Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | STE/STE7/MEK7 protein kinase | 0.4175 | 1 | 1 |
Schistosoma mansoni | protein kinase | 0.4175 | 1 | 1 |
Onchocerca volvulus | Kinase homolog | 0.0318 | 0 | 0.5 |
Loa Loa (eye worm) | STE/STE7/MEK7 protein kinase | 0.4175 | 1 | 1 |
Echinococcus multilocularis | dual specificity mitogen activated protein | 0.4175 | 1 | 1 |
Echinococcus granulosus | dual specificity mitogen activated protein | 0.4175 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 25 uM | Cytotoxicity against human SNU638 cells by MTT assay | ChEMBL. | 23608763 |
IC50 (binding) | = 54.29 uM | Inhibition of cathepsin B (unknown origin) using RR-AMC as substrate after 30 mins by fluorescence assay | ChEMBL. | 23608763 |
IC50 (binding) | = 56.51 uM | Inhibition of cathepsin L (unknown origin) using Z-FR-AMC as substrate after 30 mins by fluorescence assay | ChEMBL. | 23608763 |
Inhibition (binding) | = 0 % | Inhibition of human topoisomerase 2 at 100 uM relative to control | ChEMBL. | 23608763 |
Inhibition (binding) | = 73.1 % | Inhibition of human topoisomerase 1 at 20 uM relative to control | ChEMBL. | 23608763 |
Inhibition (binding) | = 90.6 % | Inhibition of human topoisomerase 1 at 100 uM relative to control | ChEMBL. | 23608763 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.