TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 424.426 | Formula: C25H17FN4O2
H donors: 3 H acceptors: 3 LogP: 4.2 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(cc1)C(=O)Nc1ccc(cc1)Nc1ccnc2c1c1ccccc1c(=O)[nH]2
InChi: 1S/C25H17FN4O2/c26-16-7-5-15(6-8-16)24(31)29-18-11-9-17(10-12-18)28-21-13-14-27-23-22(21)19-3-1-2-4-20(19)25(32)30-23/h1-14H,(H,29,31)(H2,27,28,30,32)
InChiKey: GZEGBHAXGLPTQY-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	aurora kinase A	Starlite/ChEMBL	References
Homo sapiens	aurora kinase B	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania major	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania braziliensis	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium berghei	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania mexicana	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	serine:threonine protein kinase 12 B	Get druggable targets OG5_127024	All targets in OG5_127024
Candida albicans	likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine kinase 12	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma brucei gambiense	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania infantum	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine protein kinase 6	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania donovani	Aurora I-related kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium yoelii	putative protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	serine:threonine protein kinase 12 B	Get druggable targets OG5_127024	All targets in OG5_127024
Toxoplasma gondii	aurora kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Cryptosporidium hominis	protein kinase (EC 2.7.1.-) p46XlEg22	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase , putative	Get druggable targets OG5_127024	All targets in OG5_127024
Giardia lamblia	Aurora kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine-protein kinase 6	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	aurora kinase A	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma congolense	aurora B kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium vivax	serine/threonine protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Cryptosporidium parvum	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma cruzi	aurora B kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	serine/threonine protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium falciparum	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_127024	All targets in OG5_127024
Candida albicans	likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu	Get druggable targets OG5_127024	All targets in OG5_127024
Neospora caninum	hypothetical protein	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium yoelii	Protein kinase domain, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma brucei	aurora B kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	Serine/threonine-protein kinase 12, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium knowlesi	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	aurora kinase A	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	ko:K08850 aurora kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	aurora kinase B	303 aa	299 aa	22.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.033	0.9943	0.9943
Brugia malayi	SH2 domain containing protein	0.033	0.9943	1
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0203	0.3422	0.3422
Loa Loa (eye worm)	hypothetical protein	0.0203	0.3422	0.3441
Schistosoma mansoni	shc transforming protein	0.0203	0.3422	0.3441
Loa Loa (eye worm)	hypothetical protein	0.0203	0.3422	0.3441
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0203	0.3422	0.3441
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0203	0.3422	0.3441
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.033	0.9943	1
Schistosoma mansoni	SH2A	0.0203	0.3422	0.3441
Schistosoma mansoni	suppressor of cytokine signaling	0.0203	0.3422	0.3441
Brugia malayi	SH2 domain containing protein	0.0203	0.3422	0.3441
Brugia malayi	RhoGAP domain containing protein	0.0203	0.3422	0.3441
Loa Loa (eye worm)	hypothetical protein	0.0203	0.3422	0.3441
Loa Loa (eye worm)	hypothetical protein	0.0203	0.3422	0.3441
Echinococcus granulosus	SH2 motif	0.0203	0.3422	0.3422
Loa Loa (eye worm)	hypothetical protein	0.0203	0.3422	0.3441
Schistosoma mansoni	nck2/grb4	0.0203	0.3422	0.3441
Brugia malayi	SH2 domain containing protein	0.0203	0.3422	0.3441
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.033	0.9943	1
Schistosoma mansoni	tyrosine kinase	0.033	0.9943	1
Echinococcus multilocularis		0.0203	0.3422	0.3441
Toxoplasma gondii	aurora kinase	0.0136	0	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0204	0.3479	0.3499
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0203	0.3422	0.3441
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0136	0	0.5
Echinococcus multilocularis	tensin	0.0203	0.3422	0.3441
Echinococcus granulosus	tyrosine protein kinase Fyn	0.033	0.9943	0.9943
Brugia malayi	hypothetical protein	0.0203	0.3422	0.3441
Brugia malayi	SH2 domain containing protein	0.0203	0.3422	0.3441
Schistosoma mansoni	hypothetical protein	0.0203	0.3422	0.3441
Echinococcus multilocularis	tyrosine kinase	0.033	0.9943	1
Brugia malayi	Sex muscle abnormal protein 5	0.0203	0.3422	0.3441
Loa Loa (eye worm)	hypothetical protein	0.0203	0.3422	0.3441
Echinococcus granulosus	SH2 domain containing protein 7	0.0203	0.3422	0.3422
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.033	0.9943	0.9943
Brugia malayi	SH2 domain containing protein	0.0203	0.3422	0.3441
Echinococcus multilocularis	N chimaerin	0.0203	0.3422	0.3441
Echinococcus granulosus	NCK adaptor protein	0.0203	0.3422	0.3422
Echinococcus multilocularis	tyrosine protein kinase Abl	0.033	0.9943	1
Echinococcus multilocularis	SHC transforming protein 3	0.0203	0.3422	0.3441
Echinococcus granulosus	tyrosine kinase	0.033	0.9943	0.9943
Loa Loa (eye worm)	TK/FER protein kinase	0.033	0.9943	1
Loa Loa (eye worm)	TK/FER protein kinase	0.033	0.9943	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0203	0.3422	0.3422
Brugia malayi	Protein kinase domain containing protein	0.033	0.9943	1
Loa Loa (eye worm)	hypothetical protein	0.033	0.9943	1
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0203	0.3422	0.3441
Echinococcus multilocularis	NCK adaptor protein	0.0203	0.3422	0.3441
Schistosoma mansoni	tyrosine kinase	0.033	0.9943	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.033	0.9943	1
Echinococcus granulosus	SHC transforming protein 3	0.0203	0.3422	0.3422
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.033	0.9943	1
Onchocerca volvulus		0.033	0.9943	1
Schistosoma mansoni	tensin-related	0.0203	0.3422	0.3441
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.033	0.9943	1
Brugia malayi	Protein kinase domain containing protein	0.033	0.9943	1
Loa Loa (eye worm)	hypothetical protein	0.0203	0.3422	0.3441
Entamoeba histolytica	SH2 domain containing protein	0.0203	0.3422	0.3441
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.033	0.9943	0.9943
Echinococcus granulosus	growth factor receptor bound protein 2	0.0203	0.3422	0.3422
Schistosoma mansoni	adapter molecule crk	0.0203	0.3422	0.3441
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0203	0.3422	0.3441
Echinococcus granulosus	tyrosine kinase	0.033	0.9943	0.9943
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.033	0.9943	0.9943
Loa Loa (eye worm)	TK/ABL protein kinase	0.033	0.9943	1
Schistosoma mansoni	tyrosine kinase	0.033	0.9943	1
Onchocerca volvulus		0.033	0.9943	1
Schistosoma mansoni	hypothetical protein	0.0203	0.3422	0.3441
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0203	0.3422	0.3441
Onchocerca volvulus		0.033	0.9943	1
Loa Loa (eye worm)	TK/FER protein kinase	0.033	0.9943	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.033	0.9943	0.9943
Loa Loa (eye worm)	hypothetical protein	0.0203	0.3422	0.3441
Loa Loa (eye worm)	TK/FER protein kinase	0.033	0.9943	1
Echinococcus multilocularis	tyrosine protein kinase shark	0.033	0.9943	1
Trichomonas vaginalis	AGC family protein kinase	0.0136	0	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0203	0.3422	0.3422
Schistosoma mansoni	tensin	0.0203	0.3422	0.3441
Echinococcus granulosus	tyrosine protein kinase Fyn	0.033	0.9943	0.9943
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.033	0.9943	1
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0203	0.3422	0.3441
Brugia malayi	Protein kinase domain containing protein	0.033	0.9943	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0203	0.3422	0.3441
Brugia malayi	Variant SH3 domain containing protein	0.0203	0.3422	0.3441
Echinococcus granulosus	tensin	0.0203	0.3422	0.3422
Echinococcus multilocularis	tyrosine protein kinase Blk	0.033	0.9943	1
Brugia malayi	Protein kinase domain containing protein	0.033	0.9943	1
Brugia malayi	SH2 domain containing protein	0.033	0.9943	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.033	0.9943	1
Onchocerca volvulus		0.033	0.9943	1
Schistosoma mansoni	tyrosine kinase	0.033	0.9943	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.033	0.9943	1
Loa Loa (eye worm)	hypothetical protein	0.0203	0.3422	0.3441
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0203	0.3422	0.3441
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0203	0.3422	0.3441
Echinococcus granulosus	c src tyrosine kinase	0.033	0.9943	0.9943
Schistosoma mansoni	tyrosine kinase	0.033	0.9943	1
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0203	0.3422	0.3441
Brugia malayi	Protein kinase domain containing protein	0.033	0.9943	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0203	0.3422	0.3422
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0203	0.3422	0.3422
Echinococcus granulosus	tyrosine protein kinase Blk	0.033	0.9943	0.9943
Brugia malayi	Variant SH3 domain containing protein	0.0203	0.3422	0.3441
Schistosoma mansoni	tensin	0.0203	0.3422	0.3441
Echinococcus granulosus	tyrosine protein kinase Src64B	0.033	0.9943	0.9943
Schistosoma mansoni	tensin-related	0.0203	0.3422	0.3441
Loa Loa (eye worm)	TK/FER protein kinase	0.033	0.9943	1
Echinococcus multilocularis	SH2 domain containing protein 7	0.0203	0.3422	0.3441
Schistosoma mansoni	growth factor receptor-bound protein	0.0203	0.3422	0.3441
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0203	0.3422	0.3441
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0203	0.3422	0.3441
Onchocerca volvulus		0.033	0.9943	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.033	0.9943	1
Schistosoma mansoni	tensin	0.0203	0.3422	0.3441
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.033	0.9943	1
Loa Loa (eye worm)	STAT protein	0.0203	0.3422	0.3441
Onchocerca volvulus		0.033	0.9943	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.033	0.9943	1
Loa Loa (eye worm)	TK protein kinase	0.033	0.9943	1
Brugia malayi	SH2 domain containing protein	0.0203	0.3422	0.3441
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0203	0.3422	0.3441
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0203	0.3422	0.3422
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.033	0.9943	1
Brugia malayi	Tensin	0.0203	0.3422	0.3441
Loa Loa (eye worm)	TK/FER protein kinase	0.033	0.9943	1
Trypanosoma brucei	aurora B kinase	0.0136	0	0.5
Schistosoma mansoni	tyrosine kinase	0.033	0.9943	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0203	0.3422	0.3441
Loa Loa (eye worm)	TK/FER protein kinase	0.033	0.9943	1
Loa Loa (eye worm)	hypothetical protein	0.0203	0.3422	0.3441
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0203	0.3422	0.3422
Brugia malayi	SRC-1	0.033	0.9943	1
Loa Loa (eye worm)	hypothetical protein	0.0203	0.3422	0.3441
Brugia malayi	Variant SH3 domain containing protein	0.0203	0.3422	0.3441
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0203	0.3422	0.3422
Echinococcus multilocularis	SH2 motif	0.0203	0.3422	0.3441
Loa Loa (eye worm)	SH2 domain-containing protein	0.0203	0.3422	0.3441
Loa Loa (eye worm)	SH2 domain-containing protein	0.0203	0.3422	0.3441
Giardia lamblia	Aurora kinase	0.0136	0	0.5
Echinococcus granulosus	tyrosine protein kinase Srms	0.033	0.9943	0.9943
Echinococcus multilocularis	signal transduction protein lnk realted	0.0203	0.3422	0.3441
Loa Loa (eye worm)	hypothetical protein	0.0203	0.3422	0.3441
Trichomonas vaginalis	AGC family protein kinase	0.0136	0	0.5
Echinococcus granulosus	tyrosine protein kinase ABL1	0.033	0.9943	0.9943
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0203	0.3422	0.3422
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.033	0.9943	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0203	0.3422	0.3441
Echinococcus granulosus	N chimaerin	0.0203	0.3422	0.3422
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0203	0.3422	0.3441
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.033	0.9943	1
Brugia malayi	Variant SH3 domain containing protein	0.0203	0.3422	0.3441
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0136	0	0.5
Echinococcus multilocularis	tensin	0.0203	0.3422	0.3441
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.033	0.9943	1
Schistosoma mansoni	suppressor of cytokine signaling	0.0203	0.3422	0.3441
Echinococcus granulosus	tyrosine protein kinase Fyn	0.033	0.9943	0.9943
Loa Loa (eye worm)	hypothetical protein	0.0203	0.3422	0.3441
Brugia malayi	protein-tyrosine kinase	0.033	0.9943	1
Schistosoma mansoni	GTPase activating protein	0.0203	0.3422	0.3441
Echinococcus granulosus	expressed conserved protein	0.0203	0.3422	0.3422
Loa Loa (eye worm)	SH2 domain-containing protein	0.0203	0.3422	0.3441
Echinococcus multilocularis	SH2 motif	0.0203	0.3422	0.3441
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.033	0.9943	1
Loa Loa (eye worm)	hypothetical protein	0.0203	0.3422	0.3441
Trichomonas vaginalis	AGC family protein kinase	0.0136	0	0.5
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0203	0.3422	0.3441
Echinococcus granulosus	SH2 motif	0.0203	0.3422	0.3422
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.033	0.9943	0.9943
Echinococcus multilocularis	SH2 motif	0.0203	0.3422	0.3441
Entamoeba histolytica	protein kinase, putative	0.0204	0.3479	0.3499
Brugia malayi	SH2 domain containing protein	0.0203	0.3422	0.3441
Echinococcus multilocularis	c src tyrosine kinase	0.033	0.9943	1
Loa Loa (eye worm)	TK/FER protein kinase	0.033	0.9943	1
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0203	0.3422	0.3441
Echinococcus granulosus	signal transduction protein lnk realted	0.0203	0.3422	0.3422
Schistosoma mansoni	growth factor receptor-bound protein	0.0203	0.3422	0.3441
Brugia malayi	SH2 domain containing protein	0.0203	0.3422	0.3441
Schistosoma mansoni	vav2	0.0203	0.3422	0.3441
Loa Loa (eye worm)	TK/FER protein kinase	0.033	0.9943	1
Trichomonas vaginalis	AGC family protein kinase	0.0136	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.033	0.9943	1
Schistosoma mansoni	signal transduction protein lnk-related	0.0203	0.3422	0.3441
Loa Loa (eye worm)	SRC-1	0.033	0.9943	1
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0203	0.3422	0.3441
Brugia malayi	hypothetical protein	0.033	0.9943	1
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.033	0.9943	1
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0203	0.3422	0.3441
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0203	0.3422	0.3441
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0203	0.3422	0.3441
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0203	0.3422	0.3441
Loa Loa (eye worm)	hypothetical protein	0.0203	0.3422	0.3441
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0203	0.3422	0.3441
Echinococcus granulosus	tyrosine protein kinase shark	0.033	0.9943	0.9943
Echinococcus granulosus	hypothetical protein	0.0203	0.3422	0.3422
Trypanosoma cruzi	aurora B kinase, putative	0.0136	0	0.5
Leishmania major	protein kinase, putative	0.0136	0	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1 nM	Inhibition of aurora-B (unknown origin)	ChEMBL.	23570792
IC50 (binding)	= 4 nM	Inhibition of aurora-A (unknown origin)	ChEMBL.	23570792
IC50 (functional)	= 719 nM	Antiproliferative activity against human MIAPaCa2 cells	ChEMBL.	23570792

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	23570792

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2380827

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1764789