Detailed information for compound 1765215

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 376.448 | Formula: C23H24N2O3
  • H donors: 0 H acceptors: 3 LogP: 3.88 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CC(=O)N(C(=O)N1CC(c1ccccc1)c1ccccc1)C1CCCC1
  • InChi: 1S/C23H24N2O3/c26-21-15-22(27)25(19-13-7-8-14-19)23(28)24(21)16-20(17-9-3-1-4-10-17)18-11-5-2-6-12-18/h1-6,9-12,19-20H,7-8,13-16H2
  • InChiKey: VRTMCLSXDVZSAW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1D subunit Starlite/ChEMBL References
Oryctolagus cuniculus Voltage-gated L-type calcium channel alpha-1C subunit Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04344 calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent N-type calcium channel subunit alpha-1B, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04853 calcium channel, voltage-dependent, L type, alpha 1F subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent calcium channel type d subunit Get druggable targets OG5_126791 All targets in OG5_126791
Toxoplasma gondii transporter, cation channel family protein Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04850 calcium channel, voltage-dependent, L type, alpha 1C subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Toxoplasma gondii hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Neospora caninum hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Muscle calcium channel subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type D subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma mansoni voltage-gated cation channel Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type A subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type A subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Probable voltage-dependent R-type calcium channel subunit alpha-1E, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type D subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum expressed protein Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent L type calcium channel subunit Get druggable targets OG5_126791 All targets in OG5_126791
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) voltage-dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma congolense Voltage-dependent calcium channel subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma brucei gambiense calcium channel protein, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma mansoni high voltage-activated calcium channel Cav2A Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum expressed protein Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent L type calcium channel subunit Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent calcium channel type d subunit Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04849 calcium channel, voltage-dependent, N type, alpha 1B subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma mansoni high voltage-activated calcium channel Cav1 Get druggable targets OG5_126791 All targets in OG5_126791
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Echinococcus granulosus tyrosine kinase 0.0395 1 1
Trypanosoma brucei Flagellum attachment zone protein 20 0.0155 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0395 1 1
Onchocerca volvulus 0.024 0.3534 0.3534
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Loa Loa (eye worm) hypothetical protein 0.024 0.3534 0.3534
Onchocerca volvulus 0.0395 1 1
Leishmania major protein kinase, putative 0.0155 0 0.5
Schistosoma mansoni GTPase activating protein 0.024 0.3534 0.3534
Loa Loa (eye worm) hypothetical protein 0.024 0.3534 0.3534
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Brugia malayi Variant SH3 domain containing protein 0.024 0.3534 0.3534
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Brugia malayi SH2 domain containing protein 0.0395 1 1
Schistosoma mansoni tyrosine kinase 0.0395 1 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.0395 1 1
Schistosoma mansoni hypothetical protein 0.024 0.3534 0.3534
Entamoeba histolytica SH2-protein kinase domain containing protein 0.024 0.3534 0.3534
Echinococcus granulosus tyrosine protein kinase shark 0.0395 1 1
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0395 1 1
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Loa Loa (eye worm) hypothetical protein 0.024 0.3534 0.3534
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0186 0.1279 0.1279
Loa Loa (eye worm) TK/FER protein kinase 0.0395 1 1
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0186 0.1279 0.1279
Schistosoma mansoni vav2 0.024 0.3534 0.3534
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Echinococcus granulosus SH2 domain containing adapter protein F 0.024 0.3534 0.3534
Echinococcus multilocularis tyrosine protein kinase Blk 0.0395 1 1
Echinococcus multilocularis tensin 0.024 0.3534 0.3534
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Brugia malayi Variant SH3 domain containing protein 0.024 0.3534 0.3534
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Giardia lamblia Kinase 0.0155 0 0.5
Toxoplasma gondii protein kinase 0.0155 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0395 1 1
Leishmania major hypothetical protein, conserved 0.0155 0 0.5
Brugia malayi Variant SH3 domain containing protein 0.024 0.3534 0.3534
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.024 0.3534 0.3534
Trichomonas vaginalis protein kinase atn1, putative 0.0155 0 0.5
Schistosoma mansoni growth factor receptor-bound protein 0.024 0.3534 0.3534
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Loa Loa (eye worm) STAT protein 0.024 0.3534 0.3534
Echinococcus multilocularis tyrosine protein kinase shark 0.0395 1 1
Echinococcus granulosus tyrosine protein kinase Blk 0.0395 1 1
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Onchocerca volvulus 0.024 0.3534 0.3534
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Echinococcus granulosus tyrosine protein kinase Src42A 0.024 0.3534 0.3534
Echinococcus multilocularis SH2 domain containing adapter protein F 0.024 0.3534 0.3534
Brugia malayi SH2 domain containing protein 0.024 0.3534 0.3534
Onchocerca volvulus 0.0395 1 1
Echinococcus granulosus SH2 motif 0.024 0.3534 0.3534
Onchocerca volvulus 0.024 0.3534 0.3534
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Toxoplasma gondii protein kinase domain-containing protein 0.0155 0 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0395 1 1
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0155 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0395 1 1
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Echinococcus multilocularis tyrosine kinase 0.0395 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0395 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0155 0 0.5
Brugia malayi Tensin 0.024 0.3534 0.3534
Schistosoma mansoni tensin 0.024 0.3534 0.3534
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Brugia malayi SH2 domain containing protein 0.024 0.3534 0.3534
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0395 1 1
Echinococcus granulosus c src tyrosine kinase 0.0395 1 1
Schistosoma mansoni shc transforming protein 0.024 0.3534 0.3534
Brugia malayi SRC-1 0.0395 1 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0395 1 1
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.024 0.3534 0.3534
Onchocerca volvulus 0.0395 1 1
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Schistosoma mansoni growth factor receptor-bound protein 0.024 0.3534 0.3534
Loa Loa (eye worm) hypothetical protein 0.024 0.3534 0.3534
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.024 0.3534 0.3534
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0395 1 1
Echinococcus granulosus SH2 domain containing protein 7 0.024 0.3534 0.3534
Leishmania major protein kinase, putative 0.0155 0 0.5
Brugia malayi Protein-tyrosine phosphatase containing protein 0.024 0.3534 0.3534
Plasmodium falciparum protein kinase, putative 0.0155 0 0.5
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0395 1 1
Schistosoma mansoni adapter molecule crk 0.024 0.3534 0.3534
Plasmodium falciparum protein kinase, putative 0.0155 0 0.5
Trichomonas vaginalis STE family protein kinase 0.0155 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Loa Loa (eye worm) hypothetical protein 0.024 0.3534 0.3534
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0186 0.1279 0.1279
Brugia malayi Variant SH3 domain containing protein 0.024 0.3534 0.3534
Schistosoma mansoni SH2A 0.024 0.3534 0.3534
Loa Loa (eye worm) TK/FER protein kinase 0.0395 1 1
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Echinococcus granulosus tyrosine protein kinase ABL1 0.0395 1 1
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Giardia lamblia Kinase, NEK 0.0155 0 0.5
Loa Loa (eye worm) TK protein kinase 0.0395 1 1
Loa Loa (eye worm) RhoGAP domain-containing protein 0.024 0.3534 0.3534
Echinococcus granulosus SH2 motif 0.024 0.3534 0.3534
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0155 0 0.5
Brugia malayi SH2 domain containing protein 0.024 0.3534 0.3534
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.024 0.3534 0.3534
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0186 0.1279 0.1279
Echinococcus multilocularis tensin 0.024 0.3534 0.3534
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0155 0 0.5
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0186 0.1279 0.1279
Echinococcus multilocularis c src tyrosine kinase 0.0395 1 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0155 0 0.5
Loa Loa (eye worm) variant SH3 domain-containing protein 0.024 0.3534 0.3534
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0155 0 0.5
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0395 1 1
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0155 0 0.5
Schistosoma mansoni nck2/grb4 0.024 0.3534 0.3534
Plasmodium vivax tyrosine kinase-like protein, putative 0.0155 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Brugia malayi Tyrosine-protein kinase abl-1 0.0395 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0155 0 0.5
Onchocerca volvulus 0.0395 1 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0395 1 1
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Schistosoma mansoni signal transduction protein lnk-related 0.024 0.3534 0.3534
Loa Loa (eye worm) hypothetical protein 0.024 0.3534 0.3534
Schistosoma mansoni suppressor of cytokine signaling 0.024 0.3534 0.3534
Trichomonas vaginalis conserved hypothetical protein 0.0155 0 0.5
Brugia malayi SH2 domain containing protein 0.024 0.3534 0.3534
Trichomonas vaginalis AGC family protein kinase 0.0155 0 0.5
Trypanosoma cruzi protein kinase, putative 0.0155 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Plasmodium vivax tyrosine kinase-like protein, putative 0.0155 0 0.5
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0155 0 0.5
Brugia malayi hypothetical protein 0.0395 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0395 1 1
Echinococcus multilocularis growth factor receptor bound protein 2 0.024 0.3534 0.3534
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0155 0 0.5
Echinococcus multilocularis NCK adaptor protein 0.024 0.3534 0.3534
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0395 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0395 1 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.024 0.3534 0.3534
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0395 1 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.0395 1 1
Giardia lamblia Kinase, NEK 0.0155 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0395 1 1
Brugia malayi tRNA modification GTPase TrmE family protein 0.024 0.3534 0.3534
Echinococcus multilocularis SH2 motif 0.024 0.3534 0.3534
Schistosoma mansoni tensin 0.024 0.3534 0.3534
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Loa Loa (eye worm) calcium channel 0.0186 0.1279 0.1279
Onchocerca volvulus 0.024 0.3534 0.3534
Giardia lamblia Protein 21.1 0.0155 0 0.5
Echinococcus multilocularis SHC transforming protein 3 0.024 0.3534 0.3534
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0395 1 1
Brugia malayi Protein kinase domain containing protein 0.0395 1 1
Schistosoma mansoni tensin-related 0.024 0.3534 0.3534
Loa Loa (eye worm) hypothetical protein 0.024 0.3534 0.3534
Echinococcus multilocularis SH2 motif 0.024 0.3534 0.3534
Echinococcus granulosus tyrosine protein kinase Fyn 0.0395 1 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0395 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0395 1 1
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0395 1 1
Loa Loa (eye worm) hypothetical protein 0.024 0.3534 0.3534
Schistosoma mansoni tensin-related 0.024 0.3534 0.3534
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.024 0.3534 0.3534
Brugia malayi hypothetical protein 0.024 0.3534 0.3534
Loa Loa (eye worm) hypothetical protein 0.024 0.3534 0.3534
Trichomonas vaginalis protein tyrosine kinase, putative 0.0155 0 0.5
Brugia malayi cytokine inducible SH2-containing protein 5 0.024 0.3534 0.3534
Echinococcus granulosus expressed conserved protein 0.024 0.3534 0.3534
Loa Loa (eye worm) hypothetical protein 0.024 0.3534 0.3534
Echinococcus multilocularis SH2 motif 0.024 0.3534 0.3534
Loa Loa (eye worm) SH2 domain-containing protein 0.024 0.3534 0.3534
Brugia malayi SH2 domain containing protein 0.024 0.3534 0.3534
Echinococcus granulosus tyrosine protein kinase Src42A 0.0395 1 1
Echinococcus granulosus suppressor of cytokine signaling 7 0.024 0.3534 0.3534
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Onchocerca volvulus 0.024 0.3534 0.3534
Plasmodium falciparum tyrosine kinase-like protein 0.0155 0 0.5
Plasmodium falciparum tyrosine kinase-like protein 0.0155 0 0.5
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0155 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Onchocerca volvulus 0.024 0.3534 0.3534
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Schistosoma mansoni tyrosine-protein kinase zap-70 0.024 0.3534 0.3534
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0186 0.1279 0.1279
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0155 0 0.5
Echinococcus granulosus tyrosine protein kinase Fyn 0.0395 1 1
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.024 0.3534 0.3534
Loa Loa (eye worm) sex muscle abnormal protein 5 0.024 0.3534 0.3534
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0395 1 1
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Echinococcus multilocularis tyrosine protein kinase Src42A 0.024 0.3534 0.3534
Echinococcus multilocularis suppressor of cytokine signaling 7 0.024 0.3534 0.3534
Loa Loa (eye worm) hypothetical protein 0.0395 1 1
Brugia malayi Protein kinase domain containing protein 0.0395 1 1
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Loa Loa (eye worm) variant SH3 domain-containing protein 0.024 0.3534 0.3534
Schistosoma mansoni tyrosine kinase 0.0395 1 1
Echinococcus granulosus hypothetical protein 0.024 0.3534 0.3534
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.024 0.3534 0.3534
Echinococcus granulosus tyrosine kinase 0.0395 1 1
Brugia malayi STAT protein, DNA binding domain containing protein 0.024 0.3534 0.3534
Onchocerca volvulus 0.0395 1 1
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0395 1 1
Brugia malayi Protein kinase domain containing protein 0.0395 1 1
Echinococcus granulosus tensin 0.024 0.3534 0.3534
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0186 0.1279 0.1279
Loa Loa (eye worm) TK/ABL protein kinase 0.0395 1 1
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.024 0.3534 0.3534
Brugia malayi SH2 domain containing protein 0.0395 1 1
Echinococcus granulosus NCK adaptor protein 0.024 0.3534 0.3534
Echinococcus granulosus growth factor receptor bound protein 2 0.024 0.3534 0.3534
Brugia malayi SH2 domain containing protein 0.024 0.3534 0.3534
Plasmodium vivax protein kinase, putative 0.0155 0 0.5
Echinococcus granulosus tyrosine protein kinase Src64B 0.0395 1 1
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0155 0 0.5
Echinococcus multilocularis suppressor of cytokine signaling 6 0.024 0.3534 0.3534
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Entamoeba histolytica protein kinase, putative 0.024 0.3534 0.3534
Echinococcus multilocularis SH2 domain containing protein 7 0.024 0.3534 0.3534
Schistosoma mansoni tyrosine kinase 0.0395 1 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.024 0.3534 0.3534
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Schistosoma mansoni tyrosine kinase 0.0395 1 1
Trypanosoma brucei Pseudokinase, putative 0.0155 0 0.5
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.024 0.3534 0.3534
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0155 0 0.5
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0186 0.1279 0.1279
Schistosoma mansoni hypothetical protein 0.024 0.3534 0.3534
Loa Loa (eye worm) SH2 domain-containing protein 0.024 0.3534 0.3534
Brugia malayi Sex muscle abnormal protein 5 0.024 0.3534 0.3534
Schistosoma mansoni voltage-gated cation channel 0.0186 0.1279 0.1279
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0186 0.1279 0.1279
Plasmodium falciparum protein kinase, putative 0.0155 0 0.5
Schistosoma mansoni tyrosine kinase 0.0395 1 1
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0186 0.1279 0.1279
Loa Loa (eye worm) TK/FER protein kinase 0.0395 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0155 0 0.5
Echinococcus multilocularis tyrosine protein kinase Srms 0.0395 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0395 1 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.024 0.3534 0.3534
Onchocerca volvulus 0.0395 1 1
Loa Loa (eye worm) hypothetical protein 0.024 0.3534 0.3534
Brugia malayi protein-tyrosine kinase 0.0395 1 1
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Loa Loa (eye worm) hypothetical protein 0.024 0.3534 0.3534
Loa Loa (eye worm) hypothetical protein 0.024 0.3534 0.3534
Echinococcus granulosus SHC transforming protein 3 0.024 0.3534 0.3534
Echinococcus multilocularis 0.024 0.3534 0.3534
Echinococcus granulosus voltage dependent calcium channel 0.0186 0.1279 0.1279
Echinococcus multilocularis signal transduction protein lnk realted 0.024 0.3534 0.3534
Schistosoma mansoni tyrosine kinase 0.0395 1 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.024 0.3534 0.3534
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.024 0.3534 0.3534
Trichomonas vaginalis TK family protein kinase 0.0155 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Brugia malayi SH2 domain containing protein 0.024 0.3534 0.3534
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Echinococcus granulosus tyrosine protein kinase Fyn 0.0395 1 1
Echinococcus granulosus signal transduction protein lnk realted 0.024 0.3534 0.3534
Entamoeba histolytica SH2 domain containing protein 0.024 0.3534 0.3534
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Echinococcus multilocularis voltage dependent calcium channel 0.0186 0.1279 0.1279
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Echinococcus granulosus suppressor of cytokine signaling 6 0.024 0.3534 0.3534
Loa Loa (eye worm) SRC-1 0.0395 1 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.024 0.3534 0.3534
Loa Loa (eye worm) SH2 domain-containing protein 0.024 0.3534 0.3534
Echinococcus multilocularis voltage dependent calcium channel 0.0186 0.1279 0.1279
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0155 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0155 0 0.5
Trypanosoma cruzi protein kinase, putative 0.0155 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.024 0.3534 0.3534
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0395 1 1
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Echinococcus multilocularis N chimaerin 0.024 0.3534 0.3534
Echinococcus granulosus tensin C1 domain containing phosphatase 0.024 0.3534 0.3534
Echinococcus multilocularis suppressor of cytokine signaling 7 0.024 0.3534 0.3534
Schistosoma mansoni tensin 0.024 0.3534 0.3534
Echinococcus granulosus tyrosine protein kinase Srms 0.0395 1 1
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Toxoplasma gondii STE kinase 0.0155 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0155 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0186 0.1279 0.1279
Brugia malayi Protein kinase domain containing protein 0.0395 1 1
Brugia malayi RhoGAP domain containing protein 0.024 0.3534 0.3534
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0395 1 1
Echinococcus granulosus N chimaerin 0.024 0.3534 0.3534
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0395 1 1
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Schistosoma mansoni suppressor of cytokine signaling 0.024 0.3534 0.3534
Trichomonas vaginalis TKL family protein kinase 0.0155 0 0.5
Trypanosoma brucei protein kinase, putative 0.0155 0 0.5
Loa Loa (eye worm) hypothetical protein 0.024 0.3534 0.3534
Loa Loa (eye worm) hypothetical protein 0.024 0.3534 0.3534

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5.2 uM Antagonist activity at rat CaV1.3alpha1D transfected in HEK293 cells by FLIPR assay ChEMBL. 23651412
IC50 (binding) = 8.1 uM Antagonist activity at rabbit CaV1.2alpha1C transfected in HEK293 cells by FLIPR assay ChEMBL. 23651412

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.