Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | STE/STE7/MEK7 protein kinase | 0.5058 | 1 | 1 |
Loa Loa (eye worm) | STE/STE7/MEK7 protein kinase | 0.5058 | 1 | 1 |
Onchocerca volvulus | Kinase homolog | 0.0183 | 0 | 0.5 |
Schistosoma mansoni | protein kinase | 0.5058 | 1 | 1 |
Echinococcus multilocularis | dual specificity mitogen activated protein | 0.5058 | 1 | 1 |
Echinococcus granulosus | dual specificity mitogen activated protein | 0.5058 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | Antibacterial activity against Escherichia coli ATCC 8099 assessed as growth inhibition at 1000 ug/mL after 24 hrs by disk diffusion method | ChEMBL. | 23489634 | |
MIC (functional) | > 500 ug ml-1 | Antifungal activity against Candida albicans ATCC 10231 assessed as growth inhibition after 24 hrs by microbroth dilution method | ChEMBL. | 23489634 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.