Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0032 | 0.3035 | 0.1843 |
Schistosoma mansoni | plexin | 0.0034 | 0.3295 | 0.4141 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1462 | 0.0354 |
Plasmodium vivax | pyruvate kinase, putative | 0.0032 | 0.3035 | 1 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0032 | 0.3035 | 0.5 |
Plasmodium falciparum | pyruvate kinase | 0.0032 | 0.3035 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.0032 | 0.3035 | 0.3814 |
Chlamydia trachomatis | pyruvate kinase | 0.0032 | 0.3035 | 0.5 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0024 | 0.1462 | 0.0354 |
Leishmania major | pyruvate kinase | 0.0032 | 0.3035 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.7957 | 0.7692 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.1462 | 0.1837 |
Schistosoma mansoni | pyruvate kinase | 0.0032 | 0.3035 | 0.3814 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1462 | 0.0354 |
Echinococcus granulosus | semaphorin 1A | 0.0024 | 0.1462 | 0.1462 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0032 | 0.3035 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.0026 | 0.1721 | 0.1721 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0032 | 0.3035 | 0.2422 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.1462 | 0.1837 |
Echinococcus multilocularis | semaphorin 5B | 0.0024 | 0.1462 | 0.1462 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1462 | 0.0354 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.3035 | 0.2132 |
Loa Loa (eye worm) | pyruvate kinase | 0.0032 | 0.3035 | 0.2132 |
Echinococcus granulosus | semaphorin 5B | 0.0024 | 0.1462 | 0.1462 |
Mycobacterium ulcerans | pyruvate kinase | 0.0032 | 0.3035 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.0032 | 0.3035 | 0.2132 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1462 | 0.0354 |
Echinococcus multilocularis | pyruvate kinase | 0.0032 | 0.3035 | 0.3035 |
Loa Loa (eye worm) | pyruvate kinase | 0.0032 | 0.3035 | 0.2132 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1462 | 0.0354 |
Brugia malayi | Plexin repeat family protein | 0.0058 | 0.7957 | 0.7608 |
Echinococcus multilocularis | hypothetical protein | 0.0024 | 0.1462 | 0.1462 |
Onchocerca volvulus | 0.0058 | 0.7957 | 1 | |
Loa Loa (eye worm) | plexin A | 0.0068 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.3295 | 0.2425 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0032 | 0.3035 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.3295 | 0.4141 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0032 | 0.3035 | 0.5 |
Schistosoma mansoni | semaphorin 5-related | 0.0024 | 0.1462 | 0.1837 |
Leishmania major | pyruvate kinase | 0.0032 | 0.3035 | 0.5 |
Echinococcus granulosus | pyruvate kinase | 0.0032 | 0.3035 | 0.3035 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1462 | 0.0354 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0023 | 0.1148 | 0.5 |
Echinococcus granulosus | pyruvate kinase | 0.0032 | 0.3035 | 0.3035 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0032 | 0.3035 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.0032 | 0.3035 | 0.3035 |
Giardia lamblia | Pyruvate kinase | 0.0032 | 0.3035 | 1 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0032 | 0.3035 | 0.5 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0024 | 0.1462 | 0.0354 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0032 | 0.3035 | 0.2422 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0032 | 0.3035 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0032 | 0.3035 | 0.2422 |
Schistosoma mansoni | plexin | 0.0058 | 0.7957 | 1 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0032 | 0.3035 | 0.5 |
Echinococcus granulosus | plexin a4 | 0.0068 | 1 | 1 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0032 | 0.3035 | 0.1843 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0032 | 0.3035 | 0.5 |
Echinococcus multilocularis | plexin a4 | 0.0068 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.