Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0582 | 1 | 1 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0046 | 0.001 | 0.0388 |
Entamoeba histolytica | serine/threonine protein kinase STE20, putative | 0.0058 | 0.0249 | 0.5 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0537 | 0.916 | 0.916 |
Trichomonas vaginalis | STE family protein kinase | 0.0058 | 0.0249 | 1 |
Leishmania major | protein kinase, putative | 0.0046 | 0.001 | 0.0388 |
Leishmania major | protein kinase, putative | 0.0058 | 0.0249 | 1 |
Brugia malayi | STE20-like kinase MST | 0.0251 | 0.3843 | 0.3594 |
Giardia lamblia | Kinase, STE STE20 | 0.0058 | 0.0249 | 0.5 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0128 | 0.1552 | 0.4037 |
Trypanosoma cruzi | STE/STE20 serine/threonine-protein kinase, putative | 0.0058 | 0.0249 | 1 |
Brugia malayi | PAS domain containing protein | 0.0173 | 0.2391 | 0.2084 |
Echinococcus multilocularis | leucine rich repeat serine:threonine protein | 0.0066 | 0.0388 | 0.1011 |
Echinococcus granulosus | single minded 2 | 0.0128 | 0.1552 | 0.4037 |
Echinococcus granulosus | leucine rich repeat serine:threonine protein | 0.0066 | 0.0397 | 0.1032 |
Trypanosoma cruzi | STE group serine/threonine-protein kinase, putative | 0.0046 | 0.001 | 0.0388 |
Brugia malayi | hypoxia-induced factor 1 | 0.0537 | 0.916 | 0.9126 |
Schistosoma mansoni | ste20-related kinase | 0.0194 | 0.2764 | 1 |
Echinococcus granulosus | serine:threonine protein kinase 3 | 0.0251 | 0.3843 | 1 |
Loa Loa (eye worm) | STE/STE20/MST protein kinase | 0.0251 | 0.3843 | 0.3843 |
Chlamydia trachomatis | two component regulatory system sensor histidine kinase | 0.0045 | 0 | 0.5 |
Brugia malayi | bHLH-PAS transcription factor | 0.0128 | 0.1552 | 0.121 |
Mycobacterium leprae | Possible regulatory protein | 0.0045 | 0 | 0.5 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0046 | 0.001 | 0.0388 |
Loa Loa (eye worm) | TKL/LRRK protein kinase | 0.0066 | 0.0388 | 0.0388 |
Echinococcus multilocularis | serine:threonine protein kinase 3 | 0.0251 | 0.3843 | 1 |
Entamoeba histolytica | serine/threonine-protein kinase 3, putative | 0.0058 | 0.0249 | 0.5 |
Echinococcus multilocularis | myosin iiia | 0.0058 | 0.0249 | 0.0648 |
Mycobacterium ulcerans | putative regulatory protein | 0.0128 | 0.1552 | 0.5 |
Onchocerca volvulus | 0.0128 | 0.1552 | 1 | |
Leishmania major | protein kinase, putative | 0.0046 | 0.001 | 0.0388 |
Trypanosoma brucei | STE20-like serine/threonine-protein kinase 1, putative | 0.0058 | 0.0249 | 0.5 |
Trypanosoma cruzi | STE/STE20 serine/threonine-protein kinase, putative | 0.0058 | 0.0249 | 1 |
Trypanosoma cruzi | STE group serine/threonine-protein kinase, putative | 0.0046 | 0.001 | 0.0388 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.