Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | neuropeptide FF receptor 2 | 0.0103 | 0.0013 | 0.0013 |
Schistosoma mansoni | lar interacting protein (lip)-related protein | 0.0119 | 0.0037 | 0.0024 |
Onchocerca volvulus | 0.0119 | 0.0037 | 1 | |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0468 | 0.0561 | 0.0548 |
Brugia malayi | G-protein coupled receptor | 0.0103 | 0.0013 | 0.0013 |
Echinococcus granulosus | stromal interaction molecule 1 | 0.1497 | 0.2103 | 0.2093 |
Brugia malayi | hypothetical protein | 0.0103 | 0.0013 | 0.0013 |
Echinococcus multilocularis | g protein coupled receptor | 0.0103 | 0.0013 | 0.0013 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.0037 | 0.0024 |
Echinococcus multilocularis | neuropeptide receptor | 0.0103 | 0.0013 | 0.0013 |
Brugia malayi | Serotonin receptor | 0.0103 | 0.0013 | 0.0013 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.014 | 0.0069 | 0.0069 |
Schistosoma mansoni | tyrosine kinase | 0.0227 | 0.02 | 0.0187 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0103 | 0.0013 | 0.0013 |
Echinococcus granulosus | liprin beta 1 | 0.0119 | 0.0037 | 0.0024 |
Brugia malayi | AKH receptor | 0.0103 | 0.0013 | 0.0013 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0103 | 0.0013 | 0.0013 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.0037 | 0.0024 |
Brugia malayi | neuropeptide F receptor | 0.0103 | 0.0013 | 0.0013 |
Echinococcus multilocularis | fmrfamide receptor | 0.0103 | 0.0013 | 0.0013 |
Schistosoma mansoni | hypothetical protein | 0.0119 | 0.0037 | 0.0024 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0103 | 0.0013 | 0.0013 |
Brugia malayi | larval opioid receptor | 0.0103 | 0.0013 | 0.0013 |
Brugia malayi | Neurabin protein 1 | 0.0119 | 0.0037 | 0.0037 |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.0103 | 0.0013 | 0.0013 |
Brugia malayi | Melatonin receptor type 1A | 0.0103 | 0.0013 | 0.0013 |
Brugia malayi | hypothetical protein | 0.0103 | 0.0013 | 0.0013 |
Brugia malayi | GnHR receptor homolog | 0.0103 | 0.0013 | 0.0013 |
Toxoplasma gondii | Tyrosine kinase-like (TKL) protein | 0.0119 | 0.0037 | 0.5 |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | 0.0103 | 0.0013 | 0.0013 |
Brugia malayi | hypothetical protein | 0.0103 | 0.0013 | 0.0013 |
Echinococcus multilocularis | tachykinin peptides receptor 99D | 0.0103 | 0.0013 | 0.0013 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0231 | 0.0205 | 0.0205 |
Brugia malayi | hypothetical protein | 0.0119 | 0.0037 | 0.0037 |
Echinococcus multilocularis | calcium release activated calcium channel | 0.6764 | 1 | 1 |
Brugia malayi | neuropeptide F receptor | 0.0103 | 0.0013 | 0.0013 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0119 | 0.0037 | 0.5 |
Echinococcus multilocularis | g protein coupled receptor | 0.0103 | 0.0013 | 0.0013 |
Loa Loa (eye worm) | hypothetical protein | 0.6764 | 1 | 1 |
Schistosoma mansoni | amine GPCR | 0.2772 | 0.4016 | 0.4008 |
Echinococcus granulosus | tankyrase | 0.0119 | 0.0037 | 0.0024 |
Brugia malayi | Serotonin receptor | 0.0103 | 0.0013 | 0.0013 |
Echinococcus multilocularis | G-protein coupled receptor, putative | 0.0103 | 0.0013 | 0.0013 |
Echinococcus multilocularis | neuropeptides capa receptor | 0.0103 | 0.0013 | 0.0013 |
Loa Loa (eye worm) | hypothetical protein | 0.1503 | 0.2112 | 0.2101 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0103 | 0.0013 | 0.0013 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0103 | 0.0013 | 0.0013 |
Echinococcus multilocularis | sex peptide receptor | 0.0103 | 0.0013 | 0.0013 |
Echinococcus multilocularis | neuropeptide Y receptor | 0.0103 | 0.0013 | 0.0013 |
Brugia malayi | hypothetical protein | 0.0103 | 0.0013 | 0.0013 |
Echinococcus multilocularis | g-protein coupled receptor | 0.0103 | 0.0013 | 0.0013 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0103 | 0.0013 | 0.0013 |
Echinococcus multilocularis | 7TM GPCR, rhodopsin | 0.0103 | 0.0013 | 0.0013 |
Echinococcus multilocularis | alpha 1A adrenergic receptor | 0.0103 | 0.0013 | 0.0013 |
Brugia malayi | sulfakinin receptor protein | 0.0103 | 0.0013 | 0.0013 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0103 | 0.0013 | 0.0013 |
Schistosoma mansoni | hypothetical protein | 0.0811 | 0.1076 | 0.1064 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0231 | 0.0205 | 0.0192 |
Echinococcus multilocularis | fmrfamide receptor | 0.0103 | 0.0013 | 0.0013 |
Echinococcus granulosus | liprin alpha 2 | 0.0119 | 0.0037 | 0.0024 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0103 | 0.0013 | 0.0013 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.1503 | 0.2112 | 0.2101 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0231 | 0.0205 | 0.0192 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0103 | 0.0013 | 0.0013 |
Onchocerca volvulus | 0.0119 | 0.0037 | 1 | |
Echinococcus multilocularis | tankyrase | 0.0119 | 0.0037 | 0.0037 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0103 | 0.0013 | 0.0013 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.1503 | 0.2112 | 0.2101 |
Brugia malayi | Liprin-alpha 2 | 0.0119 | 0.0037 | 0.0037 |
Schistosoma mansoni | tankyrase | 0.0119 | 0.0037 | 0.0024 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0119 | 0.0037 | 0.5 |
Brugia malayi | hypothetical protein | 0.0103 | 0.0013 | 0.0013 |
Echinococcus multilocularis | serotonin receptor | 0.1503 | 0.2112 | 0.2112 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0119 | 0.0037 | 0.5 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0103 | 0.0013 | 0.0013 |
Echinococcus multilocularis | stromal interaction molecule 1 | 0.1497 | 0.2103 | 0.2103 |
Schistosoma mansoni | Protein orai-1 | 0.6764 | 1 | 1 |
Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | 0.0103 | 0.0013 | 0.0013 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0103 | 0.0013 | 0.0013 |
Brugia malayi | G protein-coupled receptor | 0.0103 | 0.0013 | 0.0013 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0103 | 0.0013 | 0.0013 |
Schistosoma mansoni | hypothetical protein | 0.0119 | 0.0037 | 0.0024 |
Echinococcus multilocularis | dro:myosuppressin receptor | 0.0103 | 0.0013 | 0.0013 |
Brugia malayi | sterile alpha and TIR motif containing protein 1 isoform a | 0.0119 | 0.0037 | 0.0037 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0103 | 0.0013 | 0.0013 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0103 | 0.0013 | 0.0013 |
Brugia malayi | hypothetical protein | 0.1497 | 0.2103 | 0.2103 |
Plasmodium vivax | tyrosine kinase-like protein, putative | 0.012 | 0.0038 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0103 | 0.0013 | 0.0013 |
Echinococcus multilocularis | G protein coupled 5 hydroxytryptamine receptor | 0.0103 | 0.0013 | 0.0013 |
Brugia malayi | Dopamine receptor protein 1 | 0.0103 | 0.0013 | 0.0013 |
Brugia malayi | hypothetical protein | 0.0103 | 0.0013 | 0.0013 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0103 | 0.0013 | 0.0013 |
Trichomonas vaginalis | c2h2 zinc finger protein, putative | 0.0119 | 0.0037 | 0.5 |
Echinococcus multilocularis | liprin alpha 2 | 0.0119 | 0.0037 | 0.0037 |
Brugia malayi | ORL1-like opioid receptor | 0.0103 | 0.0013 | 0.0013 |
Schistosoma mansoni | sarm1 | 0.0119 | 0.0037 | 0.0024 |
Brugia malayi | RE15519p | 0.0103 | 0.0013 | 0.0013 |
Echinococcus multilocularis | orexin receptor type 2 | 0.0103 | 0.0013 | 0.0013 |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.0103 | 0.0013 | 0.0013 |
Echinococcus granulosus | SAM domain containing protein | 0.0119 | 0.0037 | 0.0024 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.0037 | 0.0024 |
Loa Loa (eye worm) | hypothetical protein | 0.1497 | 0.2103 | 0.2093 |
Echinococcus multilocularis | sterile alpha and tir motif containing protein | 0.0119 | 0.0037 | 0.0037 |
Loa Loa (eye worm) | hypothetical protein | 0.1503 | 0.2112 | 0.2101 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.0037 | 0.0024 |
Brugia malayi | Dopamine receptor | 0.0103 | 0.0013 | 0.0013 |
Brugia malayi | hypothetical protein | 0.0103 | 0.0013 | 0.0013 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0103 | 0.0013 | 0.0013 |
Echinococcus multilocularis | g protein coupled receptor | 0.0103 | 0.0013 | 0.0013 |
Brugia malayi | Dopamine receptor protein 2 | 0.0103 | 0.0013 | 0.0013 |
Brugia malayi | hypothetical protein | 0.0103 | 0.0013 | 0.0013 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0119 | 0.0037 | 0.5 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0103 | 0.0013 | 0.0013 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.0468 | 0.0561 | 0.0561 |
Brugia malayi | G-protein coupled receptor | 0.0103 | 0.0013 | 0.0013 |
Schistosoma mansoni | hypothetical protein | 0.0685 | 0.0887 | 0.0874 |
Echinococcus multilocularis | serotonin receptor | 0.1503 | 0.2112 | 0.2112 |
Echinococcus granulosus | calcium release activated calcium channel | 0.6764 | 1 | 1 |
Loa Loa (eye worm) | toll and interleukin 1 receptor domain-containing protein isoform f | 0.0119 | 0.0037 | 0.0024 |
Brugia malayi | hypothetical protein | 0.0103 | 0.0013 | 0.0013 |
Echinococcus multilocularis | somatostatin receptor | 0.0103 | 0.0013 | 0.0013 |
Echinococcus granulosus | sterile alpha and tir motif containing protein | 0.0119 | 0.0037 | 0.0024 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0103 | 0.0013 | 0.0013 |
Echinococcus multilocularis | neuropeptides capa receptor | 0.0103 | 0.0013 | 0.0013 |
Echinococcus granulosus | Sterile alpha motif SAM | 0.0119 | 0.0037 | 0.0024 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0468 | 0.0561 | 0.0548 |
Plasmodium falciparum | tyrosine kinase-like protein | 0.012 | 0.0038 | 0.5 |
Brugia malayi | coiled-coil like protein 1 | 0.0119 | 0.0037 | 0.0037 |
Brugia malayi | Tnks protein | 0.0119 | 0.0037 | 0.0037 |
Echinococcus multilocularis | neuropeptide Y receptor | 0.0103 | 0.0013 | 0.0013 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0103 | 0.0013 | 0.0013 |
Echinococcus multilocularis | pyroglutamylated rfamide peptide receptor | 0.0103 | 0.0013 | 0.0013 |
Brugia malayi | hypothetical protein | 0.0103 | 0.0013 | 0.0013 |
Echinococcus multilocularis | allatostatin A receptor | 0.0103 | 0.0013 | 0.0013 |
Schistosoma mansoni | hypothetical protein | 0.0119 | 0.0037 | 0.0024 |
Brugia malayi | putative neuropeptide receptor | 0.0103 | 0.0013 | 0.0013 |
Schistosoma mansoni | lip-related protein (liprin) alpha | 0.0119 | 0.0037 | 0.0024 |
Echinococcus multilocularis | neuropeptide receptor | 0.0103 | 0.0013 | 0.0013 |
Echinococcus multilocularis | liprin beta 1 | 0.0119 | 0.0037 | 0.0037 |
Schistosoma mansoni | Protein orai-1 | 0.6764 | 1 | 1 |
Plasmodium falciparum | protein kinase, putative | 0.012 | 0.0038 | 0.5 |
Echinococcus multilocularis | SAM domain containing protein | 0.0119 | 0.0037 | 0.0037 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0103 | 0.0013 | 0.0013 |
Brugia malayi | follicle stimulating hormone receptor | 0.0103 | 0.0013 | 0.0013 |
Echinococcus multilocularis | peptide (allatostatin:somatostatin) | 0.0103 | 0.0013 | 0.0013 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.889 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.829 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.761 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.737 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.704 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.693 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.643 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.637 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.547 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.