Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | aurora kinase B | Starlite/ChEMBL | References |
Homo sapiens | aurora kinase A | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | aurora kinase B | 303 aa | 299 aa | 22.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.1147 | 0.3894 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2698 | 1 | 1 |
Brugia malayi | Casein kinase II, alpha chain | 0.1147 | 0.3894 | 0.3894 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.1147 | 0.3894 | 0.3894 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.1147 | 0.3894 | 1 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.2698 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1147 | 0.3894 | 1 |
Plasmodium vivax | unspecified product | 0.1147 | 0.3894 | 1 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.1147 | 0.3894 | 1 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.1147 | 0.3894 | 0.3894 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1147 | 0.3894 | 1 |
Leishmania major | casein kinase II, putative | 0.1147 | 0.3894 | 1 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.2698 | 1 | 1 |
Giardia lamblia | Kinase, CMGC CK2 | 0.1147 | 0.3894 | 1 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.2698 | 1 | 1 |
Schistosoma mansoni | protein kinase | 0.1147 | 0.3894 | 0.3894 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1147 | 0.3894 | 1 |
Trypanosoma brucei | Casein kinase II | 0.1147 | 0.3894 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.1147 | 0.3894 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1147 | 0.3894 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1147 | 0.3894 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1147 | 0.3894 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1147 | 0.3894 | 1 |
Entamoeba histolytica | casein kinase, putative | 0.1147 | 0.3894 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/PASK protein kinase | 0.0925 | 0.302 | 0.302 |
Trypanosoma cruzi | casein kinase II, putative | 0.1147 | 0.3894 | 1 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.2698 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.1147 | 0.3894 | 0.3894 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.2698 | 1 | 1 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.2698 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2 nM | Inhibition of aurora-B (unknown origin) | ChEMBL. | 23570792 |
IC50 (binding) | = 3 nM | Inhibition of aurora-A (unknown origin) | ChEMBL. | 23570792 |
IC50 (functional) | = 2390 nM | Antiproliferative activity against human MIAPaCa2 cells | ChEMBL. | 23570792 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 23570792 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.