Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Oryctolagus cuniculus | Voltage-gated L-type calcium channel alpha-1C subunit | Starlite/ChEMBL | References |
Rattus norvegicus | Voltage-gated L-type calcium channel alpha-1D subunit | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0186 | 0.4639 | 0.458 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.0369 | 1 | 1 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0065 | 0.1089 | 0.0991 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.0369 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0369 | 1 | 0.5 |
Brugia malayi | Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog | 0.0186 | 0.4639 | 0.458 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.1089 | 0.0991 |
Trypanosoma brucei | Casein kinase II | 0.0369 | 1 | 1 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0186 | 0.4639 | 0.458 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0369 | 1 | 0.5 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0186 | 0.4639 | 0.458 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.4639 | 0.458 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0369 | 1 | 0.5 |
Schistosoma mansoni | high voltage-activated calcium channel Cav2A | 0.0186 | 0.4639 | 0.458 |
Schistosoma mansoni | voltage-gated cation channel | 0.0186 | 0.4639 | 0.458 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0369 | 1 | 0.5 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.0369 | 1 | 1 |
Plasmodium vivax | unspecified product | 0.0369 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0369 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0369 | 1 | 0.5 |
Trypanosoma cruzi | casein kinase II, putative | 0.0369 | 1 | 1 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0065 | 0.1089 | 0.025 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0186 | 0.4639 | 0.458 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.0369 | 1 | 1 |
Entamoeba histolytica | casein kinase, putative | 0.0369 | 1 | 0.5 |
Leishmania major | casein kinase II, putative | 0.0369 | 1 | 0.5 |
Loa Loa (eye worm) | CAMK/CAMKL/PASK protein kinase | 0.0238 | 0.6147 | 0.6105 |
Schistosoma mansoni | protein kinase | 0.0369 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.086 | 0.076 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0186 | 0.4639 | 0.458 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.0369 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0369 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.086 | 0.076 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.0186 | 0.4639 | 0.458 |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.0186 | 0.4639 | 0.458 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0369 | 1 | 0.5 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.0186 | 0.4639 | 0.458 |
Loa Loa (eye worm) | calcium channel | 0.0186 | 0.4639 | 0.458 |
Loa Loa (eye worm) | voltage-dependent calcium channel | 0.0065 | 0.1089 | 0.0991 |
Trypanosoma brucei | Voltage-dependent calcium channel subunit, putative | 0.0065 | 0.1089 | 0.1089 |
Onchocerca volvulus | 0.0238 | 0.6147 | 0.5 | |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0186 | 0.4639 | 0.458 |
Giardia lamblia | Kinase, CMGC CK2 | 0.0369 | 1 | 0.5 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0186 | 0.4639 | 0.458 |
Schistosoma mansoni | high voltage-activated calcium channel Cav1 | 0.0186 | 0.4639 | 0.458 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.0369 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.17 uM | Antagonist activity at rabbit voltage-dependent L-type calcium channel Cav1.2alpha-1C expressed in HEK293 cells by FLIPR assay | ChEMBL. | 23688558 |
IC50 (binding) | = 0.88 uM | Antagonist activity at rat voltage-dependent L-type calcium channel Cav1.3alpha-1D expressed in HEK293 cells by FLIPR assay | ChEMBL. | 23688558 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.