Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sodium channel, voltage-gated, type V, alpha subunit | Starlite/ChEMBL | References |
Homo sapiens | sodium channel, voltage-gated, type II, alpha subunit | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | histone deacetylase 7 | 0.4261 | 0.9381 | 0.9381 |
Brugia malayi | Histone deacetylase family protein | 0.4261 | 0.9381 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.3768 | 0.8224 | 0.8767 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.4261 | 0.9381 | 0.9381 |
Echinococcus granulosus | histone deacetylase 6 | 0.4261 | 0.9381 | 0.9381 |
Plasmodium vivax | histone deacetylase, putative | 0.1824 | 0.3661 | 0.3903 |
Brugia malayi | Histone deacetylase family protein | 0.4261 | 0.9381 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2701 | 0.572 | 0.6097 |
Plasmodium falciparum | histone deacetylase 1 | 0.3768 | 0.8224 | 0.8767 |
Plasmodium vivax | histone deacetylase, putative | 0.4261 | 0.9381 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.4525 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC4 | 0.1824 | 0.3661 | 0.3903 |
Echinococcus multilocularis | histone deacetylase 3 | 0.3768 | 0.8224 | 0.8224 |
Loa Loa (eye worm) | histone deacetylase | 0.4261 | 0.9381 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.3768 | 0.8224 | 1 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.4261 | 0.9381 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.3768 | 0.8224 | 1 |
Plasmodium vivax | histone deacetylase 1, putative | 0.3768 | 0.8224 | 0.8767 |
Trypanosoma cruzi | histone deacetylase, putative | 0.1824 | 0.3661 | 0.3903 |
Trichomonas vaginalis | histone deacetylase, putative | 0.3768 | 0.8224 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2438 | 0.5101 | 0.5438 |
Trypanosoma brucei | histone deacetylase, putative | 0.4261 | 0.9381 | 1 |
Echinococcus granulosus | histone deacetylase 3 | 0.3768 | 0.8224 | 0.8224 |
Trichomonas vaginalis | histone deacetylase, putative | 0.3768 | 0.8224 | 1 |
Leishmania major | histone deacetylase, putative | 0.4261 | 0.9381 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.4261 | 0.9381 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.4261 | 0.9381 | 0.9381 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.3768 | 0.8224 | 0.8767 |
Trichomonas vaginalis | histone deacetylase, putative | 0.3768 | 0.8224 | 1 |
Brugia malayi | histone deacetylase 11 | 0.1824 | 0.3661 | 0.3903 |
Plasmodium falciparum | histone deacetylase 2 | 0.4261 | 0.9381 | 1 |
Trypanosoma brucei | histone deacetylase 1 | 0.3768 | 0.8224 | 0.8767 |
Schistosoma mansoni | histone deacetylase hda2 | 0.1824 | 0.3661 | 0.3661 |
Brugia malayi | Histone deacetylase 1 | 0.3768 | 0.8224 | 0.8767 |
Entamoeba histolytica | histone deacetylase, putative | 0.3768 | 0.8224 | 1 |
Leishmania major | histone deacetylase, putative | 0.3768 | 0.8224 | 0.8767 |
Trypanosoma brucei | histone deacetylase 4 | 0.4261 | 0.9381 | 1 |
Plasmodium vivax | histone deacetylase 2, putative | 0.4261 | 0.9381 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.3768 | 0.8224 | 0.8767 |
Trypanosoma brucei | histone deacetylase 3 | 0.4261 | 0.9381 | 1 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.3768 | 0.8224 | 0.8767 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.3768 | 0.8224 | 1 |
Giardia lamblia | Histone deacetylase | 0.3768 | 0.8224 | 1 |
Echinococcus multilocularis | histone deacetylase 8 | 0.1824 | 0.3661 | 0.3661 |
Trypanosoma brucei | histone deacetylase 2 | 0.1824 | 0.3661 | 0.3903 |
Echinococcus granulosus | histone deacetylase 6 | 0.4261 | 0.9381 | 0.9381 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.4261 | 0.9381 | 1 |
Leishmania major | histone deacetylase, putative | 0.4261 | 0.9381 | 1 |
Echinococcus multilocularis | histone deacetylase | 0.4261 | 0.9381 | 0.9381 |
Echinococcus multilocularis | histone deacetylase 6 | 0.4261 | 0.9381 | 0.9381 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.3768 | 0.8224 | 0.8767 |
Trichomonas vaginalis | histone deacetylase, putative | 0.3768 | 0.8224 | 1 |
Leishmania major | histone deacetylase, putative | 0.3768 | 0.8224 | 0.8767 |
Echinococcus granulosus | histone deacetylase 8 | 0.1824 | 0.3661 | 0.3661 |
Echinococcus multilocularis | histone deacetylase 6 | 0.4525 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.3768 | 0.8224 | 1 |
Schistosoma mansoni | histone deacetylase | 0.3768 | 0.8224 | 0.8224 |
Echinococcus granulosus | histone deacetylase 1 | 0.3768 | 0.8224 | 0.8224 |
Trypanosoma cruzi | histone deacetylase, putative | 0.4261 | 0.9381 | 1 |
Plasmodium falciparum | histone deacetylase, putative | 0.4261 | 0.9381 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.4261 | 0.9381 | 0.9381 |
Trypanosoma cruzi | histone deacetylase, putative | 0.1824 | 0.3661 | 0.3903 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.3768 | 0.8224 | 0.8767 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.1824 | 0.3661 | 0.3661 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.3768 | 0.8224 | 0.8767 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.1824 | 0.3661 | 0.3903 |
Loa Loa (eye worm) | hypothetical protein | 0.1824 | 0.3661 | 0.3903 |
Loa Loa (eye worm) | hypothetical protein | 0.3768 | 0.8224 | 0.8767 |
Trichomonas vaginalis | histone deacetylase, putative | 0.3768 | 0.8224 | 1 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.3768 | 0.8224 | 0.8767 |
Schistosoma mansoni | histone deacetylase | 0.3768 | 0.8224 | 0.8224 |
Echinococcus granulosus | histone deacetylase | 0.4261 | 0.9381 | 0.9381 |
Echinococcus granulosus | histone deacetylase 7 | 0.4261 | 0.9381 | 0.9381 |
Trypanosoma cruzi | histone deacetylase, putative | 0.4261 | 0.9381 | 1 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.1824 | 0.3661 | 1 |
Toxoplasma gondii | histone deacetylase HDAC5 | 0.1824 | 0.3661 | 0.3903 |
Echinococcus multilocularis | histone deacetylase 1 | 0.3768 | 0.8224 | 0.8224 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.6 uM | Inhibition of sodium channel blockade in CHO cells expressing human cardiac (hHI) sodium channel | ChEMBL. | 11720863 |
IC50 (binding) | = 3.6 uM | Inhibition of sodium channel blockade in CHO cells expressing human cardiac (hHI) sodium channel | ChEMBL. | 11720863 |
IC50 (binding) | = 4.3 uM | Inhibition of sodium channel blockade in CHO cells expressing neuronal mammalian type IIA (CNaIIA) sodium channel | ChEMBL. | 11720863 |
IC50 (binding) | = 4.3 uM | Inhibition of sodium channel blockade in CHO cells expressing neuronal mammalian type IIA (CNaIIA) sodium channel | ChEMBL. | 11720863 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.