChEMBL. | 23522563 |
Ki (functional) | = 310 nM | Antagonist activity at human adenosine A1 receptor expressed in CHOK1 cells assessed as inhibition of R-PIA/forskolin-induced cAMP accumulation incubated for 15 mins prior to R-PIA/forskolin challenge measured after 5.5 to 6 hrs by beta-galactosidase reporter gene assay | ChEMBL. | 23522563 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.