Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | monoglyceride lipase | Starlite/ChEMBL | References |
Rattus norvegicus | Anandamide amidohydrolase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.7 % |
Schistosoma japonicum | Fatty-acid amide hydrolase 1, putative | Anandamide amidohydrolase | 579 aa | 499 aa | 24.6 % |
Onchocerca volvulus | Anandamide amidohydrolase | 579 aa | 539 aa | 34.7 % | |
Plasmodium falciparum | esterase, putative | monoglyceride lipase | 303 aa | 254 aa | 19.7 % |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | monoglyceride lipase, putative | 0.0084 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0084 | 0 | 0.5 |
Echinococcus multilocularis | oligomeric golgi complex subunit 3 | 0.0639 | 0.2652 | 0.2513 |
Echinococcus granulosus | oligomeric golgi complex subunit 3 | 0.0639 | 0.2652 | 0.2513 |
Entamoeba histolytica | cyclin C, putative | 0.0648 | 0.2697 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2176 | 1 | 1 |
Loa Loa (eye worm) | cyclin C | 0.1287 | 0.5752 | 0.5672 |
Brugia malayi | Cyclin C | 0.1287 | 0.5752 | 0.5672 |
Loa Loa (eye worm) | CMGC/CDK/CDK8 protein kinase | 0.2176 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0084 | 0 | 0.5 |
Plasmodium vivax | PST-A protein | 0.0084 | 0 | 0.5 |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 0 | 0.5 |
Echinococcus granulosus | cyclin dependent kinase 19 | 0.2176 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0 | 0.5 |
Trichomonas vaginalis | valacyclovir hydrolase, putative | 0.0084 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible lysophospholipase | 0.0084 | 0 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 19 | 0.2176 | 1 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 0 | 0.5 |
Mycobacterium ulcerans | lysophospholipase | 0.0084 | 0 | 0.5 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0639 | 0.2652 | 0.2513 |
Plasmodium falciparum | esterase, putative | 0.0084 | 0 | 0.5 |
Loa Loa (eye worm) | gastrulation defective protein 1 | 0.2168 | 0.9963 | 0.9963 |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 0 | 0.5 |
Echinococcus granulosus | cyclin | 0.0639 | 0.2652 | 0.2513 |
Leishmania major | monoglyceride lipase, putative | 0.0084 | 0 | 0.5 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0084 | 0 | 0.5 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0084 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0084 | 0 | 0.5 |
Echinococcus multilocularis | cyclin | 0.0639 | 0.2652 | 0.2513 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0 | 0.5 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0639 | 0.2652 | 0.2513 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.0084 | 0 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0 | 0.5 |
Schistosoma mansoni | g1/s-specific cyclin C | 0.1287 | 0.5752 | 0.5672 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.005 uM | Inhibition of FAAH in Sprague-Dawley rat brain microsomes assessed as N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide conversion to 4-pyren-1-ylbutanoic acid preincubated for 10 mins measured after 45 mins by HPLC analysis | ChEMBL. | 23455058 |
IC50 (binding) | = 0.015 uM | Inhibition of human recombinant MAGL-mediated 1,3-dihydroxypropan-1-yl 4-pyren-1-ylbutanoate conversion to 4-pyren-1-ylbutanoic acid preincubated for 15 mins measured after 45 mins by HPLC analysis | ChEMBL. | 23455058 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.