Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glycogen synthase kinase 3-related (gsk3) (cmgc group III) | 0.0047 | 0.0077 | 1 |
Toxoplasma gondii | macrophage migration inhibitory factor, putative | 0.2171 | 1 | 1 |
Onchocerca volvulus | 0.0047 | 0.0077 | 0.5 | |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.2171 | 1 | 1 |
Echinococcus multilocularis | glycogen synthase kinase 3 beta | 0.0047 | 0.0077 | 1 |
Plasmodium vivax | macrophage migration inhibitory factor, putative | 0.2171 | 1 | 1 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0926 | 0.4184 | 0.4184 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.0047 | 0.0077 | 0.5 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.2171 | 1 | 1 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0926 | 0.4184 | 0.4184 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0033 | 0.0013 | 0.0013 |
Echinococcus granulosus | glycogen synthase kinase 3 beta | 0.0047 | 0.0077 | 1 |
Echinococcus multilocularis | protein kinase shaggy | 0.0047 | 0.0077 | 1 |
Echinococcus granulosus | protein kinase shaggy | 0.0047 | 0.0077 | 1 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0047 | 0.0077 | 0.0077 |
Plasmodium falciparum | macrophage migration inhibitory factor | 0.2171 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0047 | 0.0077 | 0.5 |
Brugia malayi | intracellular kinase | 0.0047 | 0.0077 | 0.0077 |
Giardia lamblia | Macrophage migration inhibitory factor | 0.2171 | 1 | 1 |
Trichomonas vaginalis | macrophage migration inhibitory factor, mif, putative | 0.2171 | 1 | 1 |
Entamoeba histolytica | macrophage migration inhibitory factor-like protein | 0.2171 | 1 | 1 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0047 | 0.0077 | 0.0077 |
Echinococcus granulosus | twitchin | 0.0031 | 0.0002 | 0.0272 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0033 | 0.0013 | 0.0013 |
Trichomonas vaginalis | conserved hypothetical protein | 0.2171 | 1 | 1 |
Loa Loa (eye worm) | macrophage migration inhibitory factor | 0.2171 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.